Michael Alosco

Assistant Professor of Neurology

Education
PhD
Email
malosco@bu.edu

Background

Dr. Alosco is a licensed clinical neuropsychologist. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus on neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. Dr. Alosco completed his post-doctoral studies in neuropsychology via NIH-funded training Awards (T32, F32) at the Boston University Alzheimer’s Disease Research Center and CTE Center. In 2018, he became an Assistant Professor of Neurology at the Boston University School of Medicine and he was promoted to Associate Professor in 2019. Dr. Alosco has >140 peer-reviewed publications, is the recipient of an NIH/NINDS K23 Award, is the Project Lead of an NIH-funded multisite U54 grant, and serves as a PI and/or co-investigator on numerous federal and non-federal funded grants. He has also written numerous book chapters, and he is the co-Editor of the Oxford Handbook of Adult Cognitive Disorders which was published by Oxford University Press in 2019.

CTE Center Role

Dr. Alosco is a lead investigator of the BU CTE Center. He is the Project Lead of a multisite NIH/NINDS-funded U54 that is examining the late neuropathologies of exposure to repetitive head impacts and TBI and resulting clinical syndromes. He conducts clinical interviews with family members and other caregivers of deceased athletes who donate their brains to our Center. He oversees studies on risk factors and clinicopathological correlations of CTE and related dementias. Dr. Alosco additionally leads human subject studies devoted to biomarker development for CTE, including the Focused Imaging for the Neurodegenerative Disease-Chronic Traumatic Encephalopathy (FIND-CTE) study. FIND-CTE is a collaborative effort with the University of California, San Francisco (UCSF) that is evaluating the ability of PET imaging and other neuroimaging techniques to detect CTE and related pathologies during life.

ADC Role

Dr. Alosco is the Clinical Core Co-Leader of the NIA-funded BU ADRC. In this role, he assists with the oversight of all clinical core operations of the ADRC which includes annual neurological, neuropsychological, and MRI research exams of approximately 400 participants. Dr. Alosco has specific responsibilities for all operations related to the neuropsychological evaluations that are done as part of the BU ADRC. He participates in weekly multidisciplinary diagnostic consensus conferences to assist with the clinical diagnoses for participants enrolled in the ADRC Clinical Core. Dr. Alosco is also the Clinical Director of the Boston Medical Center Memory and Aging Clinic, which directly interfaces with the BU ADRC to provide clinical neuropsychological services to participants as well as to the larger community concerned for cognitive difficulties.

Research Interests

Dr. Alosco has an active and established research program that has a unique thematic focus on three areas: (1) the relationship between repetitive head impacts (RHI) and traumatic brain injury (TBI) with a later-life cognitive and neuropsychiatric decline, as well as neurodegenerative disease(s); (2) the contribution of cerebrovascular disease to the clinical and neuropathological expression of CTE, AD, and AD-related dementias (ADRD); and (3) in vivo biomarker development for CTE, AD, and ADRD with a focus on PET, structural MRI, and blood-based biomarkers.

Awards/Memberships

Dr. Alosco has multiple Editorial Board memberships. He has had numerous invitations from institutions across the country as well as internationally to present on his research.   e serves as an ad-hoc reviewer for top-tier journals and he is a member of several national and international societies, including the American Psychological Association, International Neuropsychological Society, and the Massachusetts Neuropsychological Society. He is actively involved in these societies, including through service on Program Committees and Scientific Advisory Committees. Dr. Alosco is also the recipient of multiple honors and awards.


Selected Publications

  1. Alosco M.L, Stein T.D., Tripodis Y, Chua A.S., Huber B.R., Goldstein L.E., Cantu R.C., Katz D.I., Palmisano J.N., Martin B, Cherry J.D., Mahar I, Killiany R.J., McClean M.D., Au R, Alvarez V, Stern R.A., Mez J, McKee A.C. Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol2019;76:1298-1308.
  2. Alosco M.L.,* Tripodis Y,* Baucom Z, Mez J, Stein T.D., Martin B, Haller O, Coneely S, McClean M.D., Nosheny R.L., Mackin S, McKee A.C., Weiner M.W.,** Stern, R.A.** The late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology2020;95:e793-e804.
  3. Alosco M.L.,Cherry J.D., Huber B.R., Tripodis Y, Baucom Z, Kowall N.W., Saltiel N, Goldstein L.E., Katz D.I., Dwyer B, Daneshvar D.H., Palmisano J.N., Martin B, Cantu R.C., Stern R.A., Alvarez V.E., Mez J, Stein T.D., McKee A.C. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): Utility of the McKee CTE Staging Scheme. Acta Neuropathologica 2020;140:495-512.
  4. Sugarman M.A.,McKee A.C., Stein T.D., Tripodis Y, Besser L.M., Martin B, Palmisano J.N., Steinberg E.G., O’Connor M.K., Au R, McClean M, Killiany R, Mez J, Weiner M.W., Kowall N.W., Stern R.A.,* Alosco M.L.* Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia. Alzheimers Dement 2019;15:686-698.
  5. Alosco M.L., Mez J, Tripodis Y, Kiernan P.T., Abdolmohammadi B, Murphy L, Kowall N.W., Stein T.D., Huber B.R., Goldstein L.E., Cantu R.C., Katz D.I., Chaisson C.E., Martin B, Solomon T.M., McClean M.D., Daneshvar D.H., Nowinski C.J., Stern R.A., McKee A.C. Age of first exposure to tackle football and chronic traumatic encephalopathy. Annals of Neurology2018;83:886-901.
  6. Alosco M.L., Tripodis Y, Fritts N.G., Heslegrave A, Baugh C.M., Conneely S, Mariani M, Martin B.M., Frank S, Mez J, Stein T.D., Cantu R.C., McKee A.C., Shaw L.M., Trojanowski J.Q., Blennow K, Zetterberg H, Stern R.A. Cerebrospinal fluid tau, Aβ, and sTREM2 in former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement2018;14:1159-1170.
  7. Alosco M.L., Koerte I.K., Tripodis Y, Mariania M, Chua A.S., Jarnagin J, Rahimpour Y, Puzo C, Healy R.C., Martin B, Chaisson C.E., Cantu R.C., Au R, McClean M, McKee A.C., Lin A.P., Shenton M.E., Killiany R.J., Stern R.A. White matter signal abnormalities in former National Football League players. Alzheimers Dementia (Amst) 2017;10:56-65.
  8. Alosco M.L., Kasimis A.B., Stamm J.M., Chua A.S., Baugh C.M., Daneshvar D.H., Robbins C.A., Mariani M, Hayden J, Conneely S, Au R, Torres A, McClean M.D., McKee A.C., Cantu R.C., Mez J, Nowinski C.J., Martin B.M., Chaisson C.E., Tripodis Y, Stern R.A. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl Psychiatry2017;7:1-8.

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