Kathryn Lunetta
Profiles

Kathryn L. Lunetta, PhD

Professor, Biostatistics - Boston University School of Public Health

617-358-2589
klunetta@bu.edu
Crosstown Center - 313
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Biography

Kathryn L. Lunetta, Ph.D. is a Professor of Biostatistics and a statistical geneticist with more than 20 years of experience in statistics and genetics research. She has extensive experience with the design and analysis of genome- wide association studies and sequencing studies and collaborate on several large, national and international genetic epidemiology studies at Boston University and with the Framingham Heart study. Her methodological research focuses on statistical problems and study design and analysis issues in human genetics, particularly in the mapping of complex genetic diseases. Her collaborative work spans several fields, including the genetics of atrial fibrillation and related phenotypes, the genetics of healthy aging and reproduction, and Alzheimer disease. She is a member of the CHARGE (Cohorts for Heart and Aging Research) consortium and participates on the Steering and Analysis committees, and also a TOPMed investigator and analysis committee member. She is senior/primary statistician on several Alzheimer Disease related projects and for the Framingham Heart Study Atrial Fibrillation working groups, where she advises on methodology and long-term goals and provide day- to-day supervision of analyses. She is multi-PI of a Framingham Immune cell and brain aging project that seeks to identify immune cell and inflammatory biomarkers related to cognitive aging.

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Genome Science Institute - Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University

Education

  • University of Michigan at Ann Arbor, PhD Field of Study: Biostatistics
  • University of Michigan at Ann Arbor, MS Field of Study: Biostatistics
  • Grinnell College, BA Field of Study: Sociology

Websites

Classes Taught

  • SPHBS859

Publications

  • Published on 10/23/2024

    Tong T, Zhu C, Farrell JJ, Khurshid Z, Martin ER, Pericak-Vance MA, Wang LS, Bush WS, Schellenberg GD, Haines JL, Qiu WQ, Lunetta KL, Farrer LA, Zhang X. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther. 2024 Oct 23; 16(1):234. PMID: 39444005.

     Read At: PubMed
  • Published on 10/1/2024

    Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Oct 01; 81(10):993-1002. PMID: 38959008.

     Read At: PubMed
  • Published on 9/25/2024

    Gunn S, Wang X, Posner DC, Cho K, Huffman JE, Gaziano M, Wilson PW, Sun YV, Peloso G, Lunetta KL. Comparison of methods for building polygenic scores for diverse populations. HGG Adv. 2024 Sep 25; 6(1):100355. PMID: 39323095.

     Read At: PubMed
  • Published on 9/16/2024

    Chen J, Ragab AAY, Doyle MF, Alosco ML, Fang Y, Mez J, Satizabal CL, Qiu WQ, Murabito JM, Lunetta KL. Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort. Alzheimers Dement. 2024 Nov; 20(11):7465-7478. PMID: 39282876.

     Read At: PubMed
  • Published on 8/29/2024

    Jurgens SJ, Wang X, Choi SH, Weng LC, Koyama S, Pirruccello JP, Nguyen T, Smadbeck P, Jang D, Chaffin M, Walsh R, Roselli C, Elliott AL, Wijdeveld LFJM, Biddinger KJ, Kany S, Rämö JT, Natarajan P, Aragam KG, Flannick J, Burtt NP, Bezzina CR, Lubitz SA, Lunetta KL, Ellinor PT. Rare coding variant analysis for human diseases across biobanks and ancestries. Nat Genet. 2024 Sep; 56(9):1811-1820. PMID: 39210047.

     Read At: PubMed
  • Published on 8/1/2024

    Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polašek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de Gonzalez A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolcic I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widen E, Wilson JF, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK. Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nat Genet. 2024 Aug; 56(8):1763-1764. PMID: 38982295.

     Read At: PubMed
  • Published on 7/1/2024

    Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polašek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de Gonzalez A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolcic I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widen E, Wilson JF, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK. Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nat Genet. 2024 Jul; 56(7):1397-1411. PMID: 38951643.

     Read At: PubMed
  • Published on 6/12/2024

    Ragab AAY, Doyle MF, Chen J, Fang Y, Lunetta KL, Murabito JM. Immune cell phenotypes and mortality in the Framingham Heart Study. Immun Ageing. 2024 Jun 12; 21(1):37. PMID: 38867269.

     Read At: PubMed
  • Published on 5/21/2024

    Pirruccello JP, Di Achille P, Choi SH, Rämö JT, Khurshid S, Nekoui M, Jurgens SJ, Nauffal V, Kany S, Ng K, Friedman SF, Batra P, Lunetta KL, Palotie A, Philippakis AA, Ho JE, Lubitz SA, Ellinor PT. Deep learning of left atrial structure and function provides link to atrial fibrillation risk. Nat Commun. 2024 May 21; 15(1):4304. PMID: 38773065.

     Read At: PubMed
  • Published on 4/26/2024

    Gunn S, Lunetta KL. Correlation-based tests for the formal comparison of polygenic scores in multiple populations. PLoS Genet. 2024 Apr; 20(4):e1011249. PMID: 38669290.

     Read At: PubMed

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