Ann McKee

Neuropathologist and expert in Neurodegenerative Diseases at New England Veterans Administration Medical Centers (VISN-1), ADC Center Associate Director, CTE Center Director, AD & CTE Center Neuropathology Core Director & Professor of Neurology & Pathology
, BUSM

Education
MD

Dr. Ann McKee, William Fairfield Warren Distinguished Professor of Neurology and Pathology, is a board-certified neurologist and neuropathologist whose research has produced seminal advances in chronic traumatic encephalopathy (CTE), Alzheimer’s disease, microvascular injury and trauma-induced neurodegeneration. Her groundbreaking work on the long-term effects of repetitive head impacts, concussion, and blast injury in contact sports athletes and military veterans shifted scientific thought regarding head trauma; her research demonstrated that repetitive “mild” head trauma can trigger CTE, a progressive neurodegenerative disease. Over the past 12 years, Dr. McKee’s publications on the clinicopathological manifestations of CTE in hundreds of affected individuals sparked international awareness regarding the dangers of repetitive head trauma and the importance of biomarker discovery to diagnose CTE during life. Dr. McKee created and directs the UNITE (VA-BU-CLF) brain bank, the world’s largest repository of brains from individuals exposed to traumatic brain injuries (over 1000) and neuropathologically confirmed CTE (over 600). The brain bank is a unique resource to accelerate scientific discovery and develop potential treatments for CTE.

McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed her residency training in Neurology at Cleveland Metropolitan General Hospital, in Neuropathology at Massachusetts General Hospital and was assistant professor at Harvard Medical School. She is Director of the Boston University CTE Center, Director of the Neuropathology Core and Associate Director for the Boston University Alzheimer’s Disease Research Center (BUADRC). McKee also directs the brain banks for the BU CTE Center (VA-BU-CLF), BUADRC and Framingham Heart Study. She is an elected member of the National Academy of Medicine. McKee was named Bostonian of the Year 2017 by the Boston Globe, one of the 100 Most Influential People in the World, and one of the 50 Most Influential People in Healthcare by Time magazine. She received the Henry Wisniewski Lifetime Achievement Award in Alzheimer’s Disease Research by the Alzheimer’s Association and Samuel J. Heyman Service to America Medal (Sammie), Paul A. Volcker Career Achievement Award for outstanding contributions to federal service.

 Research Interests

Dr. McKee’s work has been fundamental in defining the neuropathological diagnostic criteria for CTE. She created the McKee staging scheme to define pathological severity in CTE. She was the first to report the association between motor neuron disease and CTE. She reported the first case of CTE in ice hockey, soccer, mixed-martial arts, baseball, high school football, and college football. Dr. McKee reported the youngest athlete ever diagnosed with CTE (17 years). Her team was the first to define the roles of other pathological proteins in neurodegeneration after trauma, including TDP-43, beta amyloid, prion protein and alpha-synuclein. Dr. McKee also defined the roles of microvascular injury, inflammation and white matter degeneration in the progression of CTE.

Awards:

William Fairfield Warren Distinguished Professor, Boston University

Samuel J. Heyman Service to America Medal (Sammie), Paul A. Volcker Career Achievement Award for outstanding contributions to federal service

National Academy of Medicine

Time 100 Most Influential People in the World, 2018, Time Magazine

Time 50 Most Influential People in Healthcare 2018, Time Magazine

Henry Wisniewski Lifetime Achievement Award in Alzheimer’s Disease Research, Alzheimer’s Association

Bostonian of the year 2017, Boston Globe


Selected Publications

McKee AC, Winkelman MD, Banker BQ:  Central pontine myelinolysis in severely burned patients:  relationship to serum hyperosmolality.  Neurology 1988; 38: 1211-7

McKee AC, Kowall NW, Kosik KS:  Microtubular reorganization and dendritic growth response in Alzheimer’s disease.  Annals of Neurology, 1989; 26:652-9

McKee AC, Kowall NW, Kosik KS:  Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II Ca/calmodulin-dependent protein kinase.  J Neuropathol Exp Neurol, 1990; 49: 49-63

McKee AC, Kosik KS, Kowall NW:  Neuritic pathology and dementia in Alzheimer’s disease.  Annals of Neurology, 1991; 30: 156-65

McKee, AC, Au R, Cabral HJ, Kowall NW, Seshadri, S, Kubilus C, Drake J, Wolf P. Visual Association Pathology in Preclinical AD. Journal Neuropath Exp Neurol June; 65(6): 621-630.

 McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee H-Y, Kubilus CA, Stern RA. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy following Repetitive Head Injury.  J Neuropath Exp Neurol, 2009 68(7): 709-735

Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer’s disease. PLoS One. 2009 Aug 12; 4(8): e661

McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, Perl D, Hedley-Whyte E, Price B, Sullivan C, Morin P, Lee H-S, Kubilus C, Daneshvar D, Wulff M, Budson A. TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy, Journal Neuropathol Exp Neurol, 2010, 69: 918-929

Authors’ reply: McKee AC, Budson AE, Gavett BE, Stern RA, Daneshvar D, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET. J Neuropathol Exp Neurol. 2011 Jan; 70(1): 98-100

Goldstein LE, Fisher AM, Tagge CA, Zhang X-L,Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ,  Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC: Chronic Traumatic Encephalopathy inBlast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model. Sci Trans. Med. Sci Transl Med. 2012 May 16;4(134):134ra60. PMID: 22593173. Response to comment on “chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model”.Goldstein LE, McKee AC. Sci Transl Med. 2012 Oct 24;4(157):157lr5. doi: 10.1126/scitranslmed.3004862 PMID: 23100626

Au R#, Seshadri S#, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf P, McKee AC. The Framingham Brain Donation Program: Neuropathology Along the Cognitive Continuum Current Alzheimer Research, 2012, Jul;9(6):673-86

McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The Spectrum of Disease in Chronic Traumatic Encephalopathy, Brain 2013, Jan;136(Pt 1):43-64. doi: 10.1093/brain/aws307

Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013 Aug 21

Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y, Daneshvar DH, Mez J, Solomon T, Meng G, Kubilus CA, Cormier KA, Meng S, Babcock K, Kiernan P, Murphy L, Nowinski CJ, Martin B, Dixon D, Stern RA, Cantu RC, Kowall NW, McKee AC. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol. 2015 May 6

Kondo A*, Shahpasand K*, Mannix R, Qiu J, Moncaster J, Chen C-H,Yao Y, Lin Y-M, Driver J, Sun Y, Wei S, Luo M-L, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein L, Pascual-Leone A, McKee A, Meehan W, Zhou X, and Lu K. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature 2015 Jul 23;523(7561):431-6. doi: 10.1038/nature14658. Epub 2015 Jul 15

Mez J, Solomon T, Daneshvar D, Murphy L, Kiernan P, Montenigro P, Kriegel J, Abdolmohammadi B, Fry B, Babcock K, Adams J, Bourlas A, Papadopoulos Z, McHale L, Ardaugh B, Martin B, Dixon D, Nowinski C, Cjaisson C, Alvarez V, Tripodis Y, Stein T, Goldstein L, Katz D, Kowall N, Cantu R, Stern R, McKee A. Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale & methods for the UNITE study. Alzheimers Res Ther. 2015 Oct 12;7(1):62. doi: 10.1186/s13195-015-0148-8

Bieniek KF, Ross OA, Cormier KA, Walton RL, Soto-Ortolaza A, Johnston AE, DeSaro P, Boylan KB, Graff-Radford NR, Wszolek ZK, Rademakers R, Boeve BF, McKee AC, Dickson DW. Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol. 2015 Dec;130(6):877-89. doi: 10.1007/s00401-015-1502-4. Epub 2015 Oct 30

