Professor Trevor Siggers and his lab use the big-picture systems biology approach to research the functions of the inflammatory system to unlock the secrets of immune responses.
The goal of Siggers’ research is to discover which of the thousands of potential locations on the human genome the NF-kB and the HMGA1 proteins actually bind to. Armed with this information, drug developers would be able to create medications that stop the proteins from turning on those genes, and thus could fight inflammatory diseases without the harmful side effects of current medications. Learn more from the BU Research article, “Setting the Stage for Smarter Drugs.”