Tagged: Adrian Whitty
Professor Adrian Whitty has received a Templeton Award for Excellence in Student Advising in recognition of his strong and demonstrated commitment to the personal and academic development of his students. The award is presented each year at the College of Arts and Sciences Class Day ceremony.
In announcing the award, Dr. Steven Jarvi, Associate Dean for Student Academic Life, stated that the theme that emerged from the comments of Professor Whitty’s advisees is his sincerity and genuine interest in the well being of his students.
An international student commented that “he is from Europe, just like me, and he is interested in how my life is and how I’m adapting to America.” Another student mentioned that Professor Whitty “is the most kind-hearted and caring professor that I had the fortune to have class with.”
This 2011 award is the fourth time in a row that it has been conferred on a member of the Chemistry faculty. Previous winners have included, Sean Elliott (2008, an inaugural awardee), John Snyder (2009), and Binyomin Abrams (2010).
The Endowed Fund was established in 2008 with gifts from John and Josephine Templeton as a measure of their gratitude to the dedication shown by members of the Boston University faculty in the personal counseling, guidance, and advice they give to undergraduates.
Professor of Chemistry Karen Allen and Associate Professor of Chemistry Adrian Whitty gave a “Discoveries” talk to BU Alumni on December 1, 2010. Sponsored by the BU Alumni Association and the College of Arts & Sciences, the Discoveries lecture series taps the strength of BU faculty to give alumni a deeper look into the world and their lives.
The seminar, Lessons to be Learned from Cells: From Molecular Basis to Disease, highlighted advances and obstacles in current drug discovery and described how work at Boston University on NEMO, a protein in the pathways involved in human inflammatory diseases and cancers, aims to address critical problems.
There are many medically important drug targets that current drug discovery technology is not able to address. Collaborative basic research in Chemistry, Biology, and Biochemistry is key to solving these intractable problems to enable the discovery of new classes of drugs. A multidisciplinary team at Boston University, led by Associate Professor of Chemistry Adrian Whitty, aims to develop new approaches for challenging molecular targets. The National Institute of General Medical Sciences awarded this team a 4-year, $1.6 million grant entitled Design of Macrocyclic Inhibitors of the NEMO/IKKα/β Protein-Protein Interaction.
Only about 10% of the potential drug targets in the human genome have been successfully targeted with marketed drugs. Of the remaining 90%, many are intracellular proteins whose function is critically dependent on their reversible interactions with other proteins. Despite decades of effort by the pharmaceutical industry, developing oral drugs that inhibit protein-protein interactions (PPIs) has rarely succeeded and has become recognized as a major scientific and technological challenge.
The primary goal of this project is to determine whether the use of a class of natural product-inspired compounds called macrocycles constitutes a broadly applicable method for developing oral drugs against PPI targets. As a first challenge, the team is attempting to develop macrocycles that block the activity of NEMO, a key component of the IKK complex that activates NF-κB signaling. Chronic hyperactivity of the NF-κB pathway is associated with many human inflammatory diseases and cancers. Thus, the development of drug-like inhibitors of this pathway is highly relevant to public health.
The work will determine whether appropriately designed synthetic macrocycles can inhibit PPI targets while maintaining good drug-like properties. In terms of NF-κB and disease, their work will provide a means for testing whether inhibiting the interaction of NEMO with IKK—as a more targeted alternative to completely ablating all IKK activity—represents a useful new approach for attenuating inflammation.
In addition to Professor Whitty (quantitative biochemistry and drug discovery), the multidisciplinary research team comprises Professors Sandor Vajda and Dima Kozakov (computational chemistry), John Porco and Aaron Beeler (macrocycle synthesis), Karen Allen (X-ray crystallography), and Tom Gilmore (NF-κB pathway biology).