Kovacs GG , Isidro Ferrer, Lea T. Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J. Cairns, John F. Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M. Halliday, James W. Ironside, Seth Love, Ian R. Mackenzie, David G. Munoz, Melissa E. Murray, Peter T. Nelson, Hitoshi Takahashi, John Q. Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G. Beach, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Brittany N. Dugger, Mel Feany, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Kimmo J. Hatanpaa, Richard Heale, Patrick R. Hof, Monika Hofer, Tibor Hortobágyi, Kurt Jellinger, Gregory A. Jicha, Paul Ince, Julia Kofler, Enikö Kövari, Jillian J. Kril, David M. Mann, Radoslav Matej, Ann C. McKee, Catriona McLean, Ivan Milenkovic, Thomas J. Montine, Shigeo Murayama, Edward B. Lee, Jasmin Rahimi, Roberta D. Rodriguez, Annemieke Rozemüller, Julie A. Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B. Toledo, Markus Tolnay, Juan C. Troncoso, Harry V. Vinters, Serge Weis, Stephen B. Wharton, Charles L. WhiteIII, Thomas Wisniewski, John M. Woulfe, Masahito Yamada, Dennis W. Dickson. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol, 2016, Jan;131(1):87-102. doi: 10.1007/s00401-015-1509-x. Epub 2015 Dec 10.,PMID: 26659578

Mez J, Solomon TM, Daneshvar DH, Stein TD, McKee AC. Pathologically confirmed chronic traumatic encephalopathy in a 25-year-old former college football player. JAMA Neurology, 2016, Jan 4:1-3. doi: 10.1001/jamaneurol.2015.3998

Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of early pathological tau conformations and phosphorylation in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2015 Dec 15. pii: nlv001 PMID: 26671985

McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Stewart W, Vonsattel JP, Tripodis Y, Alvarez VE, Bieniek KF, Crary J, Dams-O’Connor K, Gordon W and the TBI/CTE group. The First NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. Acta Neuropathol. 2016 Jan;131(1):75-86. doi: 10.1007/s00401-015-1515-z.

 Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. A quantitative study of tau pathology in eleven cases of chronic traumatic encephalopathy.Neuropathol Appl Neurobiol. 2016 Mar 21

 Montenigro PH, Alosco ML, Martin B, Daneshvar DH, Mez J, Chaisson C, Nowinski CJ, Au R, McKee AC, Cantu RC, McClean MD, Stern RA, Tripodis Y.Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma. 2016.

 Armstrong RA, McKee AC, Cairns NJ. Pathology of the Superior Colliculus in Chronic Traumatic Encephalopathy.Optom Vis Sci. 2016 Jul 6. PMID: 27391531

Besser LM, Alosco ML, Ramirez Gomez L, Zhou XH, McKee AC, Stern RA, Gunstad J, Schneider JA, Chui H, Kukull WA.Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition.J Neuropathol Exp Neurol. 2016 Aug 11. pii: nlw072. PMID: 27516116

Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer’s Disease Pathology.J Alzheimers Dis. 2016 Jul 6. PMID: 27392855

 Alosco M, Mez J,  Kowall N, Stein T, Goldstein L, Cantu R, Katz D, Solomon T, Kiernan P, Murphy L, Abdolmohammadi B, Daneshvar Daniel, Montenigro P, Nowinski J, Stern R,  McKee AC. Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination, J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):6-12. doi: 10.1176/appi.neuropsych.16030043

 Woerman AL, Aoyagi A, Patel S, Kazmi S, Lobach I, Grinberg L, McKee A, Seeley W, Olson S, and Prusiner S. Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50): E8187-E8196

Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Inj. 2016; 30 (12):1399-1413

Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, Mez J, Montenigro PH, Solomon TM, Alosco ML, Stern RA, McKee AC, Stein TD. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016 Oct 28;4(1):112

Holleran L, Kim JH, Gangolli M, Stein T, Alvarez V, McKee A, Brody DL, Axonal disruption in white matter underlying cortical sulcus tau pathology in chronic traumatic encephalopathy, Acta Neuropathol 2017 Mar;133(3):367-380. doi: 10.1007/s00401-017-1686-x

