Stefano Monti
Profiles

Stefano Monti, PhD

Associate Professor, Biostatistics - Boston University School of Public Health

(617) 414-7031
smonti@bu.edu
Crosstown Center
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Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Other Positions

  • Professor, Medicine - Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center - Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University
  • Member, Bioinformatics Graduate Program - Boston University
  • Member, Genome Science Institute - Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students) - Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • University of Pittsburgh, PhD Field of Study: Artificial Intelligence
  • University of Pittsburgh, MS Field of Study: Artificial Intelligence
  • University of Houston, MS Field of Study: Computer Science
  • Università degli Studi di Udine, BS Field of Study: Computer Science

Websites

Classes Taught

  • SPHBS831

Publications

  • Published on 3/27/2026

    Monti S, Lustgarten MS, Huang Z, Song Z, Li M, Ellis D, Tian Q, Ferrucci L, Rappaport N, Andersen SL, Perls TP, Sebastiani P. Metabolomic signatures of extreme old age: findings from the New England Centenarian Study. Geroscience. 2026 Mar 27. PMID: 41888502.

     Read At: PubMed
  • Published on 3/11/2026

    Kroehling L, Chen A, Spinella A, Reed E, Kukuruzinska M, Varelas X, Monti S. A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer. Commun Med (Lond). 2026 Mar 11; 6(1). PMID: 41813916.

     Read At: PubMed
  • Published on 2/21/2026

    Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WJ, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies. Geroscience. 2026 Feb 21. PMID: 41723297.

     Read At: PubMed
  • Published on 2/4/2026

    Chen A, Kroehling L, Ennis CS, Denis GV, Monti S. A highly resolved integrated single-cell atlas of human breast cancers. NAR Genom Bioinform. 2026 Mar; 8(1):lqaf217. PMID: 41640877.

     Read At: PubMed
  • Published on 1/16/2026

    Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2026 Jan 16; 86(2):503-518. PMID: 41066547.

     Read At: PubMed
  • Published on 11/29/2025

    Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT. A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E. Adv Sci (Weinh). 2026 Jan; 13(4):e09764. PMID: 41316897.

     Read At: PubMed
  • Published on 10/11/2025

    Dowrey TW, Cranston SF, Skvir NJ, Lok Y, Bock P, Kharitonova EK, MacDonald E, Zeldich E, Gabel CV, Tyshkovskiy A, Monti S, Gladyshev VN, Sebastiani P, Perls TT, Andersen S, Murphy GJ. IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures. bioRxiv. 2025 Oct 11. PMID: 41279005.

     Read At: PubMed
  • Published on 9/16/2025

    Monti S, Lustgarten MS, Huang Z, Song Z, Ellis D, Tian Q, Ferrucci L, Rappaport N, Andersen SL, Perls TP, Sebastiani P. METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY. bioRxiv. 2025 Sep 16. PMID: 41000658.

     Read At: PubMed
  • Published on 8/26/2025

    Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko NY, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. Commun Biol. 2025 Aug 26; 8(1):1276. PMID: 40858992.

     Read At: PubMed
  • Published on 7/18/2025

    Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WS, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies. bioRxiv. 2025 Jul 18. PMID: 40791342.

     Read At: PubMed

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