The ENACT is the largest federated network for regulatory-compliant EHR-based research.  ENACT is a multi-center, real-time, open-access platform that allows researchers to explore and validate feasibility for clinical studies using aggregated electronic health record data from over 125M patients nationwide. Investigators are able to query the network in real-time and to obtain aggregate counts of patients who meet clinical trial inclusion and exclusion criteria from U.S. sites. The ENACT network infrastructure provides a basis for cohort discovery and for developing new informatics tools to identify and recruit participants for multi-site clinical trials.

TriNetX is a cloud-based informatics platform that allows users to analyze aggregate patient populations and facilitate clinical research, study design, and clinical trial recruitment. Investigators at Boston Medical Center and Boston University have access to BMC’s de-identified patient data through a self-service, user-friendly interface and state-of-the-art visualization and analytic functions. TriNetX helps investigators explore patient populations in depth and demonstrate study feasibility in funding proposals and IRB submissions.

For general information and how to gain access to this platform please click here.
For a quick start guide for using TriNetX please click here.

• The N3C COVID Enclave is a public-private-government partnership established during the Coronavirus pandemic to create a centralized data resource aimed at improving the efficiency and accessibility of analyses with COVID-19 clinical data, expanding our ability to analyze and understand COVID, and demonstrating a novel approach for collaborative pandemic data sharing. By leveraging our collective data resources, unparalleled analytics expertise, and medical insights from expert clinicians, we can synergize discoveries that address the pandemic beyond the sum of our parts.
• The mission of the N3C Education Tenant is to provide educators and learners a space to develop and practice the skills needed to analyze real-world data (RWD, e.g., non-clinical trial data, such as data from medical records, insurance claims, patient surveys, or census or community datasets). The Education Tenant provides simulated (also known as ‘synthetic’ or notional) datasets to learn on, as well as a series of training tutorials, the Researcher’s Guide to the N3C – a virtual textbook of the concepts and skills needed to study RWD, and access to many of the shared resources available to the broader N3C community.
• The National Clinical Cohort Collaborative (N3C) Cancer Tenant is part of a broader feasibility testing initiative being done to refine the overall governance, data linkage, and institutional partnership components of N3C. The objective of the Cancer Tenant is to test the feasibility of linking data from multiple sources to generate a comprehensive data tenant.
• The National Clinical Cohort Collaborative (N3C) Renal Tenant is part of a broader feasibility testing initiative being done to refine the overall governance, data linkage, and institutional partnership components of N3C. The objective of the Renal Tenant is to test the feasibility of a “Freeport” Inter-HHS agency data-sharing enclave, and to better understand and conceptualize the patient journey through CKD to dialysis, transplant, and beyond.

The PaTH Network utilizes Patient Empowered Research to address the questions and concerns that matter most to our communities in order to make better health decisions.  PaTH is a Clinical Research Network comprised of Boston Medical Center, Geisinger, Johns Hopkins University, Johns Hopkins Health System, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, RUSH, Temple Health System, Lewis Katz School of Medicine at Temple University, the University of Pittsburgh, UPMC and UPMC Health Plan, The Ohio State University, The Ohio State University Wexner Medical Center, University of Michigan, and Michigan Medicine. By working together as one network, research can be done in larger and more diverse populations than a single health care system. PaTH works directly with patients, care providers, and the larger health care community to better understand what’s most relevant to patients and improve care delivery.