Quantitative Biology

Options

Volunteer Basis, Potential for UROP Funding, Potential for Academic Credit

Overview

Remote computer-based research opportunities are available in the Marintchev lab. The projects require varying levels of computer skills. No prior biology knowledge is required; however, willingness to learn the main concepts is.

The opportunities are best suited for students looking for long-term research opportunities, with the goal of eventually being able to pursue an independent project.

Our research is focused on elucidating the molecular mechanisms and regulation of protein synthesis (translation) in human cells and the integrated stress response (ISR). Dysregulated ISR is a causative factor in Alzheimer’s Disease and other neurodegenerative disorders. Specific areas of interest include:
– The architecture of the translation initiation complexes, the molecular mechanisms of key steps in the process, and their regulation.
– The coordination between translation initiation and ISR and how ISR inhibitors can be used to protect neurons from apoptosis.

Projects:

1. Writing codes to assist with semi-automatic NMR backbone assignments – determining which peak in NMR spectra corresponds to which amino-acid in the protein.
Requires advanced coding skills. The biological concepts the students would need to learn are minimal.

2. Bioinformatics analysis of large datasets from high-throughput RNA sequencing experiments. Aimed at elucidating the mechanisms of protein synthesis regulation at a cellular level.
Requires advanced coding skills and willingness to learn the underlying biological concepts. Previous experience with bioinformatics preferred, but not required, especially for underclassmen.

3. Quantitative analysis (“accounting”) of the translation process in dividing vs. resting cells or under stress conditions. The project involves analysis of high-throughput proteomic data
Advanced coding skills are not required. Willingness to learn the underlying biological concepts is a must.

Students interested in summer research need to be able to commit to at least two months full-time (30-40 hours per week).

Students interested in research during the school year need to be able to commit to at least 10 hours a week on average. That means being able to work 15-20 hours on some weeks, because they will likely not be able to work at other times due to exams or other commitments.

Back to On-Campus Opportunities