Stefano Monti
Profiles

Stefano Monti, PhD

Associate Professor, Biostatistics - Boston University School of Public Health

(617) 414-7031
smonti@bu.edu
Crosstown Center
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Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Other Positions

  • Professor, Medicine - Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center - Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research - Boston University
  • Member, Bioinformatics Graduate Program - Boston University
  • Member, Genome Science Institute - Boston University
  • Graduate Faculty (Primary Mentor of Grad Students) - Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • University of Pittsburgh, PhD Field of Study: Artificial Intelligence
  • University of Pittsburgh, MS Field of Study: Artificial Intelligence
  • University of Houston, MS Field of Study: Computer Science
  • Università degli Studi di Udine, BS Field of Study: Computer Science

Websites

Classes Taught

  • SPHBS831

Publications

  • Published on 10/9/2025

    Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2025 Oct 09. PMID: 41066547.

     Read At: PubMed
  • Published on 8/26/2025

    Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko NY, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. Commun Biol. 2025 Aug 26; 8(1):1276. PMID: 40858992.

     Read At: PubMed
  • Published on 7/18/2025

    Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WS, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies. bioRxiv. 2025 Jul 18. PMID: 40791342.

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  • Published on 7/9/2025

    Llévenes P, Chen A, Lawton M, Rondón-Ortiz AN, Qiu Y, Seen M, Monti S, Denis GV. Plasma exosomes in insulin resistant obesity exacerbate progression of triple negative breast cancer. BMC Cancer. 2025 Jul 09; 25(1):1089. PMID: 40629272.

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  • Published on 7/7/2025

    Li W, Nishino M, Reed E, Akshinthala D, Pasha HA, Anderson ES, Huang L, Hebestreit H, Monti S, Gomez ED, Jalisi SM, Muthuswamy SK. Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses. Sci Rep. 2025 Jul 07; 15(1):24221. PMID: 40624315.

     Read At: PubMed
  • Published on 7/3/2025

    Trepicchio C, Rauner G, Traugh N, Wang R, Parrish M, Fein DEC, Mal Y, Gupta PB, Monti S, Kuperwasser C. DDR1 regulates RUNX1-CBFß to control breast stem cell differentiation. Stem Cell Reports. 2025 Aug 12; 20(8):102576. PMID: 40614729.

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  • Published on 7/3/2025

    Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. Front Syst Biol. 2025; 5. PMID: 40766210.

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  • Published on 6/3/2025

    Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes. Mol Cancer Res. 2025 Jun 03; 23(6):567-578. PMID: 40047645.

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  • Published on 5/28/2025

    Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT. Robust Serum Proteomic Signatures of APOE2. bioRxiv. 2025 May 28. PMID: 40501769.

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  • Published on 5/20/2025

    Shastry A, Hiller BE, Sanders NL, Tseng AE, Kothari J, O'Connell AK, Gertje HP, Ha CT, Murzin E, Traber KE, Lederer JA, Jones MR, Douam F, Beach TG, Remick DG, Crossland NA, Monti S, Campbell JD, Mizgerd JP. Sub-phenotypes of pneumonia defined by pulmonary histopathological features. bioRxiv. 2025 May 20. PMID: 40475544.

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