39 result(s) found.

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  Michael Alosco

  Associate Professor Neurology

  Dr. Alosco completed his undergraduate studies at Providence College and he earned his doctoral degree in clinical psychology, with a focus in neuropsychology, in 2015 from Kent State University. He completed his clinical internship in neuropsychology at the VA Boston Healthcare System. In 2015, Dr. Alosco was awarded a post-doctoral fellowship at the Boston University […]
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  Rhoda Au

  Professor of Anatomy & Neurobiology

  Rhoda Au is a Professor of Anatomy & Neurobiology, Neurology, and Epidemiology at Boston University Schools of Medicine and Public. She serves as one of the PIs of the Framingham Heart Study - Brain Aging Program and is also the Director of Neuropsychology. She is also Director of Global Cohort Development for the Davos Alzheimer’s […]
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  Lynne Chantranupong

  Assistant Professor of Biology

  Neurons are extremely specialized cells. They can generate intense electrical activity, maintain highly complex morphologies, and survive our entire lifetimes. Moreover, neurons are incredibly diverse, exhibiting a wide range of activity states, shapes, and sizes. These specializations confer different needs and liabilities to neurons, which they must address by adapting their molecular pathways to maintain […]
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  Jerry Chen

  Assistant Professor, Biology

  Investigating Long-Range Neocortical Networks: A longstanding goal in neuroscience is to achieve a complete understanding of the central nervous system, from the brain as a whole all the way down to individual neurons and synapses. A fundamental challenge in achieving this goal is bridging knowledge gaps impeded by the difficulty in integrating experimental measurements across […]
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  Brian DePasquale

  Assistant Professor, Biomedical Engineering

  The DePasquale lab develops mathematical models to understand how populations of neurons perform computations to produce behavior. Broadly, we take two approaches. One is data-driven: we collaborate with experimental neuroscientists to develop tailored machine learning models of neural activity to identify the algorithms that drive behaviors such as decision-making or movement. Our second approach is […]
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  Anna Devor

  Professor, Biomedical Engineering

  We are an imaging lab. We specialize in imaging neuronal, glial, vascular, and metabolic activity in brains of living and behaving experimental animals. We also use stem-cell-derived human neuronal networks. We focus on obtaining high resolution, sensitivity and specificity optical measurements and combine optical imaging with electrophysiological recordings and functional Magnetic Resonance Imaging (fMRI). Our […]
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  Michael Economo

  Assistant Professor, Biomedical Engineering

  Prof. Economo’s laboratory studies the structure and function of the neural circuits distributed across the brain that control movement. His research leverages cutting edge optical, electrophysiological, and genetic tools for recording and manipulating neural activity during behavior and for illuminating the structure of neural circuits.
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  David Farb

  Professor and Chair, Pharmacology & Experimental Therapeutics

  As head of the Laboratory of Molecular Neurobiology, Prof. Farb focuses on the identification of pharmacological treatments for disorders of learning and memory function. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers such as neuroactive steroids upon fundamental hippocampal systems […]
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  Lindsay A. Farrer

  Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics

  Dr. Lindsay Farrer is a medical geneticist at Boston University Schools of Medicine and Public Health where he is the Boston University Distinguished Professor of Genetics, Chief of Biomedical Genetics, and a Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics. Dr. Farrer is a graduate of the University of North Carolina in Chapel Hill, received […]
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  Christopher Gabel

  Assistant Professor, Physiology & Biophysics

  Prof. Gabel's research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual […]
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  Jeffrey Gavornik

  Assistant Professor, Biology

  The basis of all cognitive function is communication between neurons in the brain. This communication is mediated by synaptic connections that are modified by experience to encode function. In order to get at the big question of “how the brain works,” I study how experience-driven synaptic plasticity changes local neocortical physiology. I am particularly interested […]
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  Xue Han

  Professor, Biomedical Engineering

  Brain disorders represent the biggest unmet medical need, with many disorders being untreatable, and most treatments presenting serious side effects. Accordingly, we are discovering design principles for novel neuromodulation therapies. We invent and apply a variety of genetic, molecular, pharmacological, optical, and electrical tools to correct neural circuits that go awry within the brain. As […]
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  David Harris

  Professor and Chair, Biochemistry

  My laboratory investigates the molecular and cellular mechanisms underlying two classes of human neurodegenerative disorders: prion and Alzheimer’s diseases. Alzheimer’s disease afflicts 5 million people in the U.S., a number that will increase dramatically as the population ages. Prion diseases are much rarer, but are of great public health concern because of the global emergence […]
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  Michael Hasselmo

  Professor, Psychological & Brain Sciences Director, Center for Systems Neuroscience

  Research in the Hasselmo Laboratory concerns the cortical dynamics of memory-guided behavior, including effects of neuromodulation and theta rhythm oscillations in cortical function. Neurophysiological techniques are used to analyze intrinsic and synaptic properties of cortical circuits in rodents and to explore the effects of modulators on these properties. Computational modeling is used to link these […]
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  Angela Ho

