Chemistry

  • CAS CH 541: Natural Products Chemistry
    Undergraduate Prerequisites: CASCH212 or CAS CH 214; or equivalent, or consent of instructor.
    Chemical and biosynthetic pathways leading to important natural products derived from fatty acids, terpenes, amino acids, polyketides, shikimic acid, and other biosynthetic intermediates. Three hours lecture, one-hour discussion.
  • CAS CH 550: Materials Chemistry
    Undergraduate Prerequisites: CAS CH 112 (or CH 110 or CH 102/201) and CAS CH 212 (or CH 214) and CAS PY 212; or consent of instructor. In addition, CAS CH 232 is recommended, but not required.
    Basic chemistry and physical properties of hard or soft materials (alternate years). Topics include material structure, synthesis, and properties, with applications to materials such as fuel cells, super- and semiconductors, nanomaterials, and biomaterials. Connections between materials properties and applications, such as energy capture, conversion, and storage, are covered.
  • GRS CH 621: Biochemistry I
    Undergraduate Prerequisites: CAS CH 204 and CAS CH 212; or equivalent.
    Introductory biochemistry. Protein structure and folding enzyme mechanisms, kinetics, and allostery; nucleic acid structure; macromolecular biosynthesis with emphasis on specificity and fidelity; lipids and membrane structure; bioenergetics; vitamins and coenzymes; introduction to intermediary metabolismvitamins and coenzymes; introduction to intermediary metabolism. Three hours lecture, four hours laboratory, one-hour discussion. Effective Fall 2020, this course fulfills a single unit in each of the following BU Hub areas: Writing-Intensive Course, Quantitative Reasoning II, Critical Thinking.
    • Quantitative Reasoning II
    • Critical Thinking
    • Teamwork/Collaboration
    • Writing-Intensive Course
  • GRS CH 622: Biochemistry II
    Graduate Prerequisites: GRS CH 621; or equivalent or consent of instructor.
    Cell metabolism, including the regulation of catabolic, anabolic, and anaplerotic routes, and generation and utilization of energy in prokaryotic and eukaryotic organisms. Polysaccharides, energy storage; lipid and isoprene, nitrogen, and nucleotide metabolism; macromolecular biosynthesis of RNA, DNA, and protein. Three hours lecture, four hours laboratory, one-hour discussion.
  • GRS CH 623: Chemical Biology
    Undergraduate Prerequisites: GRS CH 621; (GRSCH622 recommended), or consent of instructor.
    Research at the chemistry-biology interface, including directed evolution, unnatural amino acid mutagenesis, chemical genetics, proteomics, and fluorescent reporters of enzyme function. Reading, discussing and evaluating the current chemical biology literature is a significant component of the course.
  • GRS CH 624: Macromolecular Structure Determination
    Graduate Prerequisites: CH/BI 421 or consent of instructor
    This course covers the determination of structures of biological macromolecules including RNA, DNA, and proteins. Topics include macromolecular assemblies and symmetry, crystal forms, diffraction, phase determination, data acquisition, model building and refinement, model analysis and homology modeling.
  • GRS CH 625: Enzymology: Mechanisms of Enzymatic Reactions
    Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Covers enzyme structure-function relationships. A tool-box of methods is presented, including kinetics (steady state and pre-steady state methods), isotope effects, stereo-chemical methods, site-directed mutagenesis, methods to replace natural with unnatural amino acids, mechanism based inhibitors.
  • GRS CH 626: Epigenetics
    Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Surveys protein post-translational modifications and DNA/RNA processing, including mechanistic enzymology of protein and DNA modifications, signal transduction induced by the modifications, and related practical applications.
  • GRS CH 627: RNA Structure and Function
    Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Chemical and structural biology of natural RNA molecules, including ribosomal RNA, catalytic RNA (ribozymes), siRNA (small interfering RNA), microRNA, long non-coding RNA, riboswitches, and CRISPR.
  • GRS CH 629: DNA Nanotechnology
    Graduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Structural biology of DNA. Synthetic DNA objects, DNA origami, DNA templated synthesis, and DNAzymes. The main focus is DNA in nanotechnology, not the involvement of DNA in cell and molecular biology.
