Target Discovery Proteomics Laboratory

The BU Target Discovery and Proteomics Lab (BU-TDPL) was founded in 2021 by Professor John Porco with the aim of resolving a key bottleneck in drug discovery: inadequate target ID. To address this challenge, the TDPL has implemented innovative compound-protein interaction mapping technologies based on precision mass spectrometry that allow for systematic identification of the protein targets of bioactive leads from compound screens to characterize mode-of-action and structure-activity relationships. This laboratory is currently housed on the Charles River Campus (LSE 712) and is closely interfaced with the BU Center for Molecular Discovery on the Charles River Campus, and chemical/biological investigators on both the Charles River and Medical Campuses.