M. Selim Ünlü, Ph.D.
Professor, Biomedical Engineering
Professor, Electrical and Computer Engineering
M.S. & Ph.D., University of Illinois, Urbana-Champaign
B.S., Middle East Technical University, Ankara, Turkey
Research in Optical Characterization and Nanophotonics (OCN) laboratory focuses on developing and applying advanced optical characterization techniques to the study of solid-state and biological phenomena at the nanoscale. Nanophotonics addresses a broad spectrum of optics on the nanometer scale covering technology and basic science. Compared to the behavior of isolated molecules or bulk materials; the behavior of nanostructures exhibit important physical properties not necessarily predictable from observations of either individual constituents or large ensembles.
Current projects include development of high-resolution subsurface imaging techniques based on numerical aperture increasing lens (NAIL) for the study of semiconductor devices and circuits and spectroscopy of quantum dots; optical characterization of carbon nanotubes; biosensors based on microring resonators; and development of new nanoscale microscopy techniques utilizing interference of excitation as well as emission from fluorescent molecules. In addition to microscopy, optical resonance is nearly ubiquitous in our research projects including development of resonant cavity enhanced photodetectors and imaging biosensors for DNA and protein arrays.
Selected Recent Publications
A. Yurt, G. G. Daaboul, J. H. Connor, B. B. Goldberg, and M. S. Ünlü. “Single nanoparticle detectors for biological applications” Nanoscale. (3 January 2012)
M. R. Monroe, A. Reddington, A. D. Collins, C. D. Laboda, M. Cretich, M. Chiari, F. F. Little, and M. S. Ünlü. “Multiplexed method to calibrate and quantitate fluorescence signal for allergen-specific IgE” Analytical Chemistry. (November 2011)
A. Abdo, M. Sahin, D. S. Freedman, E. Cevik, P. S. Spuhler, and M. S. Ünlü. “Floating light-activated microelectrical stimulators tested in the rat spinal cord” Journal of Neural Engineering. Vol. 8, No. 5. (October 2011)
C. Pereira, A. Yalcin, M. Cretich, M. Chiari, M. S. Ünlü, D. Nunes, and D. A. Bergstein. “Synergetic Chemiluminescence and Label-Free Dual Detection for Developing a Hepatitis Protein Array” Journal of Immunological Methods. Vol. 371: No. 1-2, pp. 159-164. (31 August 2011)
G. G. Daaboul, R. S. Vedula, S. Ahn, C. A. Lopez, A. Reddington, E. Ozkumur, and M. S. Ünlü. “LED-based Interferometric Reflectance Imaging Sensor for quantitative dynamic monitoring of biomolecular interactions” Biosensors and Bioelectronics. Vol. 26: pp. 2221-2227. (January 2011)
C. A. Lopez, G. G. Daaboul, R. S. Vedula, E. Ozkumur, D. A. Bergstein, T. W. Geisbert, H. Fawcett, B. B. Goldberg, J. H. Connor, and M. S. Ünlü. “Label-free multiplexed virus detection using spectral reflectance imaging” Biosensors and Bioelectronics. (2011)
G. G. Daaboul, A. Yurt, X. Zhang, G. M. Hwang, B. B. Goldberg, and M. S. Ünlü. “High-Throughput Detection and Sizing of Individual Low-Index Nanoparticles and Viruses for Pathogen Identification” Nano Letters. Vol. 11: pp. 4727-4731. (October 2010)
P. S. Spuhler, J. Knezevic, A. Yalcin, Q. Bao, E. Pringsheim, P. Dröge, U. Rant, and M. S. Ünlü. “Platform for in situ real-time measurement of protein-induced conformational changes of DNA” Proceedings of the National Academy of Science. (4 Jan 2010)
C. Joo, E. Ozkumur, M. S. Ünlü, and J. F. de Boer. “Spectral-domain optical coherence phase microscopy for label-free multiplexed protein microarray assay” Biosensors and Bioelectronics. Vol. 25,2: 275-281. (15 Oct 2009)
E. Ozkumur, A. Yalcin, M. Cretich, C. Lopez, D. A. Bergstein, B. B. Goldberg, M. Chiari, and M. S. Ünlü. “Quantification of DNA and protein adsorption by optical phase shift” Biosensors and Bioelectronics. Vol. 25: 167-172. (Sept 2009)
M. Dogan, I. Aksun, A. K. Swan, B. B. Goldberg, and M. S. Ünlü. “Closed-form representations of field components of fluorescent emitters in layered media.” Journal of the Optical Society of America A. Vol. 26. No. 6: 1458-1466. (June 2009)
A. Yalcin, F. Damin, E. Ozkumur, G. di Carlo, B. B. Goldberg, M. Chiari, and M. S. Ünlü. “Direct Observation of Conformation of a Polymeric Coating with Implications in Microarray Applications” Analytical Chemistry. Vol. 81: 625-630 (2009)