Assen Marintchev

Our research is focused on elucidating the molecular mechanisms and regulation of protein synthesis (translation) in human cells and the integrated stress response (ISR). Dysregulated ISR is a causative factor in Alzheimer’s Disease and other neurodegenerative disorders. Specific areas of interest include:

• the architecture of the translation initiation complexes;
• the coordination between translation initiation and ISR, and how ISR inhibitors can be used to protect neurons from apoptosis;
• and quantitative analysis of the translation process in dividing vs. resting cells or under stress conditions.