Jen-Wei Lin
My main research focus is on the biophysical events underlying transmitter release. Neurotransmitter secretion involves ion channel gating, diffusion and buffering of calcium ions, vesicular fusion as well as the mobilization and recycling of, synaptic vesicles. We use electrophysiological and imaging techniques to monitor processes underlying synaptic transmission at a high time resolution. Using the […]
Jennifer Luebke
Prof. Luebke maintains a laboratory in which whole-cell patch-clamp and intracellular filling techniques are used to examine the electrophysiological and morphological properties of neurons in in vitro slices of monkey and transgenic mouse neocortex. Research is focused on action potential firing patterns (and underlying ionic currents), glutamatergic and GABAergic synaptic response properties and detailed dendritic […]
Heng-Ye Man
Our research interests are focused on brain development, especially neuronal migration, morphogenesis, synapse formation, glutamate receptors and synaptic plasticity. We aim to understand the cellular and molecular processes implicated in neurodegenerative diseases and developmental disorders including autism, Angelman syndrome, intellectual disability and Alzheimer’s disease. We use diverse techniques including biochemistry, immunofluorescent staining, live imaging, virus […]
Maria Medalla
Prof. Medalla received her Ph.D. in Applied Anatomy and Physiology at the Boston University Department of Health Sciences in 2008, working with Prof. Helen Barbas to study the structure of ‘cognitive control’ pathways in the prefrontal cortex (PFC) of non-human primates. Her studies in this lab were the first to utilize triple-labeling methods for electron […]
Gabriel Ocker
I work in theoretical neuroscience, studying structure-function relations in neuronal network models. How does neural activity encode sensory information and drive behavior? How do neural circuits evolve, learn, and adapt to shape that activity? How does that connectivity shape activity, and what computations does that activity perform? My group studies models of neural circuits, often […]
Steve Ramirez
The mission of my lab is twofold: to reveal the neural circuit mechanisms of memory storage and retrieval, and to artificially modulate memories to combat maladaptive states. We will do so in a multi-disciplinary fashion by combining virus engineering strategies, immunohistochemistry and physiology, optogenetics and functional imaging of targeted populations in vivo, and a battery […]
Douglas Rosene
Prof. Rosene is recognized as one of the world’s experts on the anatomy of the temporal lobe limbic system and has published extensively in this area. He is also recognized for his work in the neurobiology of cognitive aging and was Program Director for 15 years of a long-standing NIH Program Project studying the neural […]
Jean-Pierre Roussarie
The Roussarie lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. Dr. Roussarie thinks that understanding the particularities […]
Shelley Russek
The Russek Laboratory’s chief interests surround a desire to understand how the dynamic regulation of neurotransmitter receptors in the brain shapes the development of the nervous system and how the re-establishment of developmental processes in the adult brain can precipitate neurologic and neuropsychiatric diseases. The identification of gene families with multiple genes that code for […]
Jean-Jacques Soghomonian
Prof. Soghomonian directs the Laboratory for the Cellular Biology of the Basal Ganglia. The laboratory currently focuses on neurotransmitter imbalances in the basal ganglia and their contribution to movement, learning, and cognitive disorders. The laboratory uses a combination of anatomical, neurochemical and molecular biology techniques.