Ana Fiszbein

Ana Fiszbein is an Assistant Professor of Biology at the College of Arts & Sciences and a Junior Faculty Fellow of the Hariri Institute at Boston University.  Her research seeks is to understand how gene architecture orchestrates the dynamic regulation of gene expression in normal cells and disease. Fiszbein’s work aims to build new computational tools to predict gene regulatory programs from genome sequences and gene architecture and design new strategies to manipulate gene expression with therapeutical purposes. Her lab uses a combination of high-throughput, functional genomics, bioinformatics and molecular approaches to study the co-transcriptional gene regulation of mammalian expression programs.

Fiszbein received her PhD in 2016 in Alberto Kornblihtt’s Lab at the University of Buenos Aires working at the intersection of transcription dynamics and RNA processing events. Her findings highlighted the importance of co-transcriptional RNA-processing in the nervous system, and spurred her interest in understanding additional modes of gene regulation. Ana then trained as a PEW postdoctoral fellow in Christopher Burge’s Lab at MIT where she discovered the Exon-Mediated Activation of Transcription Starts (EMATS) phenomenon in which the splicing of internal exons controls the spectrum of promoters used and the expression levels of the host gene. In January 2021, Ana started her lab at the Biology Department of Boston University and became a faculty member of the bioinformatic graduate program. 

Research Interests: Gene regulation; Transcription, RNA processing; co-transcriptional networks; computational genomics; cancer therapies

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