Robert Stern
A major focus of Prof. Robert Stern’s research involves the long-term effects of repetitive brain trauma in athletes, including the neurodegenerative disease, CTE. He has funding from NIH and the Department of Defense for his work on developing methods of detecting and diagnosing CTE during life, as well as examining potential genetic and other risk […]
Helen Tager-Flusberg
The overall aims of the research conducted in our center address questions about the phenotypic characteristics of the language, communication, and associated social-cognitive deficits in autism (ASD) and other neurodevelopmental disorders. We have three ongoing lines of research: 1) investigating the early behavioral and brain developmental trajectories in infants at risk for autism (in collaboration […]
Tuan Leng Tay
How do the different types of glial cells, such as astrocytes and microglia, support the healthy development of the brain? They are important in the maintenance and (immune) protection of our nervous system. In disease and injury, glial cells alter themselves in response to a disrupted steady state, potentially to restore health to their neuronal […]
Julia TCW
Prof. TCW is interested in understanding Alzheimer’s disease. Her research is focused on a mutant form of Apolipoprotein E (APOE), a major genetic risk factor for Alzheimer’s disease. These studies will provide an opportunity to evaluate the APOE genetic contribution to neurodegeneration associated with the disease by using brain cells derived from human induced pluripotent […]
Michael Wallace
The Wallace lab studies how specific circuits within the basal ganglia (BG) guide motivated behaviors, control goal-directed motor actions, and how these circuits are affected in disease. The lab has expertise in electrophysiology, molecular biology, genetics, in vivo optogenetics, computer programming, and in behavioral and imaging techniques. We apply these techniques and knowledge of BG […]
Benjamin Wolozin
The goal of our research is to understand the mechanisms underlying neurodegenerative diseases, and then to use this understanding to develop novel interventions for disease. Much of our research focuses on the central concept of regulated protein aggregation. Protein aggregation in neurodegenerative diseases is classically thought to occur as an unwanted byproduct of protein misfolding. […]
Venetia Zachariou
Our research focuses on signal transduction and epigenetic mechanisms underlying CNS disorders and their treatment. We use advanced genetic mouse models, viral mediated gene transfer and multidisciplinary approaches to understand the network and cell type-specific mechanisms of chronic pain, addiction, stress, and depression. Current projects investigate the mechanism by which signal transduction complexes modulate drug […]
Ella Zeldich
Our lab is focusing on studying the cellular and molecular machinery mediating the connection between Down Syndrome and Alzheimer’s disease. We are utilizing 2D and 3D cellular models derived from human induced pluripotent stem (iPS) cells to investigate molecular mechanisms leading to neurodegeneration and demyelination in Alzheimer’s disease, ischemic stroke, and aging. Using iPS cells, […]
Basilis Zikopoulos
Our research focuses on the study of the organization and dynamics of cortical brain circuits, and their disruption in disease. We use experimental and theoretical (computational) approaches to study molecular, synaptic, cellular interactions and interareal network connectivity, as the basis of cognitive and emotional processing for flexible attention and goal-oriented behavior.
Jennifer Zuk
Jennifer Zuk studies factors in early childhood that shape the trajectory of speech, language, and reading acquisition, with the aim to facilitate positive outcomes for children susceptible to neurodevelopmental disabilities. Her research employs behavioral and neuroimaging tools with children from infancy through school age to study associations between the brain and speech, language, and reading […]