Gina Peloso
Profiles

Gina Marie Peloso, PhD

Associate Professor, Biostatistics - Boston University School of Public Health

(617) 358-4466
gpeloso@bu.edu
Crosstown Center - 317
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Biography

Gina Peloso, PhD, is an Associate Professor in the Department of Biostatistics. Prior to joining BU, she was a post-doctoral fellow in Human Genetics at Massachusetts General Hospital and the Broad Institute. Her primary research focus is statistical genetics. She has contributed to the identification of common genetic variants through genome-wide association studies (GWAS) with complex cardiovascular traits, particularly with plasma lipid levels. She also investigates the role of rare genetic variation using both exome and whole genome sequencing. Her goals for studying genetic variation of blood lipid levels include, first, making insights into the biology behind the traits: What are the underlying causes of high/low lipid levels? Second, to use genetic variants to answer clinically meaningful questions: Can we use genetic variants to predict risk?: Does genetics point to potential therapeutic targets? Finally, to make connections between diseases by shared genetic contributions: What is the relationship between the genetics of blood lipid levels and Alzheimer’s disease (AD)? Gina is an active member in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and TOPMed Program, and a lead investigator in the Global Lipid Genetic Consortium (http://www.lipidgenetics.org/).

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Genome Science Institute - Boston University

Education

  • Boston University, PhD Field of Study: Biostatistics
  • Boston University, MA Field of Study: Biostatistics
  • Boston University, BA Field of Study: Biology

Websites

Classes Taught

  • SPHBS852
  • SPHBS858
  • SPHBS943

Publications

  • Published on 12/31/2025

    Van Buren E, Zhang Y, Li X, Selvaraj MS, Li Z, Zhou H, Palmer ND, Arnett DK, Blangero J, Boerwinkle E, Cade BE, Carlson JC, Carson AP, Chen YI, Curran J, Duggirala R, Fornage M, Franceschini N, Graff M, Gu C, Guo X, He J, Heard-Cosa N, Hou L, Hung YJ, Kalyani RR, Kardia SLR, Kenny E, Kooperberg C, Kral BG, Lange L, Levy D, Li C, Liu S, Lloyd-Jones D, Loos RJF, Manichaikul AW, Martin LW, Mathias R, Minster RL, Mitchell BD, Mychaleckyj JC, Naseri T, North K, O'Connell J, Perry JA, Peyser PA, Psaty BM, Raffield LM, Vasan RS, Redline S, Reiner AP, Rich SS, Smith JA, Spitzer B, Tang H, Taylor KD, Tracy R, Viali S, Yanek L, Zhao W, Rotter JI, Peloso GM, Natarajan P, Lin X. cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions. Nat Methods. 2025 Dec 31. PMID: 41476111.

     Read At: PubMed
  • Published on 12/19/2025

    Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, Sveinbjornsson G, Gudbjartsson DF, Abner E, Lee J, Ganna A, Nowak-Göttl U, Finer S, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreßen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O'Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction. Nat Genet. 2026 Jan; 58(1):57-66. PMID: 41419686.

     Read At: PubMed
  • Published on 12/9/2025

    Ferolito BR, Dashti H, Giambartolomei C, Peloso GM, Golden DJ, Gravel-Pucillo K, Rasooly D, Horimoto ARVR, Matty R, Gaziano L, Liu Y, Smit IA, Zdrazil B, Tsepilov Y, Costa L, Kosik N, Huffman JE, Tartaglia GG, Bini G, Proietti G, Ioannidis H, Karim MA, Hunter F, Hemani G, Butterworth AS, Di Angelantonio E, Langenberg C, Ghoussaini M, Leach AR, Liao KP, Damrauer S, Selva LE, Whitbourne S, Tsao PS, Moser J, Gaunt T, Cai T, Whittaker JC, Casas JP, Muralidhar S, Gaziano JM, Cho K, Pereira AC. Leveraging large-scale biobanks for therapeutic target discovery. HGG Adv. 2025 Dec 09; 7(1):100556. PMID: 41376171.

