Ph.D. student, Siggers Lab
Current Research:
Transcription factors (TFs) regulate transcription by binding to cis-regulatory elements within the DNA. These TFs recruit cofactors (COFs) which then modulate DNA through a variety of mechanisms such as histone modifications, chromatin remodeling, and scaffolding for transcriptional machinery. Our lab uses protein-binding microarrays (PBMs) to study these DNA-TF-COF interactions. While these arrays offer a well established way to probe these interactions, there are certain limitations we would like to address. Currently, I am developing a novel high-throughput method to study these DNA-TF-COF interactions.