Researchers Identify New Gene Linked to PTSD.
Investigators at the BU schools of Medicine and Public Health and the Veterans Affairs Boston Healthcare System have identified a new gene linked to post-traumatic stress disorder (PTSD).
The findings, published online in Molecular Psychiatry, indicate that a gene known to play a role in protecting brain cells from the damaging effects of stress may also be involved in the development of PTSD. The article reports the first positive results of a genome-wide association study of PTSD, suggesting that variations in the retinoid-related orphan receptor alpha (RORA) gene are linked to the development of PTSD.
Mark W. Miller, associate professor at BUSM and a clinical research psychologist at the National Center for PTSD at VA Boston Healthcare System, was the study’s principal investigator. Mark Logue, research assistant professor at BUSM and BUSPH, and Clinton Baldwin, professor at BUSM, were first authors of the paper.
PTSD is a psychiatric disorder defined by serious changes in cognitive, emotional, behavioral and psychological functioning that can occur in response to a psychologically traumatic event. Previous studies have estimated that approximately eight percent of the U.S. population will develop PTSD in their lifetime. That number is significantly greater among combat veterans returning from the wars in Iraq and Afghanistan, with studies estimating that 20 to 30 percent have PTSD.
Previous genome-wide studies have linked the RORA gene to other psychiatric conditions, including attention-deficit hyperactivity disorder, bipolar disorder, autism and depression.
“Like PTSD, all of these conditions have been linked to alterations in brain functioning, so it is particularly interesting that one of the primary functions of RORA is to protect brain cells from the damaging effects of oxidative stress, hypoxia and inflammation,” said Miller.
Participants in the study were approximately 500 male and female veterans and their intimate partners, all of whom had experienced trauma and approximately half of whom had PTSD. The majority of the veterans had been exposed to trauma related to their military experience, while their intimate partners had experienced trauma related to other experiences, such as sexual or physical assault, serious accidents, or the sudden death of a loved one. Each participant was interviewed by a trained clinician, and DNA was extracted from blood samples.
The DNA analysis examined approximately 1.5 million genetic markers for signs of association with PTSD and revealed a highly significant association with a variant (rs8042149) in the RORA gene. The researchers then looked for evidence of replication using data from the Detroit Neighborhood Health Study, where they also found a significant, though weaker, association between RORA and PTSD.
“These results suggest that individuals with the RORA risk variant are more likely to develop PTSD following trauma exposure, and point to a new avenue for research on how the brain responds to trauma,” said Miller.
The study was supported by the National Institute on Mental Health of the National Institutes of Health and the Department of Veterans Affairs.
submitted by: Lisa Chedekel
chedekel@bu.edu