Chunyu Liu
Profiles

Chunyu Liu, PhD

Professor, Biostatistics - Boston University School of Public Health

Biography

Dr. Chunyu Liu earned her PhD in Biostatistics with a specialization in statistical genetics from the Department of Biostatistics at Boston University. She embarked on her professional journey at Biogen Idec Inc. in Cambridge, Massachusetts, where she served as a statistical geneticist. Additionally, she made significant contributions to the Population Sciences Branch & Framingham Heart Study (FHS), NHLBI, located in Framingham, Massachusetts.
Throughout her career, Dr. Liu has been actively engaged in diverse projects assessing risk factors associated with cardiovascular disease (CVD) and Alzheimer’s disease (AD). Her notable portfolio includes leadership roles as the Principal Investigator (PI) for three R01 grants and an R21 grant since 2018. Moreover, she serves as a subcontract PI for two R21 grants and has secured funding from the Cure Alzheimer’s Fund. In collaborative endeavors, she plays a pivotal role as the lead biostatistician in several R01 grants, contributing to over 135 peer-reviewed manuscripts. Dr. Liu often holds significant authorship positions in these publications, including as the first, second, or last author in more than 40 papers.
Dr. Liu's contributions span significant collaborative research endeavors, where she has held key roles as the lead statistician and co-convener in multiple working groups within the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE). Currently, she serves as a co-convener of the Trans-Omics for Precision Medicine (TOPMed) Mitochondrial DNA (mtDNA) working group, leading efforts to develop analytical methods for mtDNA sequence variations.
Furthermore, Dr. Liu shares her expertise as a member of the NIH’s Genetics of Health and Disease Study Section within the Center for Scientific Review. Her commitment extends to editorial responsibilities, acting as an Associate Editor for the Cardiovascular Digital Health Journal and an Academic Editor for PLOS ONE. Additionally, she plays an active role in the International Genetic Epidemiology Society, co-chairing its Education Committee.

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University

Education

  • Boston University, PhD Field of Study: Biostatistics
  • University of Maine, PhD Field of Study: Biochemistry
  • Boston University, MA Field of Study: Biostatistics

Classes Taught

  • SPHBS800
  • SPHBS852
  • SPHBS901

Publications

  • Published on 11/16/2023

    Li Y, Wang M, Liu X, Rong J, Miller PE, Joehanes R, Huan T, Guo X, Rotter JI, Smith JA, Yu B, Nayor M, Levy D, Liu C, Ma J. Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease. BMC Med. 2023 Nov 16; 21(1):443. PMID: 37968697.

    Read At: PubMed
  • Published on 10/27/2023

    Sarnowski C, Huan T, Ma Y, Joehanes R, Beiser A, DeCarli CS, Heard-Costa NL, Levy D, Lin H, Liu CT, Liu C, Meigs JB, Satizabal CL, Florez JC, Hivert MF, Dupuis J, De Jager PL, Bennett DA, Seshadri S, Morrison AC. Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer's disease at CPT1A locus. Clin Epigenetics. 2023 Oct 27; 15(1):173. PMID: 37891690.

    Read At: PubMed
  • Published on 10/26/2023

    Wang M, Li Y, Lai M, Nannini DR, Hou L, Joehanes R, Huan T, Levy D, Ma J, Liu C. Alcohol consumption and epigenetic age acceleration across human adulthood. Aging (Albany NY). 2023 Oct 26; 15(20):10938-10971. PMID: 37889500.

    Read At: PubMed
  • Published on 10/5/2023

    Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O'Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W, Rotter JI, Lin X, Natarajan P, Peloso GM. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study. Am J Hum Genet. 2023 Oct 05; 110(10):1704-1717. PMID: 37802043.

    Read At: PubMed
  • Published on 7/14/2023

    Wang X, Pathiravasan CH, Zhang Y, Trinquart L, Borrelli B, Spartano NL, Lin H, Nowak C, Kheterpal V, Benjamin EJ, McManus DD, Murabito JM, Liu C. Association of Depressive Symptom Trajectory With Physical Activity Collected by mHealth Devices in the Electronic Framingham Heart Study: Cohort Study. JMIR Ment Health. 2023 Jul 14; 10:e44529. PMID: 37450333.

    Read At: PubMed
  • Published on 6/29/2023

    Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O'Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W, Rotter JI, Lin X, Natarajan P, Peloso GM. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study. medRxiv. 2023 Jun 29. PMID: 37425772.

    Read At: PubMed
  • Published on 3/6/2023

    Shapira-Daniels A, Kornej J, Spartano NL, Wang X, Zhang Y, Pathiravasan CH, Liu C, Trinquart L, Borrelli B, McManus DD, Murabito JM, Benjamin EJ, Lin H. Step Count, Self-reported Physical Activity, and Predicted 5-Year Risk of Atrial Fibrillation: Cross-sectional Analysis. J Med Internet Res. 2023 Mar 06; 25:e43123. PMID: 36877540.

    Read At: PubMed
  • Published on 2/10/2023

    Yuan J, Liu X, Liu C, Ang AF, Massaro J, Devine SA, Auerbach SH, Blusztajn JK, Au R, Jacques PF. Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. Am J Clin Nutr. 2022 Nov; 116(5):1201-1207. PMID: 37208066.

    Read At: PubMed
  • Published on 1/27/2023

    Ma J, Huang A, Yan K, Li Y, Sun X, Joehanes R, Huan T, Levy D, Liu C. Blood transcriptomic biomarkers of alcohol consumption and cardiovascular disease risk factors: the Framingham Heart Study. Hum Mol Genet. 2023 Jan 27; 32(4):649-658. PMID: 36130209.

    Read At: PubMed
  • Published on 1/20/2023

    Trinquart L, Liu C, McManus DD, Nowak C, Lin H, Spartano NL, Borrelli B, Benjamin EJ, Murabito JM. Increasing Engagement in the Electronic Framingham Heart Study: Factorial Randomized Controlled Trial. J Med Internet Res. 2023 Jan 20; 25:e40784. PMID: 36662544.

    Read At: PubMed

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