Karen R. Jacobson, MD, MPH

Associate Professor, Epidemiology - Boston University School of Public Health


Dr. Karen Jacobson is an Associate Professor of Medicine in the Section of Infectious Diseases, Chobanian and Avedisian School of Medicine, with a secondary appointment in the Department of Epidemiology, Boston University School of Public Health. Dr. Jacobson’s research focuses on the epidemiology of tuberculosis, including identification of biological and social determinants of and risk factors for tuberculosis infection and disease (including drug resistant tuberculosis) and approaches for improving tuberculosis outcomes in resource-limited settings. Dr. Jacobson is the Medical Director of the Boston Medical Center Tuberculosis Clinic and has established a highly productive collaboration with researchers in Cape Town, South Africa. Her work has particular emphasis in understanding how substance use impacts on tuberculosis transmission and response to therapy.

Other Positions

  • Associate Professor, Medicine - Boston University Chobanian & Avedisian School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University


  • Johns Hopkins University School of Medicine, MD Field of Study: Medicine
  • Harvard School of Public Health, MPH Field of Study: Clinical Evaluation/Research
  • Yale University, BS Field of Study: Biology


  • Published on 7/10/2024

    Wijk M, Gausi K, Malatesta S, Weber SE, Court R, Myers B, Carney T, Parry CDH, Horsburgh CR, White LF, Wiesner L, Warren RM, Uren C, McIlleron H, Kloprogge F, Denti P, Jacobson KR. The impact of alcohol and illicit substance use on the pharmacokinetics of first-line TB drugs. J Antimicrob Chemother. 2024 Jul 10. PMID: 38985541.

    Read At: PubMed
  • Published on 7/1/2024

    Savinkina A, Muyindike W, Hahn JA, Emenyonu NI, Fatch R, Ngabirano C, Adong J, Jacobson KR, Linas BP. Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. Int J Tuberc Lung Dis. 2024 Jul 01; 28(7):335-342. PMID: 38961548.

    Read At: PubMed
  • Published on 6/14/2024

    Farhat MR, Jacobson KR. For Tuberculosis, Not "To Screen or Not to Screen?" but "Who?" and "How?". Clin Infect Dis. 2024 Jun 14; 78(6):1677-1679. PMID: 38636953.

    Read At: PubMed
  • Published on 3/25/2024

    Marin MG, Wippel C, Quinones-Olvera N, Behruznia M, Jeffrey BM, Harris M, Mann BC, Rosenthal A, Jacobson KR, Warren RM, Li H, Meehan CJ, Farhat MR. Analysis of the limited M. tuberculosis accessory genome reveals potential pitfalls of pan-genome analysis approaches. bioRxiv. 2024 Mar 25. PMID: 38585972.

    Read At: PubMed
  • Published on 11/27/2023

    Shapiro AN, Scott L, Moultrie H, Jacobson KR, Bor J, Fofana AM, Dor G, Ndjeka NO, da Silva P, Mlisana K, Jenkins HE, Stevens WS. Tuberculosis testing patterns in South Africa to identify groups that would benefit from increased investigation. Sci Rep. 2023 Nov 27; 13(1):20875. PMID: 38012266.

    Read At: PubMed
  • Published on 10/10/2023

    Scott LE, Shapiro AN, Da Silva MP, Tsoka J, Jacobson KR, Emch M, Moultrie H, Jenkins HE, Moore D, Van Rie A, Stevens WS. Integrating Molecular Diagnostics and GIS Mapping: A Multidisciplinary Approach to Understanding Tuberculosis Disease Dynamics in South Africa Using Xpert MTB/RIF. Diagnostics (Basel). 2023 Oct 10; 13(20). PMID: 37891984.

    Read At: PubMed
  • Published on 9/25/2023

    Kulkarni S, Weber SE, Buys C, Lambrechts T, Myers B, Drainoni ML, Jacobson KR, Theron D, Carney T. Patient and provider perceptions of the relationship between alcohol use and TB and readiness for treatment: a qualitative study in South Africa. Res Sq. 2023 Sep 25. PMID: 37841852.

    Read At: PubMed
  • Published on 9/20/2023

    Mann BC, Jacobson KR, Ghebrekristos Y, Warren RM, Farhat MR. Assessment and validation of enrichment and target capture approaches to improve Mycobacterium tuberculosis WGS from direct patient samples. J Clin Microbiol. 2023 Oct 24; 61(10):e0038223. PMID: 37728909.

    Read At: PubMed
  • Published on 8/1/2023

    Acuña-Villaorduña C, Jacobson KR, Horsburgh CR, Canning M, Sinha P. Initial experience with BPaL-based regimens to treat multidrug-resistant TB. Int J Tuberc Lung Dis. 2023 Aug 01; 27(8):649-650. PMID: 37491751.

    Read At: PubMed
  • Published on 7/3/2023

    Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR, Salgame P, Alland D, Barry CE, Flynn JL, Ellner JJ, Wilkinson RJ. High resolution imaging and five-year tuberculosis contact outcomes. medRxiv. 2023 Jul 03. PMID: 37461515.

    Read At: PubMed

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