  • GRS CH 631: Advanced Coordination Chemistry I: Structure and Bonding
    Undergraduate Prerequisites: CAS CH 232; or equivalent, or consent of instructor.
    The interdependence of chemical bonding, spectroscopic characteristics, and reactivity properties of coordination compounds and complexes are described and formalized using the fundamental concept of symmetry, as applied to inorganic coordination complexes.
  • GRS CH 632: Advanced Coordination Chemistry II: Inorganic Reaction Mechanisms
    Undergraduate Prerequisites: CAS CH 232 and CAS CH 214; or consent of instructor.
    The mechanistic study of ligand substitution and electron transfer processes in coordination compounds are discussed in the context of basic molecular orbital theory. The connections between small molecule inorganic and biological macromolecular metal-catalyzed processes are presented.
  • GRS CH 633: Physical Methods for Inorganic and Bioinorganic Chemistry
    Undergraduate Prerequisites: CAS CH 232 and CAS CH 352 or GRS CH 631; or equivalents, or consent of instructor.
    A discussion of the physical techniques for the study of structural, magnetic, and redox-active properties of transitional metal complexes. Techniques discussed include x-ray crystallography; x-ray absorption; vibrational, NMR, EPR, and Mossbauer spectroscopies; and electrochemistry.
  • GRS CH 634: Metallobiochemistry
    Undergraduate Prerequisites: CAS CH 232 and CAS CH 421; or equivalents, or consent of instructor.
    The roles of transition metals in biology are assessed by review of the structural, spectroscopic, and genetic aspects of metallobiochemistry. Metal import and trafficking; cofactor biogenesis; biocatalytic transformations in biochemistry; reactive oxygen species; the inorganic basis of life.
  • GRS CH 635: Synthetic Methodology in Inorganic Chemistry
    Graduate Prerequisites: CAS CH 232; or equivalent.
    The descriptive chemistries of the metallic elements are surveyed to develop a broad knowledge of these elements and how to prepare their compounds and understand the resultant reactivities. Case studies are taken from older and recent literature sources.
  • GRS CH 641: Physical Organic Chemistry
    Undergraduate Prerequisites: CAS CH 352 or GRS CH 651; CAS CH 352 or equivalent or GRS CH 651 or consent of instructor.
    Graduate Prerequisites: CAS CH 352; or equivalent or consent of instructor.
    Physical fundamentals of organic chemistry. Thermodynamics, kinetics, molecular orbital theory, and theory of concerted reactions. Isotope effects, aromaticity, linear free energy relationships, acidity functions, photo- and free-radical chemistry.
  • GRS CH 642: Organic Reaction Mechanisms
    Undergraduate Prerequisites: CAS CH 212 and CAS CH 301; or equivalent, or consent of instructor.
    Graduate Prerequisites: CAS CH 212; or consent of instructor.
    Fundamentals of organic reaction mechanisms related to acid/base catalysis, reactions of the carbonyl group, cycloadditions, nucleophilic displacement reactions, and redox chemistry.
  • GRS CH 643: Synthetic Methods of Organic Chemistry
    Undergraduate Prerequisites: GRS CH 642.
    Graduate Prerequisites: GRS CH 641 and GRS CH 642.
    Organic synthesis strategies for total synthesis of complex natural products. Various approaches for organic molecules whose synthesis constitutes major contributions to organic chemistry.
  • GRS CH 644: Medicinal Chemistry
    Graduate Prerequisites: strong background in organic chemistry.
    Synthetic organic chemistry and pharmacology as applied to development, testing, and production of medically useful agents. Lectures and discussions by research chemists affiliated with leading pharmaceutical companies. A research paper is required.
  • GRS CH 645: Transition Metal Chemistry
    Undergraduate Prerequisites: junior standing and CAS CH 203/204 (or CH 203/214 or CH 211/212) and CH 232; recommended corequisite: CH 301.
    Introduction to the concepts of transition metal-mediated reactions and mechanisms, including electronic structure and properties, reaction mechanisms, kinetics, organometallic compounds, catalytic reactions, and aspects of asymmetric catalysis.