Gina Peloso
Profiles

Gina Marie Peloso, PhD

Associate Professor, Biostatistics - Boston University School of Public Health

(617) 358-4466
gpeloso@bu.edu
Crosstown Center - 317
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Biography

Gina Peloso, PhD, is an Associate Professor in the Department of Biostatistics. Prior to joining BU, she was a post-doctoral fellow in Human Genetics at Massachusetts General Hospital and the Broad Institute. Her primary research focus is statistical genetics. She has contributed to the identification of common genetic variants through genome-wide association studies (GWAS) with complex cardiovascular traits, particularly with plasma lipid levels. She also investigates the role of rare genetic variation using both exome and whole genome sequencing. Her goals for studying genetic variation of blood lipid levels include, first, making insights into the biology behind the traits: What are the underlying causes of high/low lipid levels? Second, to use genetic variants to answer clinically meaningful questions: Can we use genetic variants to predict risk?: Does genetics point to potential therapeutic targets? Finally, to make connections between diseases by shared genetic contributions: What is the relationship between the genetics of blood lipid levels and Alzheimer’s disease (AD)? Gina is an active member in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and TOPMed Program, and a lead investigator in the Global Lipid Genetic Consortium (http://www.lipidgenetics.org/).

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Genome Science Institute - Boston University

Education

  • Boston University, PhD Field of Study: Biostatistics
  • Boston University, MA Field of Study: Biostatistics
  • Boston University, BA Field of Study: Biology

Websites

Classes Taught

  • SPHBS852
  • SPHBS858
  • SPHBS943

Publications

  • Published on 5/25/2026

    Koyama S, Yu Z, Choi SH, Jurgens SJ, Selvaraj MS, Klarin D, Huffman JE, Clarke SL, Zhang SK, Trinh MN, Ravi A, Dron JS, Spinks C, Surakka I, Bhatnagar A, Lannery K, Hornsby W, Damrauer SM, Chang KM, Lynch JA, Assimes TL, Tsao PS, Rader DJ, Cho K, Peloso GM, Ellinor PT, Sun YV, Wilson PWF, Natarajan P. Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations. Nat Genet. 2026 May 25. PMID: 42185625.

     Read At: PubMed
  • Published on 5/9/2026

    Li L, Alaa A, Tan Y, Demirel I, Friedman S, Zha Q, Tracy R, Taylor KD, Yu B, Ballantyne CM, Deo R, Dubin R, Tsai MY, Peloso GM, Brody J, Austin T, Psaty BM, Nicholas J, Raffield LM, Tahir U, Coresh J, Hornsby W, Chan A, Rich SS, Rotter JI, Ganz P, Gerszten R, Philippakis A, Natarajan P, Yu Z. Machine learning cross-platform proteomic imputation enables protein quality scoring and replication of epidemiological associations. bioRxiv. 2026 May 09. PMID: 42146637.

     Read At: PubMed
  • Published on 4/30/2026

    Huang YJ, Kurniansyah N, Goodman MO, Spitzer BW, Wang J, Stilp A, Laurie C, de Vries PS, Chen H, Min YI, Sims M, Peloso GM, Guo X, Bis JC, Brody JA, Raffield LM, Smith JA, Zhao W, Rotter JI, Rich SS, Redline S, Fornage M, Kaplan R, Franceschini N, Levy D, Morrison AC, Boerwinkle E, Smith NL, Kooperberg C, Psaty BM, Zöllner S, Sofer T. Admixture-informed polygenic risk reporting using the ePRS framework. Nat Commun. 2026 Apr 30. PMID: 42062286.

     Read At: PubMed
  • Published on 4/23/2026

    Peloso GM, Wang D, Abbruzzese SM, Bis JC, Choi SH, Beiser A, Bressler J, Dupuis J, Fohner AE, Ghanbari M, Gibbs RA, Heard-Costa N, Ikram MA, Lacaze P, Le Grand Q, Lopez OL, Mosley TH, Riaz M, Soumaré A, Yaqub A, Boerwinkle E, Psaty BM, Fornage M, Seshadri S, DeStefano AL. Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old. J Alzheimers Dis. 2026 Apr 23; 13872877261444302. PMID: 42024100.

     Read At: PubMed
  • Published on 4/22/2026

    Peloso GM, Adhikari N, Young MM, Cho K, Kinlay S. Genome-Wide Association Study of Chronic Venous Insufficiency and Lymphedema in the Million Veteran Program. Circ Genom Precis Med. 2026 Apr 22; e005442. PMID: 42017216.

     Read At: PubMed
  • Published on 4/1/2026

    Spinks C, Selvaraj MS, Robinson C, Peloso GM, Gwynne C, Urbut S, Truong B, Paruchuri K, Hornsby W, Natarajan P. Management and Consequences of Genotype-Positive Familial Hypercholesterolemia. JAMA Cardiol. 2026 Apr 01; 11(4):378-382. PMID: 41779414.

     Read At: PubMed
  • Published on 3/19/2026

    Palatsides EL, Himali D, Cribb L, Peloso GM, Ryan J, Yang Q, Decarli CS, Beiser AS, Seshadri S, Cavuoto MG, Yiallourou S, Baril AA, Himali JJ, Pase MP. Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia. Neurology. 2026 Apr 14; 106(7):e214773. PMID: 41855452.

     Read At: PubMed
  • Published on 3/17/2026

    Adhikari N, Lunetta KL, Gagnon DR, Peloso GM. Bayesian Mendelian randomization methods for index trait bias correction in subsequent trait genome-wide association studies. HGG Adv. 2026 Mar 17; 7(3):100592. PMID: 41846316.

     Read At: PubMed
  • Published on 2/16/2026

    Harper C, Misra A, Patel AP, Cho SM, Koyama S, Peloso GM, Hornsby W, Nakao T, Natarajan P. Polygenic risk scores enhance LDL cholesterol-based risk stratification for coronary artery disease. Am J Prev Cardiol. 2026 Apr; 26:101487. PMID: 42006434.

     Read At: PubMed
  • Published on 1/20/2026

    Wang D, Abbruzzese S, Heard-Costa N, Rampersaud A, Martin E, Naj A, Akgun B, Kunkle B, Seshadri S, Peloso G, DeStefano AL, Li Z, Li X, Choi SH. Application of the STAAR framework in detecting rare variant associations with Alzheimer disease and related dementias: Insights and implications. HGG Adv. 2026 Apr 09; 7(2):100574. PMID: 41560352.

     Read At: PubMed

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