Mark Logue
Profiles

Mark W Logue, PhD

Professor, Biostatistics - Boston University School of Public Health

(857) 364-5665
Crosstown Center
View Full Profile at BUMC

Biography

My research involves the use of computational tools to search the human genome for genetic variants influencing risk of psychiatric and neurological disorders including panic disorder, post-traumatic stress disorder, and Alzheimer’s disease. The genetics of these traits is complex, as multiple genes interact with environmental factors to determine an individual’s risk. When studying psychiatric traits, this complexity is compounded because psychiatric disorders are not distinct at the genetic level. For example, genetic variants that increase risk of developing panic disorder may also predispose an individual to bipolar disorder or phobias. To unravel this complexity, information must be integrated from a variety of sources, including families with a multiple affected individuals, large case-control study samples, and samples from different ancestral populations. The type of genetic data that can be examined is similarly diverse and can include microsatellite markers, single nucleotide polymorphisms, and base-pair level sequence data. By leveraging these multiple sources of data, and by using analysis methods that allow for this complexity at both the genetic and trait level, the presence of disease can be correlated with variants across multiple genes. The identification of these variants can implicate new biological systems or molecular pathways which are disrupted, potentially resulting in the development of new biomarkers of disease, new treatments, or personalized therapies based on a patient’s genetic profile.

Other Positions

  • Professor, Psychiatry - Boston University Chobanian & Avedisian School of Medicine
  • Investigator - Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University
  • Statistician, National Center for PTSD - VA Boston Healthcare System
  • Member, Genome Science Institute - Boston University

Education

  • University of Iowa, PhD Field of Study: Statistics
  • University of Iowa, MS Field of Study: Statistics
  • University of Oregon, BS Field of Study: Mathematics

Websites

Publications

  • Published on 5/28/2026

    Clark AL, Valocchi E, McGill MB, Lopez FV, Chanfreau-Coffinier C, Thomas KR, Jester DJ, Logue MW, Merritt VC. Examining the additive risk of TBI and comorbid conditions on dementia in military veterans: a retrospective cohort study. Alzheimers Res Ther. 2026 May 28. PMID: 42210358.

     Read At: PubMed
  • Published on 5/7/2026

    Sherva R, Bayly H, Zhang R, Harrington K, Mez J, Miller MW, Tsuang D, Wolf E, Zeng Q, Le Guen Y, Tejeda M, Gaziano JM, Panizzon MS, Hauger RL, Merritt VC, Farrer LA, Logue MW. A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci. medRxiv. 2026 May 07. PMID: 42145619.

     Read At: PubMed
  • Published on 3/10/2026

    Clark AL, Asimakopoulos G, Valocchi E, Chanfreau-Coffinier C, McGill M, Thomas KR, Jester DJ, Logue MW, Merritt VC. Individual-Level Factors Associated With 10-Year Incidence of Alzheimer Disease and Related Dementias in the VA Million Veteran Program. Neurology. 2026 Apr 14; 106(7):e214748. PMID: 41805402.

     Read At: PubMed
  • Published on 1/12/2026

    Wolf EJ, Zhao X, Madison A, Carbaugh J, Fortier CB, Milberg WP, Logue MW, Miller MW. Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene. Psychoneuroendocrinology. 2026 Apr; 186:107753. PMID: 41547340.

     Read At: PubMed
  • Published on 11/25/2025

    Wolf EJ, Zhao X, Madison A, Carbaugh J, Fortier CB, Milberg WP, Logue MW, Miller MW. Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene. medRxiv. 2025 Nov 25. PMID: 41358302.

     Read At: PubMed
  • Published on 10/13/2025

    Uffelmann E, Wightman DP, Bahrami S, Shadrin AA, Fominykh V, Ojima T, Jiang C, Benner C, Moreno E, Campos AI, Thomassen JQ, Minois-Genin E, Wu HM, Walters GB, Sherva R, Lin T, Bryois J, Krebs K, Schipper M, Narita A, Serretti A, Simonsen AH, van Seumeren AL, Corbett A, Knapskog AB, Hartmann AM, den Braber A, van Harten AC, Harder A, Rongve A, Madsen BO, Tijms BM, Aagaard B, Lichtwarck B, Kirsebom BE, Creese B, Reynolds CA, Hägg S, Karlsson I, Erikstrup C, Mikkelsen C, Ballard C, Aarsland D, Shigemizu D, Rujescu D, Gudbjartsson D, Aakhus E, Sørensen E, Stordal E, Duits FH, Wolters FJ, Blanc F, Biessels GJ, Selbæk G, Bråthen G, Tamiya G, Waldemar G, Seelaar H, Eyjolfsdottir H, Holstege H, Bundgaard H, Zetterberg H, Ullum H, Skoog I, Medbøen IT, Saltvedt I, Feiring IH, Rektorova I, Gaziano JM, Haavik J, Hjerling-Leffler J, Luo J, Snaedal J, Vijverberg EGB, Sealock JM, Blennow K, Nordengen K, Persson K, Scheffler K, Matsuda K, Ozaki K, Pihlstrøm L, Athanasiu L, Pålhaugen L, Hulsman M, Waern M, Averina M, Wettergreen M, Moksnes MR, Huisman M, Yamamoto M, Toft M, Panizzon MS, Bruun MT, Ghanbari M, Franc M, Pedersen NL, Bell NY, Tesi N, Pedersen OB, Frei O, Bousiges O, Svenningsson P, Visser PJ, Li QS, Hauger R, Zhang R, Namba S, Sando SB, Kern S, Djurovic S, Thordardottir S, Phung TN, Truelsen T, Werge T, Hansen TF, Kyosaka T, Engstad T, Fladby T, Merritt V, Bergh S, van der Flier WM, Wang R, Stahl EA, Hooli B, Davis LK, Logue MW, Lehto K, Zettergren A, Brumpton BM, Zeng J, Visscher PM, O'Reilly PF, Mahajan A, Ferreira M, Okada Y, van der Lee SJ, Ostrowski SR, Frikke-Schmidt R, Stefansson H, Heilbron K, Andreassen OA, Posthuma D. Genomic analyses reveal new insights into Alzheimer's disease. medRxiv. 2025 Oct 13. PMID: 41282776.

     Read At: PubMed
  • Published on 10/1/2025

    Logue MW, Labadorf A, O'Neill NK, Dickson DW, Dugger BN, Flanagan ME, Frosch MP, Gearing M, Jin LW, Kofler J, Mayeux R, McKee A, Miller CA, Murray ME, Nelson PT, Perrin RJ, Schneider JA, Stein TD, Teich AF, Tobunluepop K, Troncoso JC, Wang SH, Wang Z, Wolozin B, Mez J, Farrer LA. Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. Alzheimers Dement. 2025 Oct; 21(10):e70629. PMID: 41059714.

     Read At: PubMed
  • Published on 9/27/2025

    Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush W, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GC, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv. 2025 Sep 27. PMID: 41040715.

     Read At: PubMed
  • Published on 9/19/2025

    Brown K, Shutes-David A, Wilson K, Shao Y, Logue M, Zeng QT, Tsuang DW. Machine learning-based risk scores are associated with conversion to dementia in Veterans. J Alzheimers Dis. 2025 Nov; 108(2):873-882. PMID: 40971323.

     Read At: PubMed
  • Published on 9/10/2025

    Miller MW, Zhao X, Wolf EJ, Milberg WP, Fortier CB, Logue MW. Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD. Mol Psychiatry. 2026 Jan; 31(1):352-361. PMID: 40931166.

     Read At: PubMed

View 174 more publications:View Full Profile at BUMC

News & In the Media

View all profiles