Jesse Mez

Co-Director, Clinical Research, BU CTE Center
Associate Professor of Neurology, Boston University Chobanian & Avedisian School of Medicine
Leader, Clinical Core, BU ADRC
Investigator, BU CTE Center
Co-leader, Framingham Heart Study Brain Aging Program Clinical Core



Dr. Jesse Mez is an Associate Professor of Neurology at BU School of Medicine. He directs the BU ADRC Clinical Core, is an investigator in the BU CTE Center, and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium Investigator. He joined BU’s faculty in 2013, where he has been an integral player in the field of CTE and AD. His research seeks to understand genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. Ongoing research themes include investigating 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service and dementia-related outcomes and their interaction with genetic factors, 2) clinico-pathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) the genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 100 research articles, reviews, editorials, and book chapters.

He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Partners Program in Boston.  This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.

He is the recipient of an NIH-funded K23 Career Development Award, an NIH-funded Loan Repayment Program Award, and the BU Carlos S. Kase Outstanding Contribution to Neurology Research Award and is a 2015 BU Spivack Neuroscience Scholar.

For a full list of publications, click here.

Recent Publications

For a full list of publications click here.

  • Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, Mez J, Montenigro PH, Solomon TM, Alosco ML, Stern RA, McKee AC, Stein TD. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016 Oct 28; 4(1):112. PMID: 27793189.
    View in: PubMed
  • Zahodne LB, Gilsanz P, Glymour MM, Gibbons LE, Brewster P, Hamilton J, Mez J, Marden JR, Nho K, Larson EB, Crane PK, Gross AL. Comparing Variability, Severity, and Persistence of Depressive Symptoms as Predictors of Future Stroke Risk. Am J Geriatr Psychiatry. 2017 Feb; 25(2):120-128. PMID: 27866734.
    View in: PubMed
  • Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ. Two novel loci, COBL and SLC10A2, for Alzheimer’s disease in African Americans. Alzheimers Dement. 2016 Oct 20.
    PMID: 27770636.
    View in: PubMed
  • Gavett BE, Gurnani AS, Saurman JL, Chapman KR, Steinberg EG, Martin B, Chaisson CE, Mez J, Tripodis Y, Stern RA. Practice Effects on Story Memory and List Learning Tests in the Neuropsychological Assessment of Older Adults. PLoS One. 2016; 11(10):e0164492. PMID: 27711147.
    View in: PubMed
  • Alosco ML, Mez J, Kowall NW, Stein TD, Goldstein LE, Cantu RC, Katz DI, Solomon TM, Kiernan PT, Murphy L, Abdolmohammadi B, Daneshvar D, Montenigro PH, Nowinski CJ, Stern RA, McKee AC. Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination. J Neuropsychiatry Clin Neurosci. 2016 Aug 19; appineuropsych16030043. PMID: 27539377.
    View in: PubMed
  • Montenigro PH, Alosco ML, Martin BM, Daneshvar DH, Mez J, Chaisson CE, Nowinski CJ, Au R, McKee AC, Cantu RC, McClean MD, Stern RA, Tripodis Y. Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma. 2017 Jan 15; 34(2):328-340. PMID: 27029716.
    View in: PubMed
  • Mez J, Solomon TM, Daneshvar DH, Stein TD, McKee AC. Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player. JAMA Neurol. 2016 Mar; 73(3):353-5. PMID: 26747562.
    View in: PubMed
  • Mez J, Mukherjee S, Thornton T, Fardo DW, Trittschuh E, Sutti S, Sherva R, Kauwe JS, Naj AC, Beecham GW, Gross A, Saykin AJ, Green RC, Crane PK. The executive prominent/memory prominent spectrum in Alzheimer’s disease is highly heritable. Neurobiol Aging. 2016 May; 41:115-21. PMID: 27103524.
    View in: PubMed



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