Faculty News
Lynne Chantranupong Receives 2025 Sloan Research Fellowship
Dr. Lynne Chantranupong recently received the 2025 Sloan Research Fellowship. The Alfred P. Sloan Foundation recognizes standout young scientists whose work is promising and innovative. The winners each receive $75,000 over two years.
When Dr. Chantranupong joined the BU's faculty in January 2024, she launched multiple research projects to investigate cellular mechanisms in the brain. One of her focuses is elucidating how a specialized part of the cell, called the lysosome, gets rid of waste, and how this waste differs across neurons.
She recently started collaborating with Dr. Ji-Xin Cheng to image the contents of a single lysosome at higher resolutions. The Sloan Foundation award will support their collaboration and bolster Dr. Chantranupong’s ongoing research projects.
Read the full announcement here.
Congratulations, Dr. Chantranupong!
Five MCBB Faculty Receive 2024 Rajen Kilachand Fund for Integrated Life Sciences & Engineering Awards
Five MCBB Faculty are part of three groups to win 2024 Rajen Kilachand Fund for Integrated Life Sciences & Engineering Awards. The Fund, launched in 2017, has awarded $14 million to support projects that have advanced science, built collaborative structures for interdisciplinary research, and expanded funding opportunities. Learn about their projects below.
Dr. Wilson Wong and Dr. Florian Douam (BU School of Medicine), along with Dr. Alexander Green, Dr. Mark Grinstaff (BU College of Engineering), and Dr. Ahmad Khalil hope to to pioneer a new tool for fighting future pandemics.
About a year ago, Dr. Wong and Dr. Grinstaff discovered a novel way to modify saRNA, a breakthrough they’ve since used to create a more effective COVID-19 vaccine in collaboration with Dr. Douam. Combining this breakthrough with Dr. Khalil’s nanobody discovery platform and computational tools designed by Dr. Green, the team aims to create scalable, cost-effective, and rapidly deployable solutions for viral prevention and treatment.
Dr. Wong is leading the project with Dr. Douam; Dr. Green, Dr. Grinstaff, and Dr. Khalil are coinvestigators.
Dr. Joe Larkin and Dr. Mary Dunlop, along with Dr. Douglas Holmes and Dr. Harold Park, are leading innovative efforts to address the urgent global challenge of antibiotic resistance. Antibiotic resistance poses a serious global health threat, with bacteria evolving faster than new drugs can be developed.
The team's project focuses on horizontal gene transfer and the single-cell level events that are involved in making an individual bacterium transition from being drug-susceptible to drug-resistant. Using optogenetics, they aim to trigger and observe this process in real time, offering novel insights into how bacteria transition from drug-susceptible to drug-resistant. Their innovative work could lead to groundbreaking strategies to combat the spread of antibiotic resistance.
Read the full announcement here.
Congratulations, everyone!
Dr. Alexander Green Receives 2024 National Institutes of Health Director’s Transformative Research Award
Dr. Alexander Green, an Associate Professor for Biomedical Engineering in the Green Lab, received the 2024 National Institutes of Health Director’s Transformative Research Award.
The Transformative Research Award focuses on significance and innovativeness where the proposed project must address a significant problem and be bold, highly innovative, and transformative. The proposal must be high-risk, high-reward, and would not be funded through a conventional NIH funding mechanism. Lastly, the application will be anonymized to be reviewed by the NIH staff.
In Green's research, he hopes that by tracking the forces involved when cells interact with one another, like in cell-based cancer therapies, he can better control their behavior and pave the way for more potent disease treatments. It’s an out-there, novel idea—and it could fizzle or it could change lives. But Green’s chances of success have just been given a major boost.
Green is sharing the award’s $7.2 million funding with two researchers from Yale University, Julien Berro, and Xiaolei Su, and he says their proposed cell forces project would typically be a tough one to win backing for—all promise with, so far, little proof that it’ll work.
Green is just the third BU researcher to be given the honor, behind Bela Suki, an ENG professor of biomedical engineering, and Steve Ramirez (CAS’10), a College of Arts & Sciences associate professor of psychological and brain sciences.
Read more here.
Congratulations Dr. Alexander Green!