  Associate Professor, Biology

  Brain function requires proper networking and communication between neurons. Brain development is a complex process that involves the movement and proper connectivity of neurons. Mutations in certain genes lead to improper neuron movement and brain development that often lead to severe learning disabilities in children. We are studying a specific pathway that controls one aspect […]
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  Mark Howe

  Assistant Professor, Psychological & Brain Sciences

  My laboratory seeks to identify neural circuit principles responsible for adaptively motivating, selecting, and learning actions in changing environments. We focus on the basal ganglia, a set of brain regions implicated in regulating motor and cognitive functions on multiple timescales. A range of techniques are employed including two-photon microscopy, fiber photometry, and electrophysiology in behaving […]
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  Plamen Ivanov

  Research Professor, Physics

  Prof. Ivanov's research interests include: Physiological and neural control of cardiac, locomotor, circadian, and sleep rhythms. Network physiology, particularly the interactions between integrated physiologic systems. Nonlinear dynamics and coupling, fractal and multifractal stochastic processes, stochastic feedback, and phase synchronization. Excitable media, particularly myocardial tissue. Phase transitions in physical and biological systems.
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  Robert M. Joseph

  Associate Professor, Anatomy & Neurobiology

  Prof. Joseph received his doctorate in Clinical Psychology from the University of Massachusetts in 1996. He completed postdoctoral training in developmental neuropsychology in the Department of Psychiatry at Cambridge Hospital/Harvard Medical School. Prof. Joseph has been a faculty member of the Department of Anatomy and Neurobiology since 2001. Prof. Joseph researches the neuropsychology and neurobiology […]
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  Nancy Kopell

  Professor, Mathematics & Statistics

  For the last two decades, Prof. Kopell has worked on mathematical problems in neuroscience. Her current interests parallel the themes of the Cognitive Rhythms Collaborative: how does the brain produce its dynamics (physiological mechanisms), how do brain rhythms take part in cognition (sensory processing, attention, memory, motor control), and how can pathologies of brain dynamics […]
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  Mark Kramer

  Professor, Mathematics & Statistics

  Prof. Kramer's research focuses on interdisciplinary topics in mathematical neuroscience with particular emphasis on biophysical models of neural activity and data analysis techniques. He is currently interested in medical applications and networks in neuroscience.
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  Jen-Wei Lin

  Associate Professor, Biology

  My main research focus is on the biophysical events underlying transmitter release. Neurotransmitter secretion involves ion channel gating, diffusion and buffering of calcium ions, vesicular fusion as well as the mobilization and recycling of, synaptic vesicles. We use electrophysiological and imaging techniques to monitor processes underlying synaptic transmission at a high time resolution. Using the […]
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  Jennifer Luebke

  Professor, Anatomy & Neurobiology

  Prof. Luebke maintains a laboratory in which whole-cell patch-clamp and intracellular filling techniques are used to examine the electrophysiological and morphological properties of neurons in in vitro slices of monkey and transgenic mouse neocortex. Research is focused on action potential firing patterns (and underlying ionic currents), glutamatergic and GABAergic synaptic response properties and detailed dendritic […]
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  Heng-Ye Man

  Professor of Biology

  Our research interests are focused on brain development, especially neuronal migration, morphogenesis, synapse formation, glutamate receptors and synaptic plasticity. We aim to understand the cellular and molecular processes implicated in neurodegenerative diseases and developmental disorders including autism, Angelman syndrome, intellectual disability and Alzheimer’s disease. We use diverse techniques including biochemistry, immunofluorescent staining, live imaging, virus […]
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  Maria Medalla

  Associate Professor, Anatomy & Neurobiology

  Prof. Medalla received her Ph.D. in Applied Anatomy and Physiology at the Boston University Department of Health Sciences in 2008, working with Prof. Helen Barbas to study the structure of ‘cognitive control’ pathways in the prefrontal cortex (PFC) of non-human primates. Her studies in this lab were the first to utilize triple-labeling methods for electron […]
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  Gabriel Ocker

  Assistant Professor, Mathematics & Statistics

  I work in theoretical neuroscience, studying structure-function relations in neuronal network models. How does neural activity encode sensory information and drive behavior? How do neural circuits evolve, learn, and adapt to shape that activity? How does that connectivity shape activity, and what computations does that activity perform? My group studies models of neural circuits, often […]
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  Steve Ramirez

  Associate Professor, Psychological & Brain Sciences

  The mission of my lab is twofold: to reveal the neural circuit mechanisms of memory storage and retrieval, and to artificially modulate memories to combat maladaptive states. We will do so in a multi-disciplinary fashion by combining virus engineering strategies, immunohistochemistry and physiology, optogenetics and functional imaging of targeted populations in vivo, and a battery […]
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  Douglas Rosene

