Przytycki Lab Awarded for Project on “Spatial Transcriptomics in Pediatric Human LAMA2 Skeletal Muscle”
The LAMA2 Association in France has awarded $28,982 to Pawel Przytycki, assistant professor in the Faculty of Computing & Data Sciences (CDS) and a core faculty member in Bioinformatics, in support of his pilot project entitled “Spatial Transcriptomics in Pediatric Human LAMA2 Skeletal Muscle” in collaboration with Ruben Dries, assistant professor at the Boston University Chobanian & Avedisian School of Medicine and Clara Gontijo Camelo, pediatric neurologist at the University of São Paulo. The project aims to understand the disruptions caused by mutations in the LAMA2 gene that result in LAMA2 congenital muscular dystrophy (CMD), an ultra-rare muscle disease that leads to loss of ambulation, contractures, and muscle weakness. The project will generate a spatial transcriptomics atlas of age-matched healthy and diseased samples to characterize LAMA2 CMD-related changes in muscle; it will then develop computational methods to identify biomarkers and build a catalog of putative therapeutic targets that will serve as resources for the community.
A press release from the LAMA2 Association about the two projects they funded this cycle is posted here: https://www.lama2.fr/nos-projets