| Mediator |
Reference |
| Acetaldehyde |
Hsiang et al, 2007 |
| Acrp30/adiponectin |
Tsao et al, 2003; Hattori et al, 2007; Tomizawa et al, 2008 |
| Activin A |
Sugatani et al, 2003 |
| Adenosine |
Porkka-Heiskanen et al, 2002 |
| Adiponectin |
Hug & Lodish, 2005; Haugen & Drevon, 2007 |
| Adrenomedullin |
Pleguezuelos et al, 2004; Hagi-Pavli et al, 2005 |
| AILb-A (from Aeginetia indica) |
Okamoto et al, 2004 |
| Albumin |
Drumm et al, 2002; Tang et al, 2003 |
| Alginate |
Yang & Jones, 2008 |
| Allergin |
Coward et al, 2004 |
| Alloferin |
Ryu et al, 2008 |
| Alloxan |
Zhang et al, 2003 |
| Amadori adducts |
Nevado et al, 2005 |
| Amino acid analogs |
Kretz-Remy et al, 1998 |
| Anaphylatoxin C3a and C5a |
Pan, 1998 |
| Angiotensin II (+aldossterone) |
Li & Brasier, 1996; Li et al, 2006; Guo et al, 2006 |
| Angiotensin IV |
Esteban et al, 2005 |
| Angiotensin II type 1-receptor activating antibodies |
Dragun et al, 2005 |
| Anti-CD30 antibody 5F11 |
Boll et al, 2005 |
| Antiphospholipid antibodies |
Pierangeli et al, 2004 |
| Arachidonic acid |
Ramakers et al, 2007 |
| Areca nut extract |
Lin et al, 2004 |
| Arginine vasopressin |
Fan et al, 2007 |
| Autotaxin |
Lee et al, 2006 |
| Baicalin (plant compound) |
Park et al, 2004 |
| Basic calcium phosphate crystals |
McCarthy et al, 1998 |
| Bronchoalveolar lavage fluid |
Nys et al, 2002; 2005 |
| Bradykinin |
Pan et al, 1996 |
| Brusatol |
Cuendet et al, 2004 |
| Burn patient serum |
Li et al, 2005 |
| beta-carotene |
Palozza et al, 2003 |
| Carrageenan |
Borthakur et al, 2007 |
| Catalase |
Jang et al, 2004 |
| C2-Ceramide (N-acetyl-sphingosine) |
Andrieu et al, 1995 |
| Cerulein |
Gukovsky et al, 1998; Steinle et al, 1999 |
| Chelidonium majus extract |
Chung et al, 2004 |
| Collagen lattice |
Xu et al, 1998 |
| Collagen Type I |
Lee et al, 1995 |
| Conditioned medium from macrophages |
Permana et al, 2006 |
| Corn silk |
Kim et al, 2005 |
| Cryptdins |
Lin et al, 2004 |
| Curcuma xanthorrhiza Roxb extract |
Kim et al, 2007 |
| Cystamine |
Tzang et al, 2008 |
| Cysteinyl leukotrines |
Kawano et al, 2003 |
| Deoxycholic acid (bile acid) and derivatives |
Jenkins et al, 2003; Payne et al, 2006; Hirano et al, 2006 |
| Depression/early life stress |
Pace et al, 2006 |
| Des-Arg10-kallidin (B1 receptor agonist) |
Schanstra et al, 1998 |
| 1,25-dihydroxycholecalciferol |
Adams & Teegarden, 2004 |
| Double-stranded polynucleotides |
Suzuki et al, 1999 |
| f-Met-Leu-Phe |
Browning et al, 1997 |
| Endosulfan |
Han et al, 2007 |
| Epimedium flavonoids |
Liu et al, 2006 |
| Exosomes secreted from monocytes |
Matsumoto et al, 2004 |
| Fibrinogen |
Guo et al, 2004 |
| Ferulic acid derivative |
Ronchetti et al, 2006 |
| Fenretinide |
Hewson et al, 2005 |
| Free fatty acids |
Tripathy et al, 2003 |
| Ganoderma lucidum |
Kuo et al, 2005 |
| Genistein |
Borras et al, 2006 |
| Geranylgeranylacetone |
Nishida et al, 2007 |
| Ginsenosides |
Ge et al, 2007 |
| (High) glucose |
Iwasaki et al, 2007 |
| beta-glycyrrhetinic acid |
Shaneyfelt et al, 2006 |
| Halothane |
Brasil et al, 2006 |
| Heat shock protein 25 (Hspb1) |
Yi et al, 2002 |
| Heat shock protein 60 (HSP 60) |
Kol et al, 1999 |
| Hemoglobin |
Simoni et al, 1998; Ogasawara et al, 2009 |
| Hericium erinaceum extract |
Son et al, 2006 |
| Histamine |
Tanimoto et al, 2007 |
| Homocysteine |
Mercie et al, 2000 |
| Hyaluronan |
Noble et al, 1996; Scheibner et al, 2006 |
| Hydrogen sulfide |
Zhang et al, 2007; Zhi et al, 2007 |
| 12(R)-Hydroxyeicosatrienoic acid |
Laniado-Schwartzman et al, 1994 |
