Josee Dupuis, PhD

Professor, Biostatistics
Josee Dupuis
(617) 638-5880dupuis@bu.edu
Crosstown Center – CT321

Biography

Josée Dupuis, Ph.D, is a Professor and Associate Chair of Biostatistics at Boston University School of Public Health. She previously held a faculty position at Northwestern University and more recently she was a senior statistical geneticist at Genome Therapeutics Corporation, a small biotech company. She has extensive experience in the development and application of methods for mapping complex traits. Her methodological work has included genome-wide significance level, mapping of quantitative traits in experimental organisms and robust quantitative trait linkage and association analysis methods in extended pedigrees. Her recent work involves the development of rare variant association tests in families, and approaches to detect gene x gene and gene x environment interactions. She is involved in the Framingham Heart Study, collaborating on projects to identify genes influencing diabetes related traits, pulmonary function and biomarkers of inflammation. She is a co-instructor for BS858 (Introduction to Statistical Genetics) in the Fall, and teaches BS860 (Statistical Genetics II) in the spring semester of even years.

Other Positions:

  • Associate Chair of Biostatistics, Biostatistics, Boston University School of Public Health
  • Member, Bioinformatics Graduate Program, Boston University

Education

  • Stanford University, PhD
  • Stanford University, MS
  • Concordia University , BS

Classes Taught

  • SPHBS715
  • SPHBS858
  • SPHBS860

Publications

  • Published on 5/7/2014

    Lin H, Yin X, Lunetta KL, Dupuis J, McManus DD, Lubitz SA, Magnani JW, Joehanes R, Munson PJ, Larson MG, Levy D, Ellinor PT, Benjamin EJ. Whole blood gene expression and atrial fibrillation: the framingham heart study. PLoS One. 2014; 9(5):e96794.

    Read at: PubMed
  • Published on 3/19/2014

    Ellis J, Lange EM, Li J, Dupuis J, Baumert J, Walston JD, Keating BJ, Durda P, Fox ER, Palmer CD, Meng YA, Young T, Farlow DN, Schnabel RB, Marzi CS, Larkin E, Martin LW, Bis JC, Auer P, Ramachandran VS, Gabriel SB, Willis MS, Pankow JS, Papanicolaou GJ, Rotter JI, Ballantyne CM, Gross MD, Lettre G, Wilson JG, Peters U, Koenig W, Tracy RP, Redline S, Reiner AP, Benjamin EJ, Lange LA. Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans. Hum Genet. 2014 Aug; 133(8):985-95.

    Read at: PubMed
  • Published on 2/15/2014

    Manichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, Budoff M, Austin JH, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJ, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O''Connor GT, Boezen HM, Rich SS, Barr RG. Genome-Wide Study of Percent Emphysema on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014 Feb 15; 189(4):408-18.

    Read at: PubMed
  • Published on 2/11/2014

    Vassy JL, Hivert MF, Porneala B, Dauriz M, Florez JC, Dupuis J, Siscovick DS, Fornage M, Rasmussen-Torvik LJ, Bouchard C, Meigs JB. Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes. 2014 Jun; 63(6):2172-82.

    Read at: PubMed
  • Published on 1/26/2014

    Chen H, Lumley T, Brody J, Heard-Costa NL, Fox CS, Cupples LA, Dupuis J. Sequence kernel association test for survival traits. Genet Epidemiol. 2014 Apr; 38(3):191-7.

    Read at: PubMed
  • Published on 12/2/2013

    Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert MF, Benazzo A, Rybin D, Jackson AU, Stringham HM, Song C, Fischer-Rosinsky A, Boesgaard TW, Grarup N, Abbasi FA, Assimes TL, Hao K, Yang X, Lecoeur C, Barroso I, Bonnycastle LL, Böttcher Y, Bumpstead S, Chines PS, Erdos MR, Graessler J, Kovacs P, Morken MA, Narisu N, Payne F, Stancakova A, Swift AJ, Tönjes A, Bornstein SR, Cauchi S, Froguel P, Meyre D, Schwarz PE, Häring HU, Smith U, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Quertemous T, Lind L, Hansen T, Pedersen O, Walker M, Pfeiffer AF, Spranger J, Stumvoll M, Meigs JB, Wareham NJ, Kuusisto J, Laakso M, Langenberg C, Dupuis J, Watanabe RM, Florez JC, Ingelsson E, McCarthy MI, Prokopenko I. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 2014 Jun; 63(6):2158-71.

    Read at: PubMed
  • Published on 7/10/2013

    Hendricks AE, Dupuis J, Logue MW, Myers RH, Lunetta KL. Correction for multiple testing in a gene region. Eur J Hum Genet. 2014 Mar; 22(3):414-8.

    Read at: PubMed
  • Published on 7/8/2013

    Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M, el Bouazzaoui F, Collins FS, Dunn SH, Dupuis J, Forouhi NG, Gillson C, Hattersley AT, Hong J, Kähönen M, Kuusisto J, Kedenko L, Kronenberg F, Doria A, Assimes TL, Ferrannini E, Hansen T, Hao K, Häring H, Knowles JW, Lindgren CM, Nolan JJ, Paananen J, Pedersen O, Quertermous T, Smith U. Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes. 2013 Oct; 62(10):3589-98.

    Read at: PubMed
  • Published on 5/21/2013

    Hunninghake GM, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle JC, Nishino M, Araki T, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Murphy E, Steele MP, Loyd JE, Schwarz MI, Fingerlin TE, Rosas IO, Washko GR, O'Connor GT, Schwartz DA. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013 Jun 6; 368(23):2192-200.

    Read at: PubMed
  • Published on 5/1/2013

    de Miguel-Yanes JM, Porneala B, Pencina MJ, Fox CS, Florez JC, Siscovick DS, Dupuis J, Meigs JB. Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study. J Hypertens. 2013 May; 31(5):1001-9.

    Read at: PubMed

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