Biology

• CAS BI 552: Molecular Biology 1
  Undergraduate Prerequisites: (CASBI203 or CASBI213) and (CASBI206 or CASBI216). - Synthesis, structure, function, regulation of macromolecules (DNA, RNA, protein). Prokaryotic and eukaryotic molecular biology. Topics include: replication, repair, recombination, transcription, translation, 5-methylcytosine, transcription factors, DNA looping (enhancer- promoter, insulator, etc.), histone modification/chromatin remodeling, non-coding RNA. Discussion of genetic and recombinant DNA techniques, including CRISPR/Cas9.
• CAS BI 553: Molecular Biology 2
  Undergraduate Prerequisites: (CASBI552) (CAS BI/CH 421/422 recommended.) - This course focuses on eukaryotic gene regulation. Course topics include genome organization and DNA rearrangement, RNA interference and noncoding RNAs, gene editing, mouse transgenic approaches, signal transduction pathways, chromatin structure, and cell cycle. Research articles will be discussed.
• CAS BI 556: Drug Discovery in Neuroscience
  Undergraduate Prerequisites: CASNE 102 (or BI 108), CH 102, and NE/PS 333. - The process of drug discovery is complex especially when a drug is intended to treat a neurological disease. This discussion-heavy course examines the specific challenges of modern neuroscience drug discovery, including: target selection, pharmacokinetics, pharmacodynamics, modeling of disease states within the context of the drivers and limitations of the Drug Discovery Industry. Effective Fall 2021, this course fulfills a single unit in each of the following BU Hub areas: Digital/Multimedia Expression, Scientific Inquiry II, Creativity/Innovation.
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  • Creativity/Innovation
  • Digital/Multimedia Expression
  • Scientific Inquiry II
• CAS BI 558: Coastal Biogeochemistry
  Undergraduate Prerequisites: (CASCH101 & CASCH102 & CASES144) or equivalents, and admission to the Marine Semester. - Examines coastal energy flow and nutrient cycling in the context of human impacts. Links between local and global scales are emphasized. Course is part of the Marine Semester and involves field and laboratory work. Also offered as CAS ES 558. Effective Fall 2019, this course is part of a Hub sequence.
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  • Part of a Hub sequence
• CAS BI 559: Quantitative Microbiology
  Undergraduate Prerequisites: (CASBI108 & CASMA121 & CASPY105) or equivalents; or consent of instructor. - Covers mathematical models used to describe bacterial behaviors and phenomena including growth, multispecies interactions, motility, and cell differentiation. Includes an introduction to python (no programming experience needed). Techniques/approaches learned are applicable to any area of the life sciences.
• CAS BI 560: Systems Biology
  Undergraduate Prerequisites: (CASBI552) or consent of the instructor. - Examines critical components of systems biology, including design principles of biological systems (e.g., feedback, synergy, cooperativity), and the generation and analysis of large-scale datasets (e.g., protein- protein interaction, mRNA expression).
• CAS BI 561: Proteostasis in the Biology of Neurodegenerative Diseases
  Undergraduate Prerequisites: CASNE 102 or CASBI 108. CASBI 203 or CASBI 213 are recommended. - A hands-on class focusing on the mechanisms that control protein homeostasis, and on the approaches that we can use to study how it may change in conditions associated with neurodegenerative diseases. The class mimics, as much as possible, a real research environment, as students carry out experiments throughout the semester, learn how to develop and test new hypotheses, and also share knowledge through weekly readings and presentation of research articles inherent to the topics of the class. Effective Fall 2021, this course fulfills a single unit in each of the following BU Hub areas: Scientific Inquiry II, Creativity/Innovation, Research and Information Literacy.
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  • Creativity/Innovation
  • Research and Information Literacy
  • Scientific Inquiry II
• CAS BI 565: Functional Genomics
  Undergraduate Prerequisites: (CASBI552) or consent of instructor. First Year Writing Seminar (e.g., WR 100 or WR 120) - Graduate Prerequisites: background in molecular biology. - This paper- and problem-based course focuses on functional genomics topics such as genetic variation, genome organization, and mechanisms of transcriptional and post-transcriptional gene regulation. Up-to-date methods include NGS, genome editing, ChIP-seq, chromatin accessibility assays, transcriptomics, and proteomics. Effective Fall 2020, this course fulfills a single unit in each of the following BU Hub areas: Oral and/or Signed Communication, Writing-Intensive Course, Critical Thinking.
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  • Critical Thinking
  • Oral and/or Signed Communication
  • Writing-Intensive Course
• CAS BI 566: DNA Dynamics in Disease
  Undergraduate Prerequisites: (CASBI206 OR CASBI216) or consent of instructor. - What goes wrong to cause disease? In this course we examine diseases caused by problems in basic cellular processes including mitosis, meiosis, and DNA repair. We focus on past and current research that has led to the understanding of the mechanisms contributing to disease. Content is delivered through active, engaging lectures where you analyze data from past and current research papers, and think critically to answer questions. Paper discussion days include an in- depth analysis of one primary literature article that is central to the field. Effective Fall 2022, this course fulfills a single unit in each of the following BU Hub areas: Scientific Inquiry II, Critical Thinking, Research and Information Literacy.
