Limited Submission Opportunity: NIH Immune Tolerance Network (UM1 Clinical Trial Required)
NIH Immune Tolerance Network (UM1 Clinical Trial Required)
URL: https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-19-068.html
OBJECTIVES:
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Immune Tolerance Network. The major goal of this Network is to develop tolerogenic approaches for the treatment and prevention of disease in three clinical areas: asthma and allergic diseases; autoimmune diseases; and immune-mediated consequences of allotransplantation. The scope of research to be carried out includes: 1) the design and conduct of clinical trials at all phases to evaluate the safety and efficacy of investigational products and approaches for the induction and maintenance of immune tolerance in humans, 2) the design and conduct of mechanistic studies and the development of tolerance assays as integral components of the clinical trials undertaken, including establishing and directing a consortium of laboratories and one or more biospecimen repositories, and 3) the provision of bioinformatics, data collection, validation and analysis resources. In addition, on a limited basis, the Network may support focused product development and nonclinical studies (e.g., toxicology, pharmacology, pharmacokinetics, etc.) essential for the subsequent evaluation of promising tolerance induction approaches in humans.
FUNDING INFORMATION: $27,000,000 ($23,000,000 direct costs)
ELIGIBILITY RESTRICTIONS:
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
INTERNAL SELECTION PROCESS:
Interested investigators should submit the following materials via InfoReady Review by DATE:1/13/2020
- Questions outlined in InfoReady Review application;
- A letter of recommendation from the appropriate department chair or dean
- A brief statement (up to 2 pages) by the candidate describing their scientific achievements and proposed project including proposed leadership and potential network members/sites;
- A brief budget outline for the proposed project
- Up-to-date CV or biosketch.
A faculty committee drawn from both campuses will review internal proposals and select nominees.
DEADLINES:
Internal Materials Due: Monday, January 13, 2020
Sponsor Deadline:
LOI: Monday, February 3, 2020
Application: Tuesday, March 3, 2020