     Read At: PubMed
  • Published on 11/27/2025

    Yu Z, Vromman A, Nguyen NQH, Schuermans A, Li L, Rentz T, Nakao T, Vellarikkal SK, Uddin MM, Niroula A, Griffin G, Honigberg MC, Lin AE, Gibson CJ, Katz DH, Tahir UA, Fang S, Dron JS, Pan M, Haidermota S, Ganesh S, Antoine T, Weinstock J, Austin TR, Vasan RS, Peloso GM, Hornsby W, Ganz P, Manson JE, Haring B, Kooperberg C, Reiner AP, Bis JC, Psaty BM, Min YI, Correa A, Lange LA, Post WS, Rotter JI, Rich SS, Wilson JG, Ebert BL, Yu B, Ballantyne CM, Coresh J, Sankaran VG, Bick AG, Jaiswal S, Gerszten RE, Libby P, Gupta RM, Natarajan P. Human plasma proteomic profile of clonal hematopoiesis. Nat Commun. 2025 Nov 27; 16(1):11688. PMID: 41309676.

     Read At: PubMed
  • Published on 10/28/2025

    Urbut SM, Chen Q, Sui Y, Misra A, Koyama S, Hornsby W, Peloso GM, Finer S, van Heel DA, Ito K, Alkuraya F, Fahed AC, Wang M, Natarajan P. Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries. NEJM Evid. 2025 Nov; 4(11):EVIDoa2500105. PMID: 41147828.

     Read At: PubMed
  • Published on 9/9/2025

    Selvaraj MS, Li X, Li Z, Van Buren E, Haidermota S, Postupaka D, Hornsby W, Bis JC, Brody JA, Cade BE, Chung RH, Curran JE, Damrauer SM, de Las Fuentes L, de Vries PS, Duggirala R, Freedman BI, Graff M, Guo X, Hidalgo BA, Hou L, Irvin R, Judy R, Kalyani RR, Kelly TN, Konigsberg IR, Kral BG, Kwee LC, Levy D, Li C, Manichaikul AW, Martin LW, Montasser ME, Morrison AC, Naseri T, North KE, O'Connell JR, Palmer ND, Peyser PA, Reiner AP, Shah SH, Smit RAJ, Smith JA, Taylor KD, Tiwari H, Tsai MY, Viali S, Wang Z, Wang Y, Zhao W, Arnett DK, Blangero J, Boerwinkle E, Bowden DW, Carlson JC, Chen YI, Ellinor PT, Fornage M, He J, Heard-Costa N, Kaplan RC, Kardia SLR, Kooperberg C, Kraus WE, Lange LA, Loos RJF, Mitchell BD, Psaty BM, Rader DJ, Redline S, Rich SS, Yanek LR, Gibbs R, Gabriel S, Viaud-Martinez KA, Dutcher SK, Germer S, Kim R, Rotter JI, Lin X, Peloso GM, Natarajan P. Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals. Genome Biol. 2025 Sep 09; 26(1):273. PMID: 40926209.

     Read At: PubMed
  • Published on 8/29/2025

    Mohammadnia N, Xue L, Vestjens LTW, Uddin MM, Niroula A, de Kleijn DPV, Mosterd A, Fiolet ATL, Nakao T, Eikelboom JW, Cetinyurek-Yavuz A, Peloso GM, Bax WA, Riksen NP, Natarajan P, Cornel JH, El Messaoudi S, Honigberg MC. Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. J Am Coll Cardiol. 2025 Nov 25; 86(21):1983-1996. PMID: 40892620.

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  • Published on 7/3/2025

    Lioutas VA, Peloso G, Romero JR, Aparicio H, Gonzales M, Werry A, Himali D, Himali J, Banerjee A, Gosh S, Ramachandran VS, Beiser A, Seshadri S. Long-Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study. J Am Heart Assoc. 2025 Jul 15; 14(14):e037817. PMID: 40611491.

     Read At: PubMed
  • Published on 7/3/2025

    Bhattacharya R, Marnell CS, Cho SMJ, Patel AP, Ruan Y, Koyama S, Jowell AR, Trinder M, Haidermota S, Lannery K, Honigberg MC, Zekevat SM, Surakka I, Peloso GM, Natarajan P. Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD. Circ Genom Precis Med. 2025 Aug; 18(4):e004937. PMID: 40605734.

     Read At: PubMed
  • Published on 7/3/2025

    Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. Front Syst Biol. 2025; 5. PMID: 40766210.

     Read At: PubMed

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