Chunyu Liu
Profiles

Chunyu Liu, PhD

Professor, Biostatistics - Boston University School of Public Health

(617) 638-5104
liuc@bu.edu
Talbot
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Biography

Dr. Chunyu Liu earned her PhD in Biostatistics with a specialization in statistical genetics from the Department of Biostatistics at Boston University. She embarked on her professional journey at Biogen Idec Inc. in Cambridge, Massachusetts, where she served as a statistical geneticist. Additionally, she made significant contributions to the Population Sciences Branch & Framingham Heart Study (FHS), NHLBI, located in Framingham, Massachusetts.
Throughout her career, Dr. Liu has been actively engaged in diverse projects assessing risk factors associated with cardiovascular disease (CVD) and Alzheimer’s disease (AD). Her notable portfolio includes leadership roles as the Principal Investigator (PI) for three R01 grants and an R21 grant since 2018. Moreover, she serves as a subcontract PI for two R21 grants and has secured funding from the Cure Alzheimer’s Fund. In collaborative endeavors, she plays a pivotal role as the lead biostatistician in several R01 grants, contributing to over 135 peer-reviewed manuscripts. Dr. Liu often holds significant authorship positions in these publications, including as the first, second, or last author in more than 40 papers.
Dr. Liu's contributions span significant collaborative research endeavors, where she has held key roles as the lead statistician and co-convener in multiple working groups within the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE). Currently, she serves as a co-convener of the Trans-Omics for Precision Medicine (TOPMed) Mitochondrial DNA (mtDNA) working group, leading efforts to develop analytical methods for mtDNA sequence variations.
Furthermore, Dr. Liu shares her expertise as a member of the NIH’s Genetics of Health and Disease Study Section within the Center for Scientific Review. Her commitment extends to editorial responsibilities, acting as an Associate Editor for the Cardiovascular Digital Health Journal and an Academic Editor for PLOS ONE. Additionally, she plays an active role in the International Genetic Epidemiology Society, co-chairing its Education Committee.

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University

Education

  • Boston University, PhD Field of Study: Biostatistics
  • University of Maine, PhD Field of Study: Biochemistry
  • Boston University, MA Field of Study: Biostatistics

Websites

Classes Taught

  • SPHBS800
  • SPHBS852
  • SPHBS901

Publications

  • Published on 12/17/2025

    Paul TJ, Sadaniantz K, Soni A, Asaker JC, Pathiravasan CH, Mehawej J, Filippaios A, Zhang Y, Wang Z, Liu C, Lin H, Murabito JM, McManus DD, Kovell LC. Patterns of adherence to home blood pressure monitoring among men and women in the Electronic Framingham Heart Study. PLoS One. 2025; 20(12):e0337284. PMID: 41406142.

     Read At: PubMed
  • Published on 12/2/2025

    Lai M, Kim K, Zheng Y, Castellani CA, Ratliff SM, Wang M, Liu X, Haessler J, Huan T, Bonsu K, Newcomb C, McKessy K, Bielak LF, Zhao W, Joehanes R, Ma J, Guo X, Manson JE, Grove ML, Bressler J, Taylor KD, Lappalainen T, Kasela S, Blackwell TW, Lake NJ, Faul JD, Ferrier KR, Ekker SC, Hou L, Kooperberg C, Reiner AP, Zhang K, Peyser PA, Fornage M, Boerwinkle E, Raffield LM, Carson AP, Rich SS, Liu Y, Levy D, Rotter JI, Smith JA, Arking DE, Liu C. Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy. Nat Commun. 2025 Dec 02; 16(1):10962. PMID: 41330919.

     Read At: PubMed
  • Published on 12/1/2025

    Lee S, Joehanes R, Huan T, Liu C, Levy D, Ma J. Proteomics networks linking diet to cardiometabolic risk factors: the Framingham Heart Study. Am J Clin Nutr. 2025 Dec 01; 101131. PMID: 41338326.

     Read At: PubMed
  • Published on 11/22/2025

    Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q, Demirkale CY, Heard-Costa NL, Orchard P, Carson AP, Haessler JW, Raffield LM, Reiner AP, Franceschini N, Auer PL, Kooperberg C, Li Y, O'Connor G, Murabito JM, Munson P, Levy D. Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation. Nat Commun. 2025 Nov 22; 16(1):10615. PMID: 41274869.

     Read At: PubMed
  • Published on 10/24/2025

    Wang M, Zheng Y, Lai M, Saake E, Liu X, Guo X, Taylor KD, Huan T, Joehanes R, Nannini DR, Zhang K, Lake NJ, Castellani CA, Rich SS, Rotter JI, Liu Y, Raffield LM, Carson AP, Fornage M, Ma J, Arking DE, Hou L, Levy D, Liu C. Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases. Aging Cell. 2025 Dec; 24(12):e70279. PMID: 41132105.

     Read At: PubMed
  • Published on 10/10/2025

    Zhang Y, Rong J, Wang X, Schramm E, Pathiravasan CH, Borrelli B, Faro JM, Benjamin EJ, Trinquart L, Liu C, Murabito JM. Smartphone App-Based Survey Deployment Patterns and Longitudinal Response Rate: Randomized Controlled Trial. J Med Internet Res. 2025 Oct 10; 27:e73972. PMID: 41071587.

     Read At: PubMed
  • Published on 10/2/2025

    Rotti L, Murabito JM, Chen J, Cao Y, Ragab AAY, Liu C, Wang M, Doyle MF, Lunetta KL. Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort. Geroscience. 2025 Oct 02. PMID: 41039184.

     Read At: PubMed
  • Published on 7/21/2025

    Li Z, Ding H, Wang M, Li Y, Ang TFA, Ashita G, Gifford KA, Karjadi C, Levy D, Au R, Liu C. Association of DNA methylation age acceleration with digital clock drawing test performance: the Framingham Heart Study. Aging (Albany NY). 2025 Jul 21; 17(7):1721-1745. PMID: 40699219.

     Read At: PubMed
  • Published on 7/14/2025

    Carbonneau M, Li Y, Qu Y, Zheng Y, Wood AC, Wang M, Liu C, Huan T, Joehanes R, Guo X, Yao J, Taylor KD, Tracy RP, Durda P, Liu Y, Johnson WC, Post WS, Blackwell T, Rotter JI, Rich SS, Redline S, Fornage M, Wang J, Ning H, Hou L, Lloyd-Jones D, Ferrier K, Min YI, Carson AP, Raffield LM, Teumer A, Grabe HJ, Völzke H, Nauck M, Dörr M, Domingo-Relloso A, Fretts A, Tellez-Plaza M, Cole SA, Navas-Acien A, Wang M, Murabito JM, Heard-Costa NL, Prescott B, Xanthakis V, Mozaffarian D, Levy D, Ma J. DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases. Circulation. 2025 Aug 19; 152(7):436-449. PMID: 40654086.

     Read At: PubMed
  • Published on 6/3/2025

    Wang X, Zhang Y, Pathiravasan CH, Spartano NL, Benjamin EJ, McManus DD, Lewis GD, Larson MG, Vasan RS, Murabito JM, Liu C, Nayor M. Blood Pressure Responses During Exercise Were Associated With Average Home Blood Pressure and Home Blood Pressure Variability: The Electronic Framingham Heart Study. J Am Heart Assoc. 2025 Jun 03; 14(11):e039457. PMID: 40459124.

     Read At: PubMed

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