• Title Assistant Professor of Biology
  • Education PhD, University of Buenos Aires
  • Web Address https://www.fiszbeinlab.com/
  • Area of Interest Gene regulation; RNA processing; systems biology of co-transcriptional programs; computational genomics; role of gene architecture in cancer development and therapy
  • CV

Current Research

Our lab uses a combination of high-throughput, functional genomics, bioinformatics and molecular approaches to study the co-transcriptional gene regulation of mammalian expression programs.
The architecture of mammalian genes enables the production of multiple transcripts by using alternative promoters, alternative termination sites, and differentially spliced exons, which greatly expand the coding capacity of our genomes. Understanding how alternative RNA-processing events influence gene expression is of particular importance in cancer genomics, as their aberrant regulation contributes to the ~10 million cancer-related deaths each year.
Several effects of transcription on splicing have been established, and functional feedback from splicing to transcription has started to emerge. We recently characterized the phenomenon of Exon-Mediated Activation of Transcription Starts (EMATS), in which the splicing of internal exons impacts the spectrum of promoters used and expression levels of the host gene. However, a global understanding of the impacts of gene architecture and RNA-processing events in gene regulation is lacking, and the consequence in cells remains to be elucidated.

Our goal is to understand how gene architecture orchestrates the dynamic regulation of gene expression in normal cells and disease. We aim to build new computational tools to predict gene regulatory programs from genome sequences and gene architecture and design new strategies to manipulate gene expression with therapeutical purposes. We currently seek to understand three key aspects of gene regulation: (i) how promoter sequences drive RNA processing decisions, (ii) how transcription interferes with expression from nearby promoters, and (iii) how transcript starts and transcript ends are connected.

We are recruiting undergrads, grad students and postdocs. Get in touch!

Selected Publications

  • Fiszbein A, Krick KS, Begg BE, Burge CB (2019) Exon-mediated activation of transcription starts. Cell, 79 (7): 1551-1565.
  • Berardino BG, Chertoff M, Gianatiempo O, Alberca CD, Priegue R, Fiszbein A, Long P, Corfas G, Cánepa ET (2019) Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology. Neuroscience 408: 30178-2.
  • Zalcman G, Federman N, Fiszbein A, de la Fuente V, Ameneiro L, Schor IE, Romano A (2019) Sustained CaMKII delta gene expression is specifically required for long-lasting memories in mice. Mol Neurobiol 56 (2): 1437-1450.
  • Fiszbein A, Kornblihtt AR (2017) Alternative splicing switches: Important players in cell differentiation. BioEssays 39 (6): 1600157.
  • Fiszbein A, Kornblihtt AR (2016) Histone methylation, alternative splicing and neuronal differentiation. Neurogenesis 3: 2326-2133.
  • Fiszbein A, Giono LE, Quaglino A, Berardino BG, Singaut L, von Bildering C, Schor IE, Steinberg JHE, Rossi M, Pietrasanta LI, Caramelo JJ, Srebrow A, Kornblihtt AR (2016) Alternative splicing of G9a regulates neuronal differentiation. Cell Reports 14: 2797–2808. Featured on the cover.
  • Schor IE, Fiszbein A, Petrillo E, Kornblihtt AR (2013) Intragenic epigenetic changes modulate NCAM alternative splicing upon neuronal differentiation. EMBO Journal (14) 32: 2264-74.
  • Fiszbein A, Cánepa M, Vázquez GR, Maggese C, Pandolfi M (2010) Photoperiodic modulation of reproductive physiology and behavior in the cichlid fish Cichlasoma dimerus. Physiology and Behaviour (30)99: 425-32.
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