John Caradonna, PhD

Associate Professor (Chemistry, MSE)

Office 24 Cummington Mall
Email caradonn@bu.edu
Phone 617-353-1692
Website Caradonna Group Home Page

Publications

View a complete list of publications chronologically by year.
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Research Areas

The Caradonna research group is interested in understanding the mechanism of action of non-heme iron metalloproteins, with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions. Our efforts span the continuum from the investigation of small molecule synthetic complexes that catalyze oxygen atom transfer reactions, to the characterization of an interesting class of iron/pterin-dependent aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylases), to the computational design of functional metalloproteins (iron-sulfur-based electron transfer clusters, Fe and Mn superoxide dismutanse). A broad-based approach, including chemical, molecular biological, and biophysical (spectroscopic) techniques, is used to develop a global understanding of the intrinsic characteristics of the active site metal centers and the role played by the protein matrix in regulating, modulating, and tuning these properties.

Honors and Awards

Alfred P. Sloan Foundation Research Award, 1993-95
Member, American Association for the Advancement of Science, 1988
Camille and Henry Dreyfus Award for Distinguished Faculty in Chemistry, 1987
NIH Postdoctoral Fellowship, Harvard University, 1985 – 1987
Pegram Award, Columbia University, 1984
National Cancer Institute, 1980-82
Public Health National Research Service Award, 1980 – 1981
Member, American Chemical Society, 1979

Additional Affiliations

Division of Materials Science & Engineering

Department or Division: Materials Science & Engineering

Affiliation: Primary & Affiliated Faculty

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