| 20-Hydroxyeicosatrienoic acid |
Ishizuka et al, 2007 |
| 6-Hydroxydopamine |
Park et al, 2004 |
| hPepT1 (apical di-/tripeptide transporter |
Vavricka et al, 2004 |
| Kainic acid (Kainate) |
Kaltschmidt et al, 1995; Lubin et al, 2005 |
| Lactate |
Miller et al, 2007 |
| Laminin |
Armstrong et al, 2008 |
| Leukotriene B4 |
Brach et al, 1992; Huang et al, 2004 |
| L-Glutamate |
Guerrini et al, 1995 |
| Lipid ozonation products |
Kafoury et al, 2007 |
| Long-term potentiation (LTP) |
Freudenthal et al, 2004 |
| Lysophosphatidylcholine (LysoPC) |
Zhu et al, 1997; Ryborg et al, 2005 |
| alpha-mangostin |
Shaneyfelt et al, 2006 |
| Melanin (from plants) |
Pugh et al, 2005 |
| Mixed meal ingestion (high glucose) |
Aljada et al, 2004; Schiekofer et al, 2006 |
| Monosodium urate crystals |
Jaramillo et al, 2004 |
| Monocrotaline (plant toxin) |
Iwasaki et al, 2005 |
| Neuromelanin |
Wilms et al, 2003 |
| Neurotensin |
Zhao et al., 2005 |
| Neutrophil elastase |
Walsh et al, 2001 |
| Nitric oxide |
Hemish et al, 2003 |
| NSAIDS (sulindac, sulindac sulfone, indomethacin) |
Loveridge et al, 2007 |
| NS-398 (high dose) |
Moalic-Juge et al, 2002 |
| Nucleotide activation of P2 receptors |
Korcok et al, 2005 |
| Oleic acid |
Park et al, 2003 |
| Optunia polyacantha (prickly pear) polysaccharides |
Schepetkin et al, 2008 |
| Osteopontin |
Philip et al, 2001; Philip & Kundu, 2003 |
| PAF (platelet activating factor) |
Smith & Shearer, 1994; Mutoh et al, 1994 |
| Palmitate |
Cacicedo et al, 2004; Ajuwon & Spurlock, 2005; Xu et al, 2007; Laine et al, 2007; Ishikado et al, 2009 |
| PCSC (polysaccharide from Poria cocos) |
Lee et al, 2004 |
| Phellinus linteus proteoglycan |
Kim et al, 2004 |
| Pingyangmycin |
Wu et al, 2006 |
| Plaunotol |
Fu et al, 2005 |
| Platelet type arachidonate 12-lipoxygenase |
Kandouz et al, 2003 |
| Polysaccharides of Poria cocos |
Lee & Jeon, 2003 |
| Polysaccharides of Astragalus membranaceus |
Lee & Jeon, 2005 |
| Potassium |
Kaltschmidt et al, 1995 |
| Prolacting and Prolactin N-terminal fragment (16K PRL) |
Macotela et al, 2002′; Boutet et al, 2007; Tabruyn et al, 2007 |
| Proteolysis-inducing factor (PIF) |
Watchorn et al, 2002 |
| Rapamycin |
Dichtl et al, 2005 |
| Regulatory RNA |
Watanabe et al, 2003 |
| Rev-erbalpha |
Migita et al, 2004 |
| Rhodiola rhizome aqueous extract |
Mishra et al, 2006 |
| S100B |
Kogel et al, 2004 |
| Salsolinol |
Wanpen et al, 2007 |
| Saturated fatty acids |
Lee et al, 2003 |
| Scopoletin (6-methoxy-7-hydroxycoumarin) |
Kim et al, 2005 |
| Serum amyloid A |
Jijon et al, 2005 |
| Solanum nigrum |
An et al, 2005 |
| St John’s Wort (hyperforin) |
Zhou et al, 2004 |
| Streptozotocin |
Choi et al, 2002 |
| Substance P |
Guo et al, 2002 |
| Tansy floret polysaccharides |
Xie et al, 2007 |
| Tauroursodeoxycholic acid (TUDCA) |
Rodrigues et al, 2003; Toledo et al, 2004 |
| T-cell costimulatory receptor 4-1BB |
Lee et al, 2002 |
| Thioredoxin |
Hirota et al, 1999 |
| Tetrandine |
Liou et al, 2008 |
| Thrombin |
Mari et al, 1994 |
| Titanium and copper implants |
Suska et al, 2004 |
| Trypsin (+SLIGRL) |
Bretschneider et al, 1999 |
| Tuberous sclerosis complex |
Maldonado et al, 2003 |
| Uremic toxins |
Motojima et al, 2003 |
| Uric acid |
Han et al, 2006 |
| Very Low density Lipoproteins (VLDL) |
Norata et al, 2003 |
| Violacein |
Ferreira et al, 2004 |
| Vitamin D3 |
Berry et al, 2002; van Etten et al, 2007; Tse et al, 2007 |
| White wine |
Thirunavukkarasu et al, 2008 |
| Zinc |
Kim et al, 2006; Bao et al, 2007; Rudolf & Cervinka, 2008 |
