Biomedical research—mechanisms of disease

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Overview

The primary goal of our laboratory is to identify pathways that control extracellular matrix (ECM) synthesis and assembly as they relate to fibroproliferative and connective tissue diseases. Fibroproliferative responses are similar to wound healing processes involving accumulation of contractile myofibroblasts and ECM secretion and assembly. Because organ fibrosis, cardiovascular, metabolic/obesity, and cancer pathologies are now recognized to be regulated by fibroblast-myofibroblast differentiation and ECM remodeling our research is examining control mechanisms in these diseases. Central to our studies is determining the function of Aortic Carboxypeptidase-Like Protein (ACLP), a secreted, collagen-binding protein that enhances fibrosis and myofibroblast differentiation through mechanisms that involve stimulating the transforming growth factor β (TGFβ) receptor signaling complex and controlling mechanical signaling and ECM remodeling. Recent work is uncovering the role of ACLP and AEBP1 genetic mutations in Ehlers Danlos Syndrome and in aortic aneurysm.

We are particularly interested in recruiting undergraduates that can work with us on longer term projects including summer UROP.

Interested students should send an updated resume/CV and class schedule/availability to participate in research. Please note that our lab is located on the medical campus.

We have filled our undergrad positions for the fall 2024 semester. We would consider additional undergrads for the spring and summer UROP 2025.
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