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  • Critical Thinking
  • Research and Information Literacy
  • Scientific Inquiry II
• CAS BI 569: Tropical Marine Invertebrates
  Undergraduate Prerequisites: (CASBI107 & CASBI260) and enrollment in the Marine Semester. - Explores the diversity of marine invertebrates, including body plans, feeding biology, reproductive strategies, and developmental programs. Field biodiversity surveys and behavioral studies in shallow water tropical marine environments, especially seagrass beds and mangrove.
• CAS BI 572: Advanced Genetics
  Undergraduate Prerequisites: (CASBI206 & CASBI203) CAS BI 552 is recommended. - An in-depth study of eukaryotic genetics, ranging from the history and basic principles to current topics and modern experimental approaches. Genetics of Drosophila, C. elegans, mice, and humans are explored in detail, including readings from primary literature. Three hours lecture, one hour discussion. Effective Fall 2023, this course fulfills a single unit in each of the following BU Hub areas: Oral and/or Signed Communication, Ethical Reasoning.
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  • Ethical Reasoning
  • Oral and/or Signed Communication
• CAS BI 576: Carcinogenesis
  Undergraduate Prerequisites: (CASBI203 & CASBI206 & CASBI552) - Covers multiple aspects of cancer biology with a focus on molecular mechanisms underlying cancer development and progression, and the implications for therapy. Topics include oncogenes, tumor suppressors, apoptosis, angiogenesis, metastasis, mouse models, and chemotherapy. Emphasis on current research. Students may not receive credit for more than one of the following courses: CAS BI 327, CAS BI 576, and GMS BT 520.
• CAS BI 577: Quantitative Approaches in Molecular Biology
  Undergraduate Prerequisites: (GRSBI753) and PhD standing. - Introduces biology graduate students to concepts and bioinformatics tools necessary for quantitative analysis of biological problems. Students learn the programming language R, analyze next generation sequencing and transcriptomic data.
• CAS BI 578: Marine Geographic Information Science
  Undergraduate Prerequisites: (CASBI260 & CASES144) CASMA213 strongly recommended. Enrollment in the Marine semester requ ired. - Introduction to marine geographic information systems and spatial analysis for conservation, management, and marine landscape ecology. Comparative examples from Gulf of Maine and tropics. Solve problems in coastal zoning and marine park design, whale and coral reef conservation. Also offered as CAS EE 578.
• CAS BI 579: Progress in Ecology, Behavior, Evolution, and Marine Biology 1
  Undergraduate Prerequisites: graduate standing in EBE or MB. - Facilitates presentation and discussion of research ideas, preliminary data, and research progress by all graduate students in Ecology/Behavior/Evolution and Marine Biology (EBE-MB). All EBE-MB graduate students are encouraged to participate every semester, but only receive two credits toward the degree once, for BI 579 or BI 580. Not a Biology/BMB major/minor elective toward the BA and cannot be combined with another 2-credit course for elective credit toward the BA.
• CAS BI 580: Progress in Ecology, Behavior, Evolution, and Marine Biology 2
  Undergraduate Prerequisites: graduate standing in EBE or MB. - Facilitates presentation and discussion of research ideas, preliminary data, and research progress by all graduate students in Ecology/Behavior/Evolution and Marine Biology (EBE-MB). All EBE-MB graduate students are encouraged to participate every semester, but only receive two credits toward the degree once, for BI 579 or BI 580. Not a Biology/BMB major/minor elective toward the BA and cannot be combined with another 2-credit course for elective credit toward the BA.
• CAS BI 581: Seminar in Biology
  Undergraduate Prerequisites: consent of instructor. - Graduate Prerequisites: consent of instructor. - Informal discussion and student reports on subjects of current interest based on an intensive study of the literature. Topics and prerequisites vary. Not for Biology major or minor credit unless two sections of BI 581/582 are taken. One topic is offered Fall 2021. Section B1: Grant Writing. Seminar course in preparing a research grant proposal.
• CAS BI 582: Seminar in Biology
  Undergraduate Prerequisites: consent of instructor. - Graduate Prerequisites: consent of instructor. Open to seniors and graduate students concentra ting in biology. - Informal discussion and student reports on subjects of current interest based on an intensive study of the literature. Topics and prerequisites vary. Not for Biology major or minor credit unless two sections of BI 581/582 are taken. Topic for Spring 2022, Section Z1: Professional Development for Biology PhDs (Pre- reqs: PhD standing; completion of qualifying exams). Explores topics related to a variety of career paths post-PhD. Topics may include Individual Development Plans (IDPs), career panels for industry, non-profit, or government jobs, oral/written presentation skills, and will be shaped by the preferences of students in the class.
• CAS BI 583: Seminar: Progress in Cell and Molecular Biology
  Undergraduate Prerequisites: Open to graduate students only. - Facilitates presentation and discussion of research ideas, preliminary data, and research progress by all graduate students in Cell & Molecular Biology (CM). All CM graduate students are encouraged to participate every semester, but receive credits toward the degree only once. BI 583 (fall course) and BI 584 (spring course) can both be taken (4 credits total) for the degree.
• CAS BI 584: Seminar: Progress in Cell and Molecular Biology
  Undergraduate Prerequisites: Open to graduate students only. - Facilitates presentation and discussion of research ideas, preliminary data, and research progress by all graduate students in Cell & Molecular Biology (CM). All CM graduate students are encouraged to participate every semester, but receive credits toward the degree only once. BI 583 (fall course) and BI 584 (spring course) can both be taken (4 credits total) for the degree.