
Gina Marie Peloso, PhD
Associate Professor, Biostatistics - Boston University School of Public Health
Biography
Gina Peloso, PhD, is an Associate Professor in the Department of Biostatistics. Prior to joining BU, she was a post-doctoral fellow in Human Genetics at Massachusetts General Hospital and the Broad Institute. Her primary research focus is statistical genetics. She has contributed to the identification of common genetic variants through genome-wide association studies (GWAS) with complex cardiovascular traits, particularly with plasma lipid levels. She also investigates the role of rare genetic variation using both exome and whole genome sequencing. Her goals for studying genetic variation of blood lipid levels include, first, making insights into the biology behind the traits: What are the underlying causes of high/low lipid levels? Second, to use genetic variants to answer clinically meaningful questions: Can we use genetic variants to predict risk?: Does genetics point to potential therapeutic targets? Finally, to make connections between diseases by shared genetic contributions: What is the relationship between the genetics of blood lipid levels and Alzheimer’s disease (AD)? Gina is an active member in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and TOPMed Program, and a lead investigator in the Global Lipid Genetic Consortium (http://www.lipidgenetics.org/).
Other Positions
- Investigator - Framingham Heart Study
- Member, Genome Science Institute - Boston University
Education
- Boston University, PhD Field of Study: Biostatistics
- Boston University, MA Field of Study: Biostatistics
- Boston University, BA Field of Study: Biology
Classes Taught
- SPHBS852
- SPHBS858
- SPHBS943
Publications
- Published on 2/1/2025
Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler SA, Musameh MD, Nelson CP, Dasmeh P, Grover S, Knoll K, Naamanka J, Mordi IR, Braund PS, Dreßen M, Lahm H, Wirth F, Baldus S, Kelm M, von Scheidt M, Krefting J, Ellinghaus D, Small AM, Peloso GM, Natarajan P, Thanassoulis G, Engert JC, Dufresne L, Franke A, Görg S, Laudes M, Nowak-Göttl U, Vaht M, Metspalu A, Stoll M, Berger K, Pellegrini C, Kastrati A, Hengstenberg C, Lang CC, Kessler T, Hovatta I, Nickenig G, Nöthen MM, Krane M, Schunkert H, Samani NJ, Schumacher J, Kals M, Reigo A, Teder-Laving M, Gehlen J, Webb TR, Giel AS, Koebbe LL, Feirer N, Billmann M, Srinivasan S, Zimmer S, Palmer CNA, Li L, Yang C, Borisov O, Adam M, Veulemans V, Joner M, Xhepa E. Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease. JAMA Cardiol. 2025 Feb 01; 10(2):145-154. PMID: 39504041.
Read At: PubMed
- Published on 1/8/2025
Choi SH, Young R, Koyama S, Jukema JW, Trompet S, Ford I, Natarajan P, Peloso GM. Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER. JACC Adv. 2025 Feb; 4(2):101535. PMID: 39886309.
Read At: PubMed
- Published on 11/28/2024
Dron JS, Natarajan P, Peloso GM. The breadth and impact of the Global Lipids Genetics Consortium. Curr Opin Lipidol. 2024 Nov 28. PMID: 39602359.
Read At: PubMed
- Published on 11/14/2024
Zhang D, Gao B, Feng Q, Manichaikul A, Peloso GM, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Gabriel S, Gupta N, Smith JD, Aguet F, Ardlie KG, Blackwell TW, Gerszten RE, Rich SS, Rotter JI, Scott LJ, Zhou X, Lee S. Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies. HGG Adv. 2025 Jan 09; 6(1):100383. PMID: 39543875.
Read At: PubMed
- Published on 11/1/2024
Anwar MY, Highland H, Buchanan VL, Graff M, Young K, Taylor KD, Tracy RP, Durda P, Liu Y, Johnson CW, Aguet F, Ardlie KG, Gerszten RE, Clish CB, Lange LA, Ding J, Goodarzi MO, Chen YI, Peloso GM, Guo X, Stanislawski MA, Rotter JI, Rich SS, Justice AE, Liu CT, North K. Machine learning-based clustering identifies obesity subgroups with differential multi-omics profiles and metabolic patterns. Obesity (Silver Spring). 2024 Nov; 32(11):2024-2034. PMID: 39497627.
Read At: PubMed
- Published on 10/20/2024
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 Dec; 20(12):8470-8483. PMID: 39428839.
Read At: PubMed
- Published on 9/25/2024
Gunn S, Wang X, Posner DC, Cho K, Huffman JE, Gaziano M, Wilson PW, Sun YV, Peloso G, Lunetta KL. Comparison of methods for building polygenic scores for diverse populations. HGG Adv. 2025 Jan 09; 6(1):100355. PMID: 39323095.
Read At: PubMed
- Published on 9/14/2024
DeForest N, Wang Y, Zhu Z, Dron JS, Koesterer R, Natarajan P, Flannick J, Amariuta T, Peloso GM, Majithia AR. Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy. Nat Commun. 2024 Sep 14; 15(1):8068. PMID: 39277575.
Read At: PubMed
- Published on 8/6/2024
Yang TY, Small AM, Dufresne L, Peloso GM, Natarajan P, Engert JC, Thanassoulis G. Plasma Proteomic Biomarkers of Aortic Stenosis: A Mendelian Randomization Study. J Am Coll Cardiol. 2024 Aug 06; 84(6):592-594. PMID: 39084832.
Read At: PubMed
- Published on 7/25/2024
Lee J, Gilliland TC, Dron J, Koyama S, Nakao T, Lannery K, Wong M, Peloso GM, Hornsby WE, Natarajan P. Integrative Metabolomics Differentiate Coronary Artery Disease, Peripheral Artery Disease, and Venous Thromboembolism Risks. Arterioscler Thromb Vasc Biol. 2024 Sep; 44(9):2108-2117. PMID: 39051123.
Read At: PubMed
View 151 more publications:View Full Profile at BUMC
News & In the Media
-
Published on July 22, 2024
New Study Identifies Two Proteins That May Contribute to Stroke Recurrence
-
Published on March 21, 2024
Researchers Identify Novel Genetic Variants Associated with Alzheimer’s Disease
-
Published on February 16, 2022
5 Ways To Lower Dementia Risk – Even If It Runs In The Family – According To Scientists
-
Published on July 23, 2020
Genetics, Cardiovascular Health Both Contribute to Dementia Risk
- Published on March 10, 2020
-
Published on December 12, 2019
Researchers Awarded $10.8 Million to Study Genetics of Alzheimer’s
-
Published on May 15, 2019
Heart Disease Prevention May Be Linked to Rare Gene Mutation
- Published on May 10, 2019
- Published on April 8, 2019
-
Published on April 6, 2016
Single-Gene Mutations Account for Small Percent of Elevated Cholesterol Cases