Dr. Fredrick Ruberg and Dr. Omar Siddiqi discuss the general overview of ATTR treatment with new developments over the past year (APOLLO-B, ATTRibute-CM), currently enrolled trials (HELIOS-B, CARDIOTTRansform), and future trials (DepleTTR-CM, MAGNITUDE). They will also cover current heart failure therapy updates (SGLT2i) and imaging (evuzamitide).