Joshua Campbell

Joshua D. Campbell is an Associate Professor in the Department of Medicine and the Faculty of Computing & Data Sciences. He also serves as the director of the Bioinformatics Program and the co-scientific director of the Boston University Medical Campus Single Cell Sequencing core. His interdisciplinary research lies at the intersection of data science and translational medicine, with a focus on understanding human diseases such as cancer.

Previously, Dr. Campbell was a postdoctoral fellow at the Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT. In the lab of Dr. Matthew Meyerson, he performed comprehensive genomic characterization of lung cancers in The Cancer Genome Atlas (TCGA) consortium and investigated differences in somatic mutations across ancestral groups. In 2016, he joined the faculty in the Section of Computational Biomedicine within the Department of Medicine at Boston University’s Chobanian & Avedisian School of Medicine.

Currently, his lab develops novel Bayesian methods and software for analyzing diverse biological data, including single-cell and spatial omics data, as well as mutational signatures in cancer. In collaboration with clinical and experimental colleagues, his group also conducts translational research, generating novel multi-omic datasets from patient samples at Boston Medical Center (BMC) to drive new discoveries.

Research Interests

• Developing interpretable Bayesian factorization methods for biological data
• Novel methods for single-cell and spatial transcriptomic deconvolution.
• Novel methods for multi-modal deconvolution of mutational signatures in cancer.
• Molecular alterations that drive premalignant, invasive, and metastatic states in lung cancer.
• Biological factors and social determinants of health (SDoH) that contribute to clinical disparities in prostate cancer.

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