Gina Peloso
Profiles

Gina Marie Peloso, PhD

Associate Professor, Biostatistics - Boston University School of Public Health

(617) 358-4466
gpeloso@bu.edu
Crosstown Center - 317
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Biography

Gina Peloso, PhD, is an Associate Professor in the Department of Biostatistics. Prior to joining BU, she was a post-doctoral fellow in Human Genetics at Massachusetts General Hospital and the Broad Institute. Her primary research focus is statistical genetics. She has contributed to the identification of common genetic variants through genome-wide association studies (GWAS) with complex cardiovascular traits, particularly with plasma lipid levels. She also investigates the role of rare genetic variation using both exome and whole genome sequencing. Her goals for studying genetic variation of blood lipid levels include, first, making insights into the biology behind the traits: What are the underlying causes of high/low lipid levels? Second, to use genetic variants to answer clinically meaningful questions: Can we use genetic variants to predict risk?: Does genetics point to potential therapeutic targets? Finally, to make connections between diseases by shared genetic contributions: What is the relationship between the genetics of blood lipid levels and Alzheimer’s disease (AD)? Gina is an active member in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and TOPMed Program, and a lead investigator in the Global Lipid Genetic Consortium (http://www.lipidgenetics.org/).

Other Positions

  • Investigator - Framingham Heart Study
  • Member, Genome Science Institute - Boston University

Education

  • Boston University, PhD Field of Study: Biostatistics
  • Boston University, MA Field of Study: Biostatistics
  • Boston University, BA Field of Study: Biology

Websites

Classes Taught

  • SPHBS852
  • SPHBS858
  • SPHBS943

Publications

  • Published on 9/9/2025

    Selvaraj MS, Li X, Li Z, Van Buren E, Haidermota S, Postupaka D, Hornsby W, Bis JC, Brody JA, Cade BE, Chung RH, Curran JE, Damrauer SM, de Las Fuentes L, de Vries PS, Duggirala R, Freedman BI, Graff M, Guo X, Hidalgo BA, Hou L, Irvin R, Judy R, Kalyani RR, Kelly TN, Konigsberg IR, Kral BG, Kwee LC, Levy D, Li C, Manichaikul AW, Martin LW, Montasser ME, Morrison AC, Naseri T, North KE, O'Connell JR, Palmer ND, Peyser PA, Reiner AP, Shah SH, Smit RAJ, Smith JA, Taylor KD, Tiwari H, Tsai MY, Viali S, Wang Z, Wang Y, Zhao W, Arnett DK, Blangero J, Boerwinkle E, Bowden DW, Carlson JC, Chen YI, Ellinor PT, Fornage M, He J, Heard-Costa N, Kaplan RC, Kardia SLR, Kooperberg C, Kraus WE, Lange LA, Loos RJF, Mitchell BD, Psaty BM, Rader DJ, Redline S, Rich SS, Yanek LR, Gibbs R, Gabriel S, Viaud-Martinez KA, Dutcher SK, Germer S, Kim R, Rotter JI, Lin X, Peloso GM, Natarajan P. Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals. Genome Biol. 2025 Sep 09; 26(1):273. PMID: 40926209.

     Read At: PubMed
  • Published on 8/29/2025

    Mohammadnia N, Xue L, Vestjens LTW, Uddin MM, Niroula A, de Kleijn DPV, Mosterd A, Fiolet ATL, Nakao T, Eikelboom JW, Cetinyurek-Yavuz A, Peloso GM, Bax WA, Riksen NP, Natarajan P, Cornel JH, El Messaoudi S, Honigberg MC. Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial. J Am Coll Cardiol. 2025 Aug 29. PMID: 40892620.

     Read At: PubMed
  • Published on 7/3/2025

    Lioutas VA, Peloso G, Romero JR, Aparicio H, Gonzales M, Werry A, Himali D, Himali J, Banerjee A, Gosh S, Ramachandran VS, Beiser A, Seshadri S. Long-Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study. J Am Heart Assoc. 2025 Jul 15; 14(14):e037817. PMID: 40611491.

     Read At: PubMed
  • Published on 7/3/2025

    Bhattacharya R, Marnell CS, Cho SMJ, Patel AP, Ruan Y, Koyama S, Jowell AR, Trinder M, Haidermota S, Lannery K, Honigberg MC, Zekevat SM, Surakka I, Peloso GM, Natarajan P. Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD. Circ Genom Precis Med. 2025 Aug; 18(4):e004937. PMID: 40605734.

     Read At: PubMed
  • Published on 7/3/2025

    Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. Front Syst Biol. 2025; 5. PMID: 40766210.

     Read At: PubMed
  • Published on 4/25/2025

    Shankar A, Truong B, Koyama S, Paruchuri K, Patel A, Peloso GM, Hornsby W, Natarajan P. Genotype-Phenotype Low-Density Lipoprotein Cholesterol Discordance and Coronary Artery Disease Risk. JACC Adv. 2025 May; 4(5):101677. PMID: 40286383.

     Read At: PubMed
  • Published on 4/2/2025

    Hu Y, Haessler J, Lundin JI, Darst BF, Whitsel EA, Grove M, Guan W, Xia R, Szeto M, Raffield LM, Ratliff S, Wang Y, Wang X, Fohner AE, Lynch MT, Patel YM, Lani Park S, Xu H, Mitchell BD, Bis JC, Sotoodehnia N, Brody JA, Psaty BM, Peloso GM, Tsai MY, Rich SS, Rotter JI, Smith JA, Kardia SLR, Reiner AP, Lange L, Fornage M, Pankow JS, Graff M, North KE, Kooperberg C, Peters U. Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants. Clin Epigenetics. 2025 Apr 02; 17(1):54. PMID: 40176173.

     Read At: PubMed
  • Published on 3/26/2025

    Yaqub A, Bis JC, Frenzel S, Koini M, Mbangdadji D, Peloso GM, Talluri R, Alonso A, Bahls M, Bülow R, Dörr M, Felix S, Fohner A, Friedrich N, Hofer E, Kavousi M, Launer LJ, Le T, Longstreth W, Mosley TH, Vernooij MW, Völzke H, Wittfeld K, Beiser AS, Grabe HJ, Gudnason V, Ikram MA, Psaty BM, Schmidt R, Simino J, Seshadri S, Wolters FJ. Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies. Neurology. 2025 Apr 22; 104(8):e213421. PMID: 40138616.

     Read At: PubMed
  • Published on 3/14/2025

    Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, Seshadri S, Goate AM, DeStefano AL, Peloso GM. Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project. J Alzheimers Dis. 2025 Apr; 104(3):841-851. PMID: 40084664.

     Read At: PubMed
  • Published on 2/7/2025

    Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Nat Comput Sci. 2025 Feb; 5(2):125-143. PMID: 39920506.

     Read At: PubMed

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