Alosco ML, Duskin J, Besser LM, Martin B, Chaisson CE, Gunstad J, Kowall NW, McKee AC, Stern RA, Tripodis Y. Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer’s Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer’s Coordinating Center Data Set. J Alzheimers Dis. 2017;57(3):953-968. doi: 10.3233/JAD-161205

Gangolli M, Holleran L, Hee Kim J, Stein TD, Alvarez V, McKee AC, Brody DL.Quantitative validation of a nonlinear histology-MRI co-registration method using generalized Q-sampling imaging in complex human cortical white matter. Neuroimage. 2017 Jun; 153:152-167. doi: 10.1016/j.neuroimage.2017.03.059. Epub 2017 Mar 30. PMID: 28365421

Saygin ZM, Kliemann D, Iglesias JE, van der Kouwe AJW, Boyd E, Reuter M, Stevens A, Van Leemput K, McKee A, Frosch MP, Fischl B, Augustinack JC; Alzheimer’s Disease Neuroimaging Initiative. High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas. Neuroimage. 2017 May 4. pii: S1053-8119(17)30342-7. doi: 10.1016/j.neuroimage.2017.04.046 

Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 May 19;49(5): e333. doi: 10.1038/emm.2017.56

Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I; Traumatic Stress Brain Study Group. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395. doi: 10.1073/pnas.1701749114. Epub 2017 Jul 17. PMID: 28716937

Mez J, Daneshvar D, Kiernan P, Abdolmohammadi B, Alvarez V, Huber B, Alosco M, Solomon T , Nowinski C, McHale L, Cormier K, Kubilus C, Martin B, Murphy L, Baugh C, Montenigro P, Chaisson C, Tripodis Y , Kowall N, Weuve J, McClean M, Cantu R, Goldstein L, Katz D, Stern R, Stein T, McKee A. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.  JAMA. 2017 Jul 25;318(4):360-370. doi: 10.1001/jama.2017.8334. PMID:28742910

Alosco ML, Kasimis AB, Stamm JM, Chua AS, Baugh CM, Daneshvar DH, Robbins CA, Mariani M, Hayden J, Conneely S, Au R, Torres A, McClean MD, McKee AC, Cantu RC, Mez J, Nowinski CJ, Martin BM, Chaisson CE, Tripodis Y, Stern RA. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl Psychiatry. 2017 Sep 19;7(9): e1236. doi: 10.1038/tp.2017.197

 

Cherry J, Stein T, Tripodis Y, Alvarez V, Huber B, Au R, Kiernan P, Daneshvar D, Mez J, Solomon T, Alosco M, McKee A. CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease PLoS One. 2017; 12(9): e0185541

Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer’s disease. Aging Cell. 2017 Nov 11

Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J, Rahimpour Y, Puzo C, Healy RC, Martin B, Chaisson CE, Cantu RC, Au R, McClean M, McKee AC, Lin AP, Shenton ME, Killiany RJ, Stern RA. White matter signal abnormalities in former National Football League players. Alzheimers Dement (Amst). 2017 Nov 6; 10:56-65

Moszyzynski A, Strong W, Xu K, McKee A, Brown A, Strong M. Pathological Thr tau phosphorylation and its relationship to chronic traumatic encephalopathy. Neurology 2018 Jan 3

Kenney K,Iacono D, Edlow B, Katz D, Diaz-Arrastia R, Dams-O’Connor K, Daneshvar D, Stevens A, Moreau A, Tirrell L, Varjabedian A, Yendiki A, Kouwe A, Mareyam, A, McNab J, Gordon W, Fischl B, McKee A, Perl P. Dementia after Moderate-Severe Traumatic Brain Injury:  Coexistence of Multiple Proteinopathies, J Neuropathol Exp Neurol. 2018 Jan 1;77(1):50-63

Cherry JD, Zeineddin A, Dammer EB, Webster J, Duong D, Seyfried NT, Levey AI, Alvarez VE, Huber B, Stein TD, Kiernan PT, McKee AC, Lah JJ, Hales CM.mCharacterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy, J Neuropathol Exp Neurol. 2018 Jan 1;77(1):40-49

Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Huber BR, Stein TD, Lamb BT, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE*. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain, 2018, Feb 1;141(2):422-458

Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of First Exposure to Tackle Football and Chronic Traumatic Encephalopathy. Ann Neurol. 2018 Apr 30. doi: 10.1002/ana.25245, PMID:30053297

Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aβ, and sTREM2 in former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers and Dementia, 2018 Jul 23. pii: S1552-5260(18)30158-4. doi: 10.1016/j.jalz.2018.05.004. PMID: 30049650

Adams J, Alvarez V, Mez J, Huber B, Tripodis Y, Xia W, Meng G, Kubilus C, Cormier K, Kiernan P, Daneshvar D, Chua A, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon T, Cherry J, Aytan N, Mahar I, Devine S, Auerbach S, Alosco M, Nowinski C, Kowall N, Goldstein L, Dwyer B, Katz D, Cantu R, Stern R, Au R, McKee A, Stein T. Lewy body pathology and chronic traumatic encephalopathy associated with contact sports. J Neuropath Exp Neurol, 2018 Jul 25, doi: 10.1093/jnen/nly065

Astrocytic degeneration in chronic traumatic encephalopathy. Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Acta Neuropathol. 2018 Sep 7. doi: 10.1007/s00401-018-1902-3

Walt G, Burris H, Brady C, Spencer  K, Alvarez V, Huber B, Guilderson L, Rauf A, Collins D, Singh T, Mathias R, Averill J, Walker S, Robey I, McKee Ann, Kowall N, Stein T. Chronic traumatic encephalopathy within an amyotrophic lateral sclerosis brain bank cohort. J Neuropath Exp Neurol, 2018 Dec 1;77(12):1091-1100

Cherry* J, Mez J*, Crary J Tripodis Y, Alvarez V, Mahar  I, Huber B, Alosco M, Nicks R, Abdolmohammadi B, Kiernan P, Evers L, Svirsky S, Babcock K , Gardner H, Meng G, Nowinski C, Martin B, Kowall N, Cantu R, Goldstein L, Katz D, Stern R, Lindsay A. Farrer L, McKee  A#, Stein T#. Variation in TMEM106B and Chronic Traumatic Encephalopathy. Acta Neuropathologica Comm, 2018 Nov 4;6(1):115

Morrison F, Miller M, Wolf E, Logue M; Maniates H, Kwasnik D, Cherry J; Svirsky S, Restaino A, Hildebrandt A, Naytan N, Stein T,Alvarez V, McKee A, Huber B. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neuroscience Letters, 2018, Oct 23;692:204-209

Nemani S, NotariS, Cali I, Alvarez V, Kofskey D, Cohen M, Stern R, Appleby B, Abrams J, Schonberger L, McKee A, Gambetti P. Co-occurrence of chronic traumatic encephalopathy and prion disease. Acta Neuropathol Commun. 2018 Dec 18;6(1):140. doi: 10.1186/s40478-018-0643-9

Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. Cortical degeneration in chronic traumatic encephalopathy and Alzheimer’s disease neuropathologic change.

Neurol Sci. 2018 Dec 18. doi: 10.1007/s10072-018-3686-6 

Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O’Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia. Alzheimers Dement. 2019 Mar 6

Alosco ML, Tripodis Y, Rowland B, Chua AS, Liao H, Martin B, Jarnagin J, Chaisson CE, Pasternak O, Karmacharya S, Koerte IK, Cantu RC, Kowall NW, McKee AC, Shenton ME, Greenwald R, McClean M, Stern RA, Lin A. A magnetic resonance spectroscopy investigation in symptomatic former NFL players. Brain Imaging Behav. 2019 Mar 8. doi: 10.1007/s11682-019-00060-4

Signaevsky M, Prastawa M, Farrell K, Tabish N, Baldwin E, Han N, Iida MA, Koll J, Bryce C, Purohit D, Haroutunian V, McKee AC, Stein TD, White CL 3rd, Walker J, Richardson TE, Hanson R, Donovan MJ, Cordon-Cardo C, Zeineh J, Fernandez G, Crary JF.

Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.Lab Invest. 2019 Feb 15. doi: 10.1038/s41374-019-0202-4

Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 Jun 10. doi: 10.1007/s00401-019-02031-x

Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Jun 27. doi: 10.1007/s12031-019-01356-2

Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H. Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy. Exp Neurobiol. 2019 Jun;28(3):362-375. doi: 10.5607/en.2019.28.3.362. Epub 2019 Jun 26

Puzo C, Labriola C, Sugarman MA, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Stein TD, Kowall NW, McKee AC, Mez J, Killiany RJ, Stern RA, Alosco ML. Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set. Alzheimers Res Ther. 2019 Jul 27;11(1):64. doi: 10.1186/s13195-019-0521-0. PMID: 31351489

Alosco ML, Stein TD, Tripodis Y, Chua AS, Kow?.\all NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, Martin B, Cherry JD, Mahar I, Killiany RJ, McClean MD, Au R, Alvarez V, Stern RA, Mez J, McKee AC. Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. JAMA Neurol. 2019 Aug 5. doi: 10.1001/jamaneurol.2019.2244. PMID:31380975

Marta Marquié, M.D., Ph.D.; Cinthya Agüero, M.D., Ph.D.; Ana C. Amaral, Ph.D.; Alberto Villarejo-Galende, M.D., Ph.D.; Prianca Ramanan, B.A.; Michael Siao Tick Chong, B.A.; Nil Sáez-Calveras; Rachel E. Bennett, Ph.D.; Eline E. Verwer, Ph.D.; Sally Ji Who Kim, Ph.D.; Maeva Dhaynaut, M.S.; Keith A. Johnson, M.D.; Ann C. McKee, M.D.; Matthew P. Frosch, M.D., Ph.D.; Victor E. Alvarez, M.D.; Teresa Gomez-Isla, M.D., Ph.D. [18F]-AV-1451 binding profile in Chronic Traumatic Encephalopathy: a postmortem case series Acta Neuropathologica Communications, 2019 Oct 28;7(1):164. doi: 10.1186/s40478-019-0808-PMID:31661038

Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Ann Clin Transl Neurol. 2019 Dec;6(12):2403-2412. doi: 10.1002/acn3.50936. Epub 2019 Nov 5.

Minaeva O, Hua N, Franz ES, Lupoli N, Mian AZ, Farris CW, Hildebrandt AM, Kiernan PT, Evers LE, Griffin AD, Liu X, Chancellor SE, Babcock KJ, Moncaster JA, Jara H, Alvarez VE, Huber BR, Guermazi A, Latour LL, McKee AC, Soto JA, Anderson SW, Goldstein LE. Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans. Radiology. 2020 Feb;294(2):377-385. doi: 10.1148/radiol.2019190461. Epub 2019 Nov 26

Mez J, Daneshvar D, Abdolmohammadi B, Chua A, Alosco M, Kiernan P, Evers L, Marshall L, Martin B, Palmisano J, Nowinski C, Mahar I, Cherry J, Alvarez V, Dwyer B, Huber B, Stein T, Goldstein L, Katz D, Cantu R, Au R, Kowall N, Stern R, McClean M, Weuve J, Tripodis Y, McKee A. Duration of American football play and chronic traumatic encephalopathy, Ann Neurol. 2020 Jan;87(1):116-131. doi: 10.1002/ana.25611. PMCID: PMC6973077.

Reply to “Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy”.

Mez J, Daneshvar DH, Alosco ML, Alvarez VE, Huber BR, Stein TD, McKee AC. Ann Neurol. 2020 Aug 4. doi: 10.1002/ana.25858. Online ahead of print.PMID: 32754941

Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR; Alzheimer’s Disease Genetics Consortium. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 Feb 3;11(1):667. doi: 10.1038/s41467-019-14279-8.PMID: 32015339

Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M; An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Traumatic Stress Brain Study Group.Clin Epigenetics. 2020 Mar 14;12(1):46. doi: 10.1186/s13148-020-0820-0.PMID: 32171335

