Michael Alosco

Background

Dr. Alosco is a licensed clinical neuropsychologist and an Associate Professor of Neurology at the Boston University Chobanian & Avedisian School of Medicine where he also serves as the Research Vice Chair, Co-Director of Clinical Research at the BU CTE Center, and Leader of the Boston University Alzheimer’s Disease Research Center Clinical Core. He completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus on neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. Dr. Alosco completed his post-doctoral studies in neuropsychology via NIH-funded training Awards (T32, F32) at the Boston University Alzheimer’s Disease Research Center and CTE Center. In 2018, he became an Assistant Professor of Neurology at the Boston University Chobanian & Avedisian School of Medicine and immediately received NIH/NINDS K23 Award. He was promoted to Associate Professor in 2019. Dr. Alosco has published extensively in the fields of Alzheimer’s disease and related dementias, including CTE, and he is the PI of multiple NIH-funded grants. His research has set the stage for biomarker discovery in CTE and the long-term effects of repetitive head impacts on the white matter, and he has made major contributions to plasma biomarker development and validation in Alzheimer’s disease. He has written numerous book chapters, and he is the co-Editor of the Oxford Handbook of Adult Cognitive Disorders which was published by Oxford University Press in 2019.

CTE Center Role

Dr. Alosco is Co-Director of Clinical Research at the BU CTE Center. He is the Project Lead of a multisite NIH/NINDS-funded U54 that is examining the late neuropathologies of exposure to repetitive head impacts and TBI and resulting clinical syndromes. He oversees studies on risk factors and clinicopathological correlations of CTE. Dr. Alosco leads several NIH-funded human subject studies devoted to biomarker development for CTE and the long-term effects of repetitive head impacts on the white matter and vasculature.

Selected Publications

1. Alosco M.L, Stein T.D., Tripodis Y, Chua A.S., Huber B.R., Goldstein L.E., Cantu R.C., Katz D.I., Palmisano J.N., Martin B, Cherry J.D., Mahar I, Killiany R.J., McClean M.D., Au R, Alvarez V, Stern R.A., Mez J, McKee A.C. Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol 2019;76:1298-1308.
2. Alosco M.L.,* Tripodis Y,* Baucom Z, Mez J, Stein T.D., Martin B, Haller O, Coneely S, McClean M.D., Nosheny R.L., Mackin S, McKee A.C., Weiner M.W.,** Stern, R.A.** The late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology 2020;95:e793-e804.
3. Alosco M.L.,Cherry J.D., Huber B.R., Tripodis Y, Baucom Z, Kowall N.W., Saltiel N, Goldstein L.E., Katz D.I., Dwyer B, Daneshvar D.H., Palmisano J.N., Martin B, Cantu R.C., Stern R.A., Alvarez V.E., Mez J, Stein T.D., McKee A.C. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): Utility of the McKee CTE Staging Scheme. Acta Neuropathologica 2020;140:495-512.
4. Sugarman M.A.,McKee A.C., Stein T.D., Tripodis Y, Besser L.M., Martin B, Palmisano J.N., Steinberg E.G., O’Connor M.K., Au R, McClean M, Killiany R, Mez J, Weiner M.W., Kowall N.W., Stern R.A.,* Alosco M.L.* Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia. Alzheimers Dement 2019;15:686-698.
5. Alosco M.L., Mez J, Tripodis Y, Kiernan P.T., Abdolmohammadi B, Murphy L, Kowall N.W., Stein T.D., Huber B.R., Goldstein L.E., Cantu R.C., Katz D.I., Chaisson C.E., Martin B, Solomon T.M., McClean M.D., Daneshvar D.H., Nowinski C.J., Stern R.A., McKee A.C. Age of first exposure to tackle football and chronic traumatic encephalopathy. Annals of Neurology 2018;83:886-901.
6. Alosco M.L., Tripodis Y, Fritts N.G., Heslegrave A, Baugh C.M., Conneely S, Mariani M, Martin B.M., Frank S, Mez J, Stein T.D., Cantu R.C., McKee A.C., Shaw L.M., Trojanowski J.Q., Blennow K, Zetterberg H, Stern R.A. Cerebrospinal fluid tau, Aβ, and sTREM2 in former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement 2018;14:1159-1170.
7. Alosco M.L., Koerte I.K., Tripodis Y, Mariania M, Chua A.S., Jarnagin J, Rahimpour Y, Puzo C, Healy R.C., Martin B, Chaisson C.E., Cantu R.C., Au R, McClean M, McKee A.C., Lin A.P., Shenton M.E., Killiany R.J., Stern R.A. White matter signal abnormalities in former National Football League players. Alzheimers Dementia (Amst) 2017;10:56-65.
8. Alosco M.L., Kasimis A.B., Stamm J.M., Chua A.S., Baugh C.M., Daneshvar D.H., Robbins C.A., Mariani M, Hayden J, Conneely S, Au R, Torres A, McClean M.D., McKee A.C., Cantu R.C., Mez J, Nowinski C.J., Martin B.M., Chaisson C.E., Tripodis Y, Stern R.A. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl Psychiatry 2017;7:1-8.