Biological systems are incredibly complex. Gaining predictive understanding of their function will enable solutions to grand challenges in medicine, energy, and the environment. Much of our understanding of biological systems comes from the study of their individual “parts”, yet we have relatively poor understanding of how these parts are organized and assemble to enable the remarkable functions of cells, tissues, organisms, and ecosystems. BU faculty are applying the complementary approaches of systems and synthetic biology to investigate, understand, and exploit the design principles of complex biological systems. In systems biology, we are developing pioneering genomic technologies to map molecular networks in cells with high-resolution, and building computational models to predict their physiological and disease-related behaviors. BU faculty are also advancing the emerging discipline of synthetic biology, which offers a powerful, bottom-up approach to investigate and rewire these systems. We are developing methods to rationally design and evolve biological circuits, creating fundamentally new systems not found in nature, and using them to reprogram cellular behavior. Our efforts are paving the way for a new foundation of cell-based devices, diagnostics, and therapies that will provide transformative ways to combat complex diseases.
Systems and Synthetic Bioengineering Faculty
Primary Faculty: Christopher Chen, Charles Delisi, Mary Dunlop, James Galagan, Alexander Green, Xue Han, Simon Kasif, Ahmad (Mo) Khalil, John Ngo, Allyson Sgro, Wilson Wong, Muhammad Zaman
Research Faculty: Dmitri Beglov, Jeroen Eyckmans, Dima Kozakov
Affiliated Faculty: Douglas Densmore, Pankaj Mehta, Daniel Segrè
Emeritus: Charles Cantor, Temple F. Smith, Maxim Frank-Kamenetskii
Affiliated Research Centers
- Biological Design Center (BDC)
- NSF Engineering Research Center in Cellular Metamaterials (Cell-MET)
- Biomolecular Engineering Research Center (BMERC)
- Nanotechnology Innovation Center (BUnano)
- Rajen Kilachand Center for Integrated Life Sciences & Engineering
- Rafik B. Hariri Institute for Computing and Computational Science & Engineering
BME Systems and Synthetic Bioengineering in the news:
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June 29, 2022
Schmidt Award Will Empower Khalil to Pursue Cross-Disciplinary Research
Associate Professor Ahmad “Mo” Khalil (BME) has earned the Schmidt Science Polymaths Award, recognizing him as a bold researcher and fueling the possibility of advances toward the engineering of new multicellular systems, including plants, that can help humanity address devastating diseases and grapple with climate change. Granting Khalil and his lab... [ More ]
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May 17, 2022
Biotech Developing “Tissue Therapeutics” to Treat Diseased Organs Launches from BU and MIT Labs
Satellite Bio, a regenerative medicine company cofounded by College of Engineering’s Christopher Chen, has received $110 million in funding By Andrew Thurston Greater Boston has become the nation’s biotech hub—the Silicon Valley of life sciences, according to some—and Massachusetts is now reportedly home to more than 1,000 biotech companies, employing more than... [ More ]
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March 18, 2022
A Simple Test for Viral Detection
Nature Biomedical Engineering has published Assistant Prof. Alex Green’s development of a new test that uses strands of RNA to return a test result. [...] [ More ]
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February 23, 2022
Green Garners Award to Develop Cell-Signal Sensor
Assistant Professor Alexander Green (BME) and a colleague at Yale University have earned a Scialog Collaborative Innovation Award to develop a new type of sensor capable of detecting heretofore hidden signals within a cell, with potential applications both diagnostic and therapeutic. In the dense chemical machinery of the cell, certain proteins... [ More ]
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February 18, 2022
Trio Tapped to Join AIMBE College of Fellows
Prestigious honor for top biomedical engineers For the second year in a row, three ENG faculty members have been elected to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE). This time, the honorees are Professor James Galagan (BME, Microbiology), Associate Professor Xue Han (BME), and... [ More ]
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February 9, 2022
Newly Named Allen Distinguished Investigators Aim to Recreate Lungs
The Paul G. Allen Family Foundation has awarded funding to a trio of BU faculty for a bold, early-stage project aimed at lab-grown lungs that mimic the real organ in all its fractal complexity. The proposal of Associate Professor Wilson Wong (BME), Professor Christopher Chen (BME, MSE), and School of... [ More ]
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November 18, 2021
Cross-disciplinary research teams win Kilachand funding
Five Studies Pushing the Limits of Science: This year’s Kilachand fund awards will support pioneering research across engineering and life sciences [ More ]
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June 1, 2021
Professor Ji-Xin Cheng and Coworkers Published in Nature Communications
By Caroline Amato BU researchers reported an ultrafast fingerprint-stimulated Raman spectroscopic imaging platform, with broad applications to cancer metabolism, brain mapping, and biofuel production, in Nature Communications on May 24th, 2021. This work was funded by grants from the Department of Energy and the NIH. ECE Professors Ji-Xin Cheng and Lei Tian... [ More ]
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May 26, 2021
3 BME Professors Elected to IAMBE
Congratulations to BU BME Professors Chris Chen, Joyce Wong and Mark Grinstaff on being elected 2021 Fellows of The International Academy of Medical and Biological Engineering. [ More ]
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March 26, 2021
One Small Step For A Mouse: Using Information Science to Understand the Brain
by Allison Kleber How does learning a new skill or process change the physical structure of the brain? Using techniques from data science and high-dimensional statistics, Professors Bobak Nazer (ECE), Venkatesh Saligrama (ECE, SE), and Xue Han (BME), aim to find out. Their project, titled “Discovering Changes in Networks: Fundamental Limits, [ More ]