Lee MY, Lee J, Hyeon SJ, Cho H, Hwang YJ, Shin JY, McKee AC, Kowall NW, Kim JI, Stein TD, Hwang D, Ryu H. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer’s disease. Aging Cell. 2020 Jun;19(6): e13153. doi: 10.1111/acel.13153. Epub 2020 May 17. PMID: 32419307

Cho H, Hyeon SJ, Shin JY, Alvarez VE, Stein TD, Lee J, Kowall NW, McKee AC, Ryu H, Seo JS. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Sci Rep. 2020 Jun 1;10(1):8811. doi: 10.1038/s41598-020-65916-y.PMID: 32483284

Cherry JD, Kim SH, Stein TD, Pothast MJ, Nicks R, Meng G, Huber BR, Mez J, Alosco ML, Tripodis Y, Farrell K, Alvarez VE, McKee AC, Crary JF. Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain Pathol. 2020 Sep;30(5):913-925. doi: 10.1111/bpa.12867. Epub 2020 Jul 2. PMID: 32500646

Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisano JN, Steinberg EG, Simkin I, Budson AE, Killiany R, O’Connor MK, Au R, Qiu WWQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer’s disease. Neurobiol Aging. 2020 Oct; 94:60-70. doi: 10.1016/j.neurobiolaging.2020.05.011. Epub 2020 May 29. PMID: 32585491

Alosco ML, Tripodis Y, Baucom ZH, Mez J, Stein TD, Martin B, Haller O, Conneely S, McClean M, Nosheny R, Mackin S, McKee AC, Weiner MW, Stern RA. Late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology. 2020 Aug 18;95(7):e793-e804. doi: 10.1212/WNL.0000000000010040. Epub 2020 Jun 26. PMID: 32591472

Spencer KR, Foster ZW, Rauf NA, Guilderson L, Collins D, Averill JG, Walker SE, Robey I, Cherry JD, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB, Stein TD. Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans. Brain Pathol. 2020 Jul 7. doi: 10.1111/bpa.12876. Online ahead of print. PMID: 32633852

Alosco ML, Cherry JD, Huber BR, Tripodis Y, Baucom Z, Kowall NW, Saltiel N, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Palmisano JN, Martin B, Cantu RC, Stern RA, Alvarez VE, Mez J, Stein TD, McKee AC. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme. Acta Neuropathol. 2020 Oct;140(4):495-512. doi: 10.1007/s00401-020-02197-9. Epub 2020 Aug 11.PMID: 32778942

Warling A, Uchida R, Shin H, Dodelson C, Garcia ME, Shea-Shumsky NB, Svirsky S, Pothast M, Kelley H, Schumann CM, Brzezinski C, Bauman MD, Alexander A, McKee AC, Stein TD, Schall M, Jacobs B.J Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration. Comp Neurol. 2020 Sep 1. doi: 10.1002/cne.25022. Online ahead of print. PMID: 328693167.

Adams JW, Alosco ML, Mez J, Alvarez VE, Huber BR, Tripodis Y, Adler CH, Kubilius C, Cormier KA, Mathais R, Nicks R, Kelley HJ, Saltiel N, Uretsky M, Nair E, Aytan N, Cherry JD, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy. Acta Neuropathol. 2020 Sep 17. doi: 10.1007/s00401-020-02206-x. Online ahead of print.PMID: 32939646

Zlokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, González HM, Schneider J, Wellington CL, Katusic ZS, Stoeckel L, Anderson D, Koenig JI, Corriveau RA, Fine L, Galis ZS, Reis J, Wright JD, Chen J. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020 Oct 8. doi: 10.1002/alz.12157. Online ahead of print. PMID: 33030307

Alosco ML, Tripodis Y, Baucom ZH, Mez J, Stein TD, Martin B, Haller O, Conneely S, McClean M, Nosheny R, Mackin S, McKee AC, Weiner MW, Stern RA.  Late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology. 2020 Aug 18;95(7):e793-e804. doi: 10.1212/WNL.0000000000010040. Epub 2020 Jun 26. PMID: 32591472

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