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CAS CH 541: Natural Products Chemistry
Undergraduate Prerequisites: CASCH212 or CAS CH 214; or equivalent, or consent of instructor.
Chemical and biosynthetic pathways leading to important natural products derived from fatty acids, terpenes, amino acids, polyketides, shikimic acid, and other biosynthetic intermediates. Three hours lecture, one-hour discussion.
CAS CH 550: Materials Chemistry
Undergraduate Prerequisites: CAS CH 112 (or CH 110 or CH 102/201) and CAS CH 212 (or CH 214) and CAS PY 212; or consent of instructor.
Structure, synthesis, properties of hard and soft materials (alternate years) are covered.
GRS CH 621: Biochemistry I
Undergraduate Prerequisites: CAS CH 204 and CAS CH 212; or equivalent.
Introductory biochemistry. Protein structure and folding enzyme mechanisms, kinetics, and allostery; nucleic acid structure; macromolecular biosynthesis with emphasis on specificity and fidelity; lipids and membrane structure; bioenergetics; vitamins and coenzymes; introduction to intermediary metabolismvitamins and coenzymes; introduction to intermediary metabolism. Three hours lecture, four hours laboratory, one-hour discussion. Effective Fall 2020, this course fulfills a single unit in each of the following BU Hub areas: Writing-Intensive Course, Quantitative Reasoning II, Critical Thinking.
GRS CH 622: Biochemistry II
Graduate Prerequisites: GRS CH 621; or equivalent or consent of instructor.
Cellular metabolism, with special emphasis on the integration and regulation of catabolic, anabolic, and anaplerotic routes, and the generation and utilization of energy. Additional topics include the metabolism of intermediaries, lipids and isoprenoids, nitrogen compounds, and nucleotides. Effective Spring 2021, this course fulfills a single unit in each of the following BU Hub areas: Research and Information Literacy, Teamwork/Collaboration.
GRS CH 624: Macromolecular Structure Determination
Graduate Prerequisites: CH/BI 421; or equivalent, or consent of instructor
This course covers the determination of structures of biological macromolecules including RNA, DNA, and proteins. Topics include macromolecular assemblies and symmetry, crystal forms, diffraction, phase determination, data acquisition, model building and refinement, model analysis and homology modeling.
GRS CH 625: Enzymology: Mechanisms of Enzymatic Reactions
Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
Covers enzyme structure-function relationships. A tool-box of methods is presented, including kinetics (steady state and pre-steady state methods), isotope effects, stereo-chemical methods, site-directed mutagenesis, methods to replace natural with unnatural amino acids, mechanism based inhibitors.
GRS CH 628: Protein Chemistry
Graduate Prerequisites: GRS CH 621; or equivalent, or consent of instructor.
The structure and function of selected enzymes, motor/pump proteins, and structural protein assemblies, highlighting concepts in macromolecular structure analysis, including linking structure and dynamics to catalysis. Analysis of selected primary literature underscoring structural underpinnings via molecular graphics.
GRS CH 641: Physical Organic Chemistry
Undergraduate Prerequisites: CAS CH 352; or equivalent or consent of instructor.
Physical fundamentals of organic chemistry. Thermodynamics, kinetics, molecular orbital theory, and theory of concerted reactions. Isotope effects, aromaticity, linear free energy relationships, acidity functions, photo- and free-radical chemistry.
GRS CH 642: Organic Reaction Mechanisms
Graduate Prerequisites: CAS CH 212 and CAS CH 301; or equivalent, or consent of instructor.
Fundamentals of organic reaction mechanisms related to acid/base catalysis, reactions of the carbonyl group, cycloadditions, nucleophilic displacement reactions, and redox chemistry.
GRS CH 643: Synthetic Methods of Organic Chemistry
Graduate Prerequisites: GRS CH 642.
Organic synthesis strategies for total synthesis of complex natural products. Various approaches for organic molecules whose synthesis constitutes major contributions to organic chemistry.
GRS CH 646: Organic Spectroscopy and Structure Determination
Graduate Prerequisites: CAS CH 212 and CAS CH 351; or equivalent, or consent of instructor.