Dr. Brian Cleary Receives Career Development Professorship
Excerpt from The Brink "Career Development Professorships Awarded to Five BU Researchers"
They’re scholars of Latin American literature and Asian history, experts in biomedical engineering and computing, organic chemistry, and biology—and now, five rising star Boston University faculty are also winners of prestigious Career Development Professorships. The high-caliber awards, given annually by BU’s Office of the Provost, recognizes “talented junior educators emerging as future leaders within their respective fields.”
The professorships provide stipends for the recipients’ salaries and research for the next three years. The awards are named in honor of the donors and alumni who fund them, with winners nominated by their respective deans and selected by the provost’s office.
“Our current cohort of Career Development Professors are incredibly impressive both in terms of the breadth of their work and the impact they have already had on their fields. They bring energy, exciting new ideas, and fresh approaches to their research and teaching,” says Gloria Waters, University provost and chief academic officer. “We are grateful to our generous donors and alumni for their support and shared belief in the promise these rising colleagues present.”
This year’s Career Development Professors are:
Shibulal Family Career Development Professorship, established by BU Trustee S. D. Shibulal (MET’88)
Brian Cleary, a Faculty of Computing & Data Sciences assistant professor, who holds appointments in biology and biomedical engineering, investigates the nature of molecular, cellular, and tissue processes by integrating computational and algorithmic tools into biology research. Called “a deep thinker and fearless leader-in-the-making,” by his nominator, Azer Bestavros, a William Fairfield Warren Distinguished Professor of Computer Science and associate provost for BU’s Faculty of Computing & Data Sciences, Cleary “truly embraces the integrative, cross-cutting culture of CDS and embodies the qualities needed to be a leading innovator in data science.”
Read more here.
Congratulations Dr. Brian Cleary!
Dr. Mary Dunlop Receives New BU Postdoctoral Awards Excellence in Mentorship and Research
Excerpt from The Brink "New BU Postdoctoral Awards Celebrate Excellence in Mentorship and Research"
When postdoctoral researcher Jean-Baptiste Lugagne began applying to faculty positions last year, he steeled himself for a daunting process. In an intensely competitive job market, university search committees seek candidates who can demonstrate vast skill sets beyond their field-specific expertise, from teaching to grant writing to lab management.
But Lugagne had a secret weapon to help him through the job search: his faculty mentor, Mary Dunlop. A Boston University College of Engineering associate professor of biomedical engineering, Dunlop guided Lugagne in refining his research proposal, gave him feedback on his interview materials, and even helped him organize a practice “chalk talk” with other faculty to ensure he was prepared for his presentations to search committees. The preparation paid off: Lugagne is joining the University of Oxford as an assistant professor of engineering science next year.
Now, in recognition of her deep commitment to the professional and personal development of postdoctoral researchers at BU, Dunlop has been awarded the University’s first-ever Award for Excellence in Mentoring Postdocs. She was honored at BU’s National Postdoc Appreciation celebration.
“These awards reflect the critical contributions of our postdocs and their mentors,” says Pallavi Eswara, director of postdoctoral affairs at BU. “Our postdocs are doing excellent research, but they are also contributing to our research community in countless other ways, as teachers, mentors, DEI leaders, and innovators.”
Read more here.
Congratulations Dr. Mary Dunlop!
Michelle Teplensky Receives Beckman Young Investigator Award
Dr. Michelle Teplensky was recently named one of the 2024 Beckman Young Investigators. She and her team will receive $600,000 over four years to engineer versatile vaccine responses through nanomaterial design, with implications for the treatment of not only the flu but also other infectious diseases including the viruses that cause COVID-19, HIV, and more.
The Beckman Young Investigator (BYI) Program provides research support to the most promising young faculty members in the early stages of their academic careers in the chemical and life sciences, particularly to foster the invention of methods, instruments and materials that will open up new avenues of research in science.
Read a detailed announcement here.
Congratulations, Dr. Michelle Teplensky!
