Jayandra Himali
Profiles

Jayandra Jung Himali, PhD

Adjunct Associate Professor, Neurology - Boston University Chobanian & Avedisian School of Medicine

Biography

Jayandra Jung Himali, PhD, serves as an adjunct Associate Professor of Neurology and Biostatistics at Boston University Schools of Medicine and of Public Health, and a Center Faculty Member of the Framingham Heart Study (FHS). He has been engaged in collaborative public health research and teaching for over a decade. As a senior Biostatistician at the Neurology core of FHS, his research efforts are focused on the interrelated areas of: (1) the epidemiology of dementia and Alzheimer’s disease (AD) and relating traditional and novel biomarkers to the risk of dementia and AD; (2) the epidemiology of stroke and vascular cognitive impairment; (3) understanding vascular contributions to cognitive impairment and dementia including AD; and (4) investigating the role of modifiable lifestyle factors: sleep, diet and physical activity on the incidence of dementia, cognitive decline and MRI-defined brain aging. His research is also focused on outcome assessment in Epilepsy, Parkinson’s disease, and neuropathology. He has received the Nepal Bidhya Bhusan Class ‘A’ Medal from the government of Nepal for highest academic achievement in doctoral studies.

Other Positions

  • Investigator - Framingham Heart Study

Education

  • Boston University School of Public Health, PhD Field of Study: Biostatistics
  • Tribhuvan University, MSc Field of Study: Statistics
  • Tribhuvan University, BSc Field of Study: Statistics

Publications

  • Published on 5/1/2024

    DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024 May 01; 81(5):471-480. PMID: 38526486.

    Read At: PubMed
  • Published on 2/1/2024

    Krefman AE, Stephen J, Carolan P, Sedaghat S, Mansolf M, Soumare A, Gross AL, Aiello AE, Singh-Manoux A, Ikram MA, Helmer C, Tzourio C, Satizabal C, Levine DA, Lloyd-Jones D, Briceño EM, Sorond FA, Wolters FJ, Himali J, Launer LJ, Zhao L, Haan M, Lopez OL, Debette S, Seshadri S, Judd SE, Hughes TM, Gudnason V, Scholtens D, Allen NB. Cohort Profile: Dementia Risk Prediction Project (DRPP). Int J Epidemiol. 2024 Feb 01; 53(1). PMID: 38339864.

    Read At: PubMed
  • Published on 1/30/2024

    Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075. PMID: 38290090.

    Read At: PubMed
  • Published on 12/13/2023

    Baril AA, Kojis DJ, Himali JJ, Decarli CS, Sanchez E, Johnson KA, El Fakhri G, Thibault E, Yiallourou SR, Himali D, Cavuoto MG, Pase MP, Beiser AS, Seshadri S. Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology. Neurology. 2024 Jan 09; 102(1):e207807. PMID: 38165370.

    Read At: PubMed
  • Published on 12/1/2023

    Himali JJ, Baril AA, Cavuoto MG, Yiallourou S, Wiedner CD, Himali D, DeCarli C, Redline S, Beiser AS, Seshadri S, Pase MP. Association Between Slow-Wave Sleep Loss and Incident Dementia. JAMA Neurol. 2023 Dec 01; 80(12):1326-1333. PMID: 37902739.

    Read At: PubMed
  • Published on 8/22/2023

    Melo van Lent D, Mesa HG, Short MI, Gonzales MM, Aparicio HJ, Salinas J, Yuan C, Jacques PF, Beiser A, Seshadri S, Jacob ME, Himali JJ. Association between dietary inflammatory index score and incident dementia: results from the Framingham heart Study offspring cohort. medRxiv. 2023 Aug 22. PMID: 37662354.

    Read At: PubMed
  • Published on 8/21/2023

    Fongang B, Satizabal C, Kautz TF, Wadop YN, Muhammad JAS, Vasquez E, Mathews J, Gireud-Goss M, Saklad AR, Himali J, Beiser A, Cavazos JE, Mahaney MC, Maestre G, DeCarli C, Shipp EL, Vasan RS, Seshadri S. Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study. Sci Rep. 2023 Aug 21; 13(1):13622. PMID: 37604954.

    Read At: PubMed
  • Published on 7/3/2023

    Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril AA, Yiallourou S, Bisson A, Himali D, Leng Y, Yang Q, Seshadri S, Beiser A, Gottesman RF, Redline S, Lopez O, Lutsey PL, Yaffe K, Stone KL, Purcell SM, Himali JJ. Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults. JAMA Netw Open. 2023 Jul 03; 6(7):e2325152. PMID: 37462968.

    Read At: PubMed
  • Published on 4/17/2023

    Duperron MG, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Trégouët DA, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bülow R, Carrera C, Chen C, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Muñoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdés Hernández MC, Vernooij MW, Völker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023 Apr; 29(4):950-962. PMID: 37069360.

    Read At: PubMed
  • Published on 3/1/2023

    Nichols E, Merrick R, Hay SI, Himali D, Himali JJ, Hunter S, Keage HAD, Latimer CS, Scott MR, Steinmetz JD, Walker JM, Wharton SB, Wiedner CD, Crane PK, Keene CD, Launer LJ, Matthews FE, Schneider J, Seshadri S, White L, Brayne C, Vos T. The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. Lancet Healthy Longev. 2023 Mar; 4(3):e115-e125. PMID: 36870337.

    Read At: PubMed

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