Chunyu Liu
Profiles

Chunyu Liu, PhD

Research Associate Professor, Biostatistics - Boston University School of Public Health

Biography

Chunyu Liu was trained as a statistical geneticist and has just moved from the Framingham Heart Study (FHS), NHLBI, to Boston University, assuming a position of a research associate professor. She has participated in numerous projects evaluating risk factors for cardiovascular disease (CVD). These collaborations have yielded >60 peer-reviewed manuscripts on diverse topics related to CVD, including deciphering genes related to blood pressure/hypertension, heart disease and identification of epigenetic factors for blood pressure, lipids, and body mass index. In addition, for eight years, Chunyu has taught statistical methods in epidemiology at Boston University School of Public Health.
Her research spans several areas. After she joined the Population Sciences Branch and FHS, she focused on mitochondrial DNA (mtDNA) genetics and CVD. During her tenure at the FHS, she was mentored by Dr. Daniel Levy, who encouraged Chunyu to develop the expertise in mtDNA genetics. Due to her expertise in analyzing mtDNA variants, she was the lead statistician of the mtDNA working group of the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE), through which a manuscript has recently submitted to Nature Genetics. Mitochondrial genetics is complex because a single human cell contains many mtDNA copies bearing age-related somatic mutations mixed with inherited mtDNA alleles, a phenomenon called heteroplasmy. Heteroplasmic mutations can only be optimally detected by deep sequencing. Studying mtDNA copy number alone with a spectrum of mtDNA mutations in relation to age-related CMD traits in large samples has now become possible thanks to whole genome sequencing (WGS) through NHLBI’s TOPMed project. At present, Chunyu has been leading the effort to develop methods to analyze mtDNA sequence variations through the Trans-Omics for Precision Medicine (TOPMed) Mitochondrial DNA working group, the world’s largest study of mitochondrial genetics. Another of Chunyu's research areas has been focused on epigenetics and CVD. She was the lead statistician of the CHARGE DNA methylation alcohol working group during 2014-2017. In addition, she has been the lead statistician to conduct epigenomewide DNA association studies with many CVD risk factors in FHS, which has yielded multiple publications in higher tier journals.

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University

Education

  • Boston University, PhD Field of Study: Biostatistics
  • University of Maine, PhD Field of Study: Biochemistry
  • Boston University, MA Field of Study: Biostatistics

Classes Taught

  • SPHBS800
  • SPHBS852

Publications

  • Published on 9/4/2021

    Sun X, Ho JE, Gao H, Evangelou E, Yao C, Huan T, Hwang SJ, Courchesne P, Larson MG, Levy D, Ma J, Liu C. Associations of Alcohol Consumption with Cardiovascular Disease-Related Proteomic Biomarkers: The Framingham Heart Study. J Nutr. 2021 Sep 04; 151(9):2574-2582. PMID: 34159370.

    Read At: PubMed
  • Published on 8/20/2021

    Wang P, Castellani CA, Yao J, Huan T, Bielak LF, Zhao W, Haessler J, Roby J, Sun X, Guo X, Longchamps RJ, Manson JE, Grove ML, Bressler J, Taylor KD, Lappalainen T, Kasela S, Van Den Berg DJ, Hou L, Reiner A, Liu Y, Boerwinkle E, Smith JA, Peyser PA, Fornage M, Rich SS, Rotter JI, Kooperberg C, Arking DE, Levy D, Liu C. Epigenome-wide association study of mitochondrial genome copy number. Hum Mol Genet. 2021 Aug 20. PMID: 34415308.

    Read At: PubMed
  • Published on 7/21/2021

    Liu C, Fetterman JL, Qian Y, Sun X, Blackwell TW, Pitsillides A, Cade BE, Wang H, Raffield LM, Lange LA, Anugu P, Abecasis G, Adrienne Cupples L, Redline S, Correa A, Vasan RS, Wilson JG, Ding J, Levy D. Presence and transmission of mitochondrial heteroplasmic mutations in human populations of European and African ancestry. Mitochondrion. 2021 Sep; 60:33-42. PMID: 34303007.

    Read At: PubMed
  • Published on 6/24/2021

    Sardana M, Lin H, Zhang Y, Liu C, Trinquart L, Benjamin EJ, Manders ES, Fusco K, Kornej J, Hammond MM, Spartano N, Pathiravasan CH, Kheterpal V, Nowak C, Borrelli B, Murabito JM, McManus DD. Association of Habitual Physical Activity With Home Blood Pressure in the Electronic Framingham Heart Study (eFHS): Cross-sectional Study. J Med Internet Res. 2021 06 24; 23(6):e25591. PMID: 34185019.

    Read At: PubMed
  • Published on 4/8/2021

    Au R, Li J, Liu C. Au et al. Response to Body mass index and risk of dementia- potential explanations for lifecourse differences in risk estimates and future research directions. Am J Epidemiol. 2021 Apr 08. PMID: 33831143.

