Table 2a
Table 2a: Proteasome and proteases inhibitors that inhibit Rel/NF-kB
| Molecule | References |
| Proteasome inhibitors | |
| Peptide Aldehydes: | Palombella et al, 1994; Grisham et al, 1999; Jobin et al, 1998 |
| ALLnL
(N-acetyl-leucinyl-leucynil-norleucynal, MG101) |
|
| LLM (N-acetyl-leucinyl-leucynil-methional) | |
| Z-LLnV
(carbobenzoxyl-leucinyl-leucynil-norvalinal,MG115) |
|
| Z-LLL
(carbobenzoxyl-leucinyl-leucynil-leucynal, MG132) |
|
| MG262 | Pujois et al, 2012 |
| Lactacystine, beta-lactone | Fenteany & Schreiber, 1998; Grisham et al, 1999 |
| Boronic Acid Peptide | Grisham et al, 1999; Iqbal et al, 1995 |
| Dithiocarbamate complexes with metals | Cvek & Dvorak, 2007 |
| CEP-18770 | Piva et al, 2007 |
| Ubiquitin Ligase Inhibitors | Yaron et al, 1997 |
| PS-341 (Bortezomib) | Adams, 2004 |
| Salinosporamide A (1, NPI-0052) | Macherla et al, 2005; Ahn et al, 2007 |
| Cyclosporin A | Frantz et al, 1994; Kunz et al, 1995; Marienfeld et al, 1997; McCaffrey et al, 1994;Meyer et al, 1997; Wechsler et al, 1994 |
| FK506 (Tacrolimus) | Okamoto et al, 1994; Venkataraman et al, 1995 |
| Deoxyspergualin | Tepper et al, 1995 |
| Disulfiram | Lovborg et al, 2005 |
| PT-110 | Momose et al, 2007 |
| Protease inhibitors | |
| APNE (N-acetyl-DL-phenylalanine-b-naphthylester) | Higuchi et al, 1995 |
| BTEE (N-benzoyl L-tyrosine-ethylester) | Rossi et al, 1998 |
| DCIC (3,4-dichloroisocoumarin) | D’Acquisto et al, 1998 |
| DFP (diisopropyl fluorophosphate) | |
| TPCK (N-a-tosyl-L-phenylalanine chloromethyl ketone) | |
| TLCK (N-a-tosyl-L-lysine chloromethyl ketone) | |