  Professor, Anatomy & Neurobiology

  Prof. Rosene is recognized as one of the world’s experts on the anatomy of the temporal lobe limbic system and has published extensively in this area. He is also recognized for his work in the neurobiology of cognitive aging and was Program Director for 15 years of a long-standing NIH Program Project studying the neural […]
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  Jean-Pierre Roussarie

  Assistant Professor, Anatomy & Neurobiology

  The Roussarie lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. Dr. Roussarie thinks that understanding the particularities […]
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  Shelley Russek

  Professor, Pharmacology & Experimental Therapeutics

  The Russek Laboratory's chief interests surround a desire to understand how the dynamic regulation of neurotransmitter receptors in the brain shapes the development of the nervous system and how the re-establishment of developmental processes in the adult brain can precipitate neurologic and neuropsychiatric diseases. The identification of gene families with multiple genes that code for […]
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  Jean-Jacques Soghomonian

  Associate Professor, Anatomy & Neurobiology

  Prof. Soghomonian directs the Laboratory for the Cellular Biology of the Basal Ganglia. The laboratory currently focuses on neurotransmitter imbalances in the basal ganglia and their contribution to movement, learning, and cognitive disorders. The laboratory uses a combination of anatomical, neurochemical and molecular biology techniques.
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  Emily Stephen

  Assistant Professor, Mathematics & Statistics

  As a member of the Department of Mathematics and Statistics, I work on statistical modeling and analysis of neural recordings across spatial scales. Propagation of electrical and magnetic fields in the brain depends on both static anatomical features and state-dependent dynamical features like coherence, neuromodulation, and active pathways. My work involves constructing models that use […]
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  Tuan Leng Tay

  Assistant Professor, Biology

  How do the different types of glial cells, such as astrocytes and microglia, support the healthy development of the brain? They are important in the maintenance and (immune) protection of our nervous system. In disease and injury, glial cells alter themselves in response to a disrupted steady state, potentially to restore health to their neuronal […]
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  Julia TCW

  Assistant Professor, Pharmacology & Experimental Therapeutics

  Prof. TCW is interested in understanding Alzheimer’s disease. Her research is focused on a mutant form of Apolipoprotein E (APOE), a major genetic risk factor for Alzheimer’s disease. These studies will provide an opportunity to evaluate the APOE genetic contribution to neurodegeneration associated with the disease by using brain cells derived from human induced pluripotent […]
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  Michael Wallace

  Assistant Professor, Anatomy & Neurobiology

  The Wallace lab studies how specific circuits within the basal ganglia (BG) guide motivated behaviors, control goal-directed motor actions, and how these circuits are affected in disease. The lab has expertise in electrophysiology, molecular biology, genetics, in vivo optogenetics, computer programming, and in behavioral and imaging techniques. We apply these techniques and knowledge of BG […]
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  John White

  Professor & Chair, Biomedical Engineering

  Prof. White’s laboratory uses engineering approaches to understand how information is processed in the brain, with the goal of exploiting these findings to improve the human condition. Ongoing and future research questions include the following: Why is coherent electrical activity of the cortex necessary for mental processes like learning and memory? What factors control this […]
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  Benjamin Wolozin

  Professor, Pharmacology & Neurology

  The goal of our research is to understand the mechanisms underlying neurodegenerative diseases, and then to use this understanding to develop novel interventions for disease. Much of our research focuses on the central concept of regulated protein aggregation. Protein aggregation in neurodegenerative diseases is classically thought to occur as an unwanted byproduct of protein misfolding. […]
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  Meg Younger

  Assistant Professor, Biology

  Meg earned a BS in neural science with honors in 2004 from New York University. As an undergraduate, she worked with Justin Blau at NYU on circadian rhythms in Drosophila and with David Spray at Albert Einstein College of Medicine on mammalian gap junction channels. She went on to earn a PhD in neuroscience from […]
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  Venetia Zachariou

  Professor and Edward Avedisian Chair of Pharmacology, Physiology & Biophysics

  Our research focuses on signal transduction and epigenetic mechanisms underlying CNS disorders and their treatment. We use advanced genetic mouse models, viral mediated gene transfer and multidisciplinary approaches to understand the network and cell type-specific mechanisms of chronic pain, addiction, stress, and depression. Current projects investigate the mechanism by which signal transduction complexes modulate drug […]
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  Ella Zeldich

  Assistant Professor, Anatomy & Neurobiology

  Our lab is focusing on studying the cellular and molecular machinery mediating the connection between Down Syndrome and Alzheimer’s disease. We are utilizing 2D and 3D cellular models derived from human induced pluripotent stem (iPS) cells to investigate molecular mechanisms leading to neurodegeneration and demyelination in Alzheimer’s disease, ischemic stroke, and aging. Using iPS cells, […]