    Read At: PubMed
  • Published on 4/8/2021

    Li J, Joshi P, Fang T, Ang A, Liu C, Auerbach S, Devine S, Au R. Mid- to Late- Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study. Am J Epidemiol. 2021 Apr 08. PMID: 33831181.

    Read At: PubMed
  • Published on 1/26/2021

    Chen R, Aldred MA, Xu W, Zein J, Bazeley P, Comhair SAA, Meyers DA, Bleecker ER, Liu C, Erzurum SC, Hu B. Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA. Mitochondrion. 2021 05; 58:303-310. PMID: 33513442.

    Read At: PubMed
  • Published on 1/20/2021

    Pathiravasan CH, Zhang Y, Trinquart L, Benjamin EJ, Borrelli B, McManus DD, Kheterpal V, Lin H, Sardana M, Hammond MM, Spartano NL, Dunn AL, Schramm E, Nowak C, Manders ES, Liu H, Kornej J, Liu C, Murabito JM. Adherence of Mobile App-Based Surveys and Comparison With Traditional Surveys: eCohort Study. J Med Internet Res. 2021 01 20; 23(1):e24773. PMID: 33470944.

    Read At: PubMed
  • Published on 12/29/2020

    Corlin L, Liu C, Lin H, Leone D, Yang Q, Ngo D, Levy D, Cupples LA, Gerszten RE, Larson MG, Vasan RS. Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross-Sectional Analysis of the Plasma Proteome in the Framingham Heart Study. J Am Heart Assoc. 2021 01 05; 10(1):e018020. PMID: 33372532.

    Read At: PubMed
  • Published on 11/23/2020

    Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E, Aeschbacher S, Asllanaj E, Blankenberg S, Bonnycastle LL, Bork-Jensen J, Brandslund I, Braund PS, Burgess S, Cho K, Christensen C, Connell J, Mutsert R, Dominiczak AF, Dörr M, Eiriksdottir G, Farmaki AE, Gaziano JM, Grarup N, Grove ML, Hallmans G, Hansen T, Have CT, Heiss G, Jørgensen ME, Jousilahti P, Kajantie E, Kamat M, Käräjämäki A, Karpe F, Koistinen HA, Kovesdy CP, Kuulasmaa K, Laatikainen T, Lannfelt L, Lee IT, Lee WJ, Linneberg A, Martin LW, Moitry M, Nadkarni G, Neville MJ, Palmer CNA, Papanicolaou GJ, Pedersen O, Peters J, Poulter N, Rasheed A, Rasmussen KL, Rayner NW, Mägi R, Renström F, Rettig R, Rossouw J, Schreiner PJ, Sever PS, Sigurdsson EL, Skaaby T, Sun YV, Sundstrom J, Thorgeirsson G, Esko T, Trabetti E, Tsao PS, Tuomi T, Turner ST, Tzoulaki I, Vaartjes I, Vergnaud AC, Willer CJ, Wilson PWF, Witte DR, Yonova-Doing E, Zhang H, Aliya N, Almgren P, Amouyel P, Asselbergs FW, Barnes MR, Blakemore AI, Boehnke M, Bots ML, Bottinger EP, Buring JE, Chambers JC, Chen YI, Chowdhury R, Conen D, Correa A, Davey Smith G, Boer RA, Deary IJ, Dedoussis G, Deloukas P, Di Angelantonio E, Elliott P, Felix SB, Ferrières J, Ford I, Fornage M, Franks PW, Franks S, Frossard P, Gambaro G, Gaunt TR, Groop L, Gudnason V, Harris TB, Hayward C, Hennig BJ, Herzig KH, Ingelsson E, Tuomilehto J, Järvelin MR, Jukema JW, Kardia SLR, Kee F, Kooner JS, Kooperberg C, Launer LJ, Lind L, Loos RJF, Majumder AAS, Laakso M, McCarthy MI, Melander O, Mohlke KL, Murray AD, Nordestgaard BG, Orho-Melander M, Packard CJ, Padmanabhan S, Palmas W, Polasek O, Porteous DJ, Prentice AM, Province MA, Relton CL, Rice K, Ridker PM, Rolandsson O, Rosendaal FR, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sattar N, Sheu WH, Smith BH, Soranzo N, Spector TD, Starr JM, Sebert S, Taylor KD, Lakka TA, Timpson NJ, Tobin MD, van der Harst P, van der Meer P, Ramachandran VS, Verweij N, Virtamo J, Völker U, Weir DR, Zeggini E, Charchar FJ, Wareham NJ, Langenberg C, Tomaszewski M, Butterworth AS, Caulfield MJ, Danesh J, Edwards TL, Holm H, Hung AM, Lindgren CM, Liu C, Manning AK, Morris AP, Morrison AC, O'Donnell CJ, Psaty BM, Saleheen D, Stefansson K, Boerwinkle E, Chasman DI, Levy D, Newton-Cheh C, Munroe PB, Howson JMM. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2020 12; 52(12):1314-1332. PMID: 33230300.

    Read At: PubMed