- Title Associate Professor of Biology
- Education PhD, Johns Hopkins University, Baltimore
- Web Address http://people.bu.edu/hfrydman/home.html
- Email email@example.com
- Phone 617-358-5070
- Area of Interest host-microbe interactions at the molecular, cellular and organismal level; mechanisms of bacterial transmission through stem-cell niche infection
My research generally focuses on understanding how microorganisms and their hosts interact at different biological levels (e.g., molecular, cellular, genetic, ecological, and evolutionary). Specifically, I am interested in the interactions of the intracellular bacteria Wolbachia with their host cells. The infection of invertebrates by Wolbachia represents one of the great pandemics on this planet. Even though Wolbachia is one of the most abundant intracellular bacteria on earth, infecting up to 70% of arthropods and filarial nematodes, their mechanisms of transmission are poorly understood.
Beyond fundamental questions of host-microbe interactions, understanding Wolbachia biology also has specific medical relevance. Wolbachia provides new approaches to treat human and animal filariasis—devastating diseases including river blindness and elephantiasis—caused by parasitic worms. Wolbachia is also a potential agent to control insect vectors that transmit diseases such as dengue, filariasis, and malaria.
The broad aim of my laboratory is to identify the mechanisms required for maintenance of Wolbachia infection through successive generations of their host (vertical transmission) and for infection into new hosts (horizontal or infectious transmission). My work demonstrates that Wolbachia preferentially populate the stem cell niche, the region of the fly ovary containing the stem cells. Tropism for the stem cell niche provides a previously undetected route to reach the germ line. The targeting of stem cell niche by Wolbachia may facilitate their horizontal and vertical transmission. Our main focus is to understand the mechanisms of Wolbachia targeting of the stem cell niche and how it relates to their successful transmission.
- Kamath AD, Deehan MA, Frydman HM (2018) “Polar cell fate stimulates Wolbachia intracellular growth.” Development 145(6): DOI:10.1242/dev.158097.
- Schultz MJ, Tan AL, Gray CN, Isern S, Michael SF, Frydman HM, Connor JH (2018)
Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication. mBio, 9(3): DOI:10.1128/mBio.00738-18.
- Simhadri RK, Fast EM, Guo R, Schultz MJ, Vaisman N, Ortiz L, Bybee J, Slatko BE,
Frydman HM (2017) “The Gut Commensal Microbiome of Drosophila melanogaster Is Modified by the
Endosymbiont Wolbachia. mSphere 2(5): DOI:10.1128/mSphere.00287-17.
- Toomey M, Frydman HM (2014) Extreme Divergence of Wolbachia Tropism for the Stem-Cell-Niche in the Drosophila Testis. PLoS Pathogens 10(12): DOI:10.1371/journal.ppat.1004577.
- Toomey ME, Panaram K, Fast EM, Beatty C, & Frydman HM (2013) Evolutionarily conserved Wolbachia-intrinsic factors control differential stem cell niche tropism in the Drosophila ovary and enhance vertical transmission. PNAS 110(26): DOI:10.1073/pnas.1301524110.
- Fast E, Toomey M, Panaram K, Desjardins D, Kolaczyk E, Frydman HM (2011). Wolbachia enhance Drosophila stem cell proliferation and target the germline stem cell niche. Science, 334(6058): 990-2.
- Frydman HM, Li JM, Robson DN, Wieschaus E (2006) Somatic stem cell niche tropism in Wolbachia. Nature 441: 509-512.
- Frydman HM (2006). Isolation of live bacteria from adult insects. Nature Protocols: DOI:10.1038/nprot.2006.131.
- BI 411/611 Microbiome
- BI 551 Stem Cell Biology