MSE PhD Final Defense: Neila Gross

MSE PhD Final Defense: Neila Gross

TITLE: Understanding Anthropological Effects On Pathogenic Multidrug Resistance In Vulnerable Populations

ADVISOR: Muhammad Zaman (BME, MSE)

CHAIR: Joerg Werner (ME, MSE)

COMMITTEE: Erinda Lika Pharmacology, University of Albania Tirana, Ellen Cooepr BMC Med Campus, Devin Bowes University of South Carolina

ABSTRACT: As global conflict continues to surge, the accumulation of environmental toxins in various ecosystems, including wastewater, has raised concerns about their role as vectors for antimicrobial resistance, particularly in low- and middle-income countries (LMICs). This dissertation explores the intricate relationship between environmental contaminants—specifically microplastics, heavy metals, and subinhibitory antibiotic concentrations—and multidrug resistance (MDR) development within microbial populations. Here, the focus is on refugee camps, informal settlements, and other vulnerable settings where the convergence of high infection rates, inadequate waste management, and limited access to healthcare exacerbates the risk of antimicrobial resistance. By modeling the interactions between microplastics, metals, and antibiotics in these environments, the research seeks to fill critical knowledge gaps regarding the environmental factors driving multidrug resistance and to advance ethical frameworks for conducting research in marginalized communities. Ultimately, the findings will contribute to a deeper understanding of how environmental pollutants facilitate the spread of multidrug-resistant bacteria, informing both clinical and environmental management strategies to mitigate this global health crisis.