Molecular Research


The mission of the molecular research team is to discover disease mechanisms and develop new diagnostics and treatments for chronic traumatic encephalopathy and other neurodegenerative disorders, including Alzheimer’s disease (AD). The molecular research laboratory is a multidisciplinary biomedical research laboratory directed by Thor Stein, MD, PhD, based at the Boston University Chobanian & Avedisian School of Medicine and closely affiliated with the Boston University Chronic Traumatic Encephalopathy Center, Alzheimer’s Disease Research Center, Center for Biometals & Metallomics (CBM), and other worldwide laboratories.


Selected Academic Articles

1. Goldstein LE, Fisher AM, Tagge CA, Zhang X-L,Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC: Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model. Sci Trans. Med. Sci Transl Med. 2012 May 16;4(134):134ra60.PMID: 22593173

2. Response to comment on “chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model”. Goldstein LE, McKee AC. Sci Transl Med. 2012 Oct 24;4(157):157lr5. doi: 10.1126/scitranslmed.3004862. PMID: 23100626

3. Kondo A*, Shahpasand K*, Mannix R, Qiu J, Moncaster J, Chen C-H,Yao Y, Lin Y-M, Driver J, Sun Y, Wei S, Luo M-L, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein L, Pascual-Leone A, McKee A, Meehan W, Zhou X, and Lu K. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature 2015 Jul 23;523(7561):431-6. doi: 10.1038/nature14658. Epub 2015 Jul 15.