Green Lab Publishes Patent for Detecting Nucleic Acids
Milad Babaei, MCBB PhD student of the Green Lab, and Dr. Zhaoqing Yan (GRS '23), along with their mentor, Dr. Alexander Green, are co-authors on a recently published patent. This patent, titled "Isothermal Nucleic Acid Detection Assays and Uses Thereof" by Green et al. (US Patent 2023/0313283, October 2, 2023), describes rapid methods for detecting nucleic acids, from viruses to circulating mRNAs, in low-cost portable formats.
Nucleic acids, such as DNA and RNA, play a crucial role in genetic information. "Isothermal" refers to processes that occur at a constant temperature. In the context of nucleic acid detection, isothermal assays are methods that allow the amplification and detection of nucleic acids at a constant temperature without the need for thermal cycling, as in PCR (Polymerase Chain Reaction).
The team is currently expanding its panel of detection by developing lateral flow strips that can spontaneously probe for multiple targets using multiple test lines. This capability is crucial for the future of detecting and analyzing nucleic acids, which are fundamental in various fields, including medical diagnostics, research, and biotechnology.
Congratulations, Dr. Alexander Green, Milad Babaei, and Dr. Zhaoqing Yan!
Michelle Teplensky Named AIChE’s 35 Under 35
Dr. Michelle Teplensky was recently named 2023 AIChE's (American Institute of Chemical Engineers) 35 under 35. AIChE honors 35 chemical engineering professionals who have mad great contributions to the field in seven categories, bioengineering, chemicals and materials, education and outreach, energy and environment, innovation and entrepreneurship, leadership. and safety. Teplensky was recognized under the bioengineering category.
Teplensky and her research group focuses on engineering nanotechnology to control immunological cell connectivity, processing, and communication by design. In doing so, they elucidate fundamentals about cellular events and leverage this knowledge to develop improved therapeutics and vaccines that can impact the treatment of cancer and infectious disease. Their work is highly interdisciplinary, and bridges the fields of engineering, chemistry, nanotechnology, immunology, and biomaterials. By sitting at this interface, we are able to develop and incorporate synthetic nanoscale advances to control immunological activity and elucidate design rules that have widespread impacts on therapeutic development. She hopes that the students trained in her lab enter their careers feeling inspired.
Teplensky loves to shop at Stew Leonard’s, and she has become an avid fan of Boston Univ.’s hockey team. Her family has a tradition of buying and completing a puzzle on every vacation.
Congratulations, Michelle Teplensky!
Alexander Green on Saliva Test for Soldiers, Athletes, and Others Aims to Predict Performance
Dr. Alexander Green, BU's Associate Professor in Biomedical Engineering, and his colleagues plan to develop a fast, portable saliva test that will analyze an assortment of biomarkers associated with performance on challenging tasks. This project is funded by the US Defense Projects Agency (DARPA), which aims to develop a test that will one day save lives and dollars by predicting soldiers' performance on missions.
With funding up to $17.7 million federal funds, Green and his team will start by testing volunteers as they undergo precise physiological tests. For example, the volunteers might be intensely exercising for multiple days with little rest, while the team will take samples to see how their performance might be associated with different biomarkers, such as testosterone, cortisol, and myoglobin.
Though this research will be a complex challenge, Green's long experience in developing paper-based testing systems will guide him through this research journey. You can read more about it here.
Congratulations, Dr. Alexander Green!
Daniel Segrè and Melisa Osborne Featured in The Brink
Dr. Daniel Segrè and Dr. Melisa Osborne were recently featured in The Brink for their article "Non-additive microbial community responses to environmental complexity," which was published in nature communications this spring. An excerpt of The Brink article is below:
There’s a lot of interest right now in how different microbiomes—like the one made up of all the bacteria in our guts—could be harnessed to boost human health and cure disease. But Daniel Segrè has set his sights on a much more ambitious vision for how the microbiome could be manipulated for good: “To help sustain our planet, not just our own health.”
Segrè, director of the Boston University Microbiome Initiative, says he and other scientists in his field of synthetic and systems biology are studying microbiomes—microscopic communities of bacteria, fungi, or a combination of those that exert influence over each other and the surrounding environment. They want to know how microbiomes might be directed to carry out important tasks like absorbing more atmospheric carbon, protecting coral reefs from ocean acidification, improving the fertility and yield of agricultural lands, and supporting the growth of forests and other plants despite changing environmental conditions.
Read the full article here.