CDS Quantitative Biology Seminar Series Fall 2025

Speaker: Dr. Xiuwei Zhang, Assistant Professor and J. Z. Liang Early Career Assistant Professor in the School of Computational Science and Engineering at the Georgia Institute of Technology

Talk Title: "Studying single cells through multi-condition and spatial context"

Abstract: With the advances in single cell technologies, cells are profiled through multiple modalities, and data on samples from an increasing number of individuals are obtained. I will present our method, scDisInFact, that disentangles variation in multi-batch multi-condition scRNA-seq datasets, and predicts data under unseen conditions. I will also present methods developed in our group on spatial transcriptomics (ST) data, including SpaDecoder, that performs cell type deconvolution for spot-based ST data, and TemSOMap, that integrates spatial and scRNA-seq data by considering both spatial and temporal information of cells. Finally, I will present scMultiSim, which can be used to evaluate methods for multi-omics and spatial data.