Spectroscopic methods in organic structure determination, including mass spectrometry with main emphasis on nuclear magnetic resonance.
GRS CH 647: The Chemistry of Biotechnology
Graduate Prerequisites: CAS CH 212 or CAS CH 214, CAS CH 301, CAS CH 422.
This course focuses on the application of chemical principles in different biotechnologies. With the importance of the biotechnology sector nationally and in Boston, this interdisciplinary course explores how the chemical sciences contribute to this growing area.
GRS CH 648: Contemporary Drug Discovery
Graduate Prerequisites: CAS CH 203/204, CH 203/214, or CH 211/212; or equivalent, or consent of the instructor.
This course is aimed at graduate and advanced undergraduate students who have an interest in drug discovery research. It covers the key theory and practice associated with the discovery and development of drugs and tool compounds. In focusing on the biochemical and pharmacological aspects of drug discovery, it complements GRS CH644 Medicinal Chemistry. Three hours lecture.
GRS CH 651: Molecular Quantum Mechanics I: Fundamentals
Undergraduate Prerequisites: CAS CH 351 and CAS CH 352; or equivalent.
Postulates and general formalism with emphasis on chemical applications; application to particle in a box, harmonic oscillator, hydrogen atom; tunneling; angular momentum theory, spin, spin-orbit coupling; ladder operators; time- independent perturbation theory, computational methods including tight-binding model and Huckel theory.
GRS CH 652: Molecular Quantum Mechanics II: Dynamics and Spectroscopy
Undergraduate Prerequisites: GRS CH 651; or equivalent.
Graduate Corequisites: GRS CH 654.
Time-dependent perturbation theory; potential surface; Born-Oppenheimer approximation/breakdown; radiation-matter interaction; line shapes; quantum density operator; quantum master equations; spin-boson model. Applications to absorption, Raman and CD spectroscopies; nonlinear and time domain spectroscopies including SHG, pump-probe, CARS, and photon echoes. Computational methods.
GRS CH 653: Molecular Quantum Mechanics III: Electronic Structure
Undergraduate Prerequisites: GRS CH 652; or equivalent.
Introduction to electronic structure theory and modern quantum chemistry software. Focus on theoretical foundations, capabilities, and limitations of wave-function- based and density functional theory methods. Relevant software tutorials and computational homework assignments. Skills to design and independently perform quantum chemical simulations.
GRS CH 654: Methods of Chemical Physics
Undergraduate Prerequisites: consent of instructor.
Graduate Prerequisites: consent of instructor.
Fundamentals and applications of theoretical methods in chemical physics. Vector calculus. Multipole expansion and normal modes. Fourier series and Fourier transforms. Laplace transforms. Functions of a complex variable. Green's function methods. Theory of linear vector spaces. Advanced matrix algebra. Eigenvalue problems.
GRS CH 655: Statistical Mechanics I
Undergraduate Prerequisites: GRS CH 651; or equivalent or consent of instructor.
Graduate Prerequisites: GRS CH 651; or equivalent or consent of instructor.
Basic concepts in statistics, thermodynamics, and quantum mechanics. Ensembles. Fermi-Dirac, Bose-Einstein, and Gibbs-Boltzmann statistics. Ideal gas, atomic crystals, Ising model, Langmuir isotherm, lattice statistics. Polyatomic molecules, polymers, and biomolecules. Polymer and polyelectrolyte solutions.
GRS CH 656: Statistical Mechanics II
Undergraduate Prerequisites: GRS CH 655; or equivalent or consent of instructor.
Topics in equilibrium and non-equilibrium statistical mechanics with chemical applications. Theories of gases and liquids, ionic solutions and interfaces, time correlation functions, linear response theory, Brownian motion, generalized Langevin equation, projection operator, rate theories, discrete kinetics, fluctuation theorem, phase transition.
GRS CH 677: An Introduction to Evidence-Based Undergraduate STEM Teaching
Online course with in-person faculty-led sessions. Participants learn about effective teaching strategies and the research that supports them, and apply approaches to lesson design and assignments for future teaching opportunities.