References – U

Uberti D, Carsana T, Francisconi S, Toninelli GF, Canonico PL and Memo M (2004) A novel mechanism for pergolide-induced neuroprotection: inhibition of NF-kB nuclear translocation. Biochemical Pharmacology 67 1743-1750

Uchi H, Arrighi JF, Aubry JP, Furue M and Hauser C (2002)The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway. Journal of Allergy and Clinical Immunology 110 269-276

Uchiba M, Okajima K, Kaun C, Binder BR and Wojta J (2003) Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro. Critical Care Medicine 31 1147-1153

Uchiba M, Okajima K, Kaun C, Wojta J and Binder BR (2004) Inhibition of the endothelial cell activation by antithrombin in vitro. Thrombosis and Haemostosis 92 1420-1427

Uchida J, Yasui T, Takaoka-Shichijo Y, Muraoka M, Kulwichit W, Raab-Traub N and Kikutani H (1999) Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses. Science 286 300-303

Uchida Y, Yamazaki H, Watanabe S, Hayakawa K, Meng Y, Kiramatsu N, Kasai A, Yamauchi K, Yao J and Kitamura M (2005) Enhancement of NF-kB activity by resveratrol in cytokine-exposed mesangial cells. Clinical and Experimental Immunology 142 76-83

Uchihara JN, Krensky AM, Matsuda T, Kawakami H, Okudaira T, Masuda M, Ohta T, Takasu N and Mori N (2004) Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1. International Journal of Cancer 114 747-755

Uchihara JN, Matsuda T, Okudaira T, Ishikawa C, Masuda M, Horie R, Watanabe T, Ohta T, Takasu N and Mori N (2005) Transactivation of the ICAM-1 gene by CD30 in Hodgkin’s lymphoma. International Journal of Cancer in press

Uchimura K, Nakamuta M, Enjoji M, Irie T, Sugimoto R, Muta T, Iwamoto H and Nawata H (2001) Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells. Hepatology 33 91-99

Uchinami H, Yamamoto Y, Kume M, Yonezawa K, Ishikawa Y, Taura K, Nakajima A, Hata K & Yamaoka Y (2002) Effect of heat shock preconditioning on NF-kB/I-kB pathway during I/R injury of the rat liver. American Journal of Physiology & Gastrointestinal Liver Physiology 282 G962-G971

Uchiumi F, Hatano T, Ito H, Yoshida T and Tanuma S (2003) Transcriptional suppression of the HIV promoter by natural compounds. Antiviral Research 58 89-98

Uchiyama T, Delude RL and Fink MP (2003) Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med 29 2050-2058

Uckun Fm, Dibirdik I, Qazi S, Vassilev A, Ma H, Mao C, Benyumov A and Emami KH (2006) Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK). Bioorganic Medicinal Chemistry in press

Uckun FM, Schieven GL, Tuel-Ahlgren LM, Dibirdik I, Myers DE, Ledbetter JA and Song CW (1993) Tyrosine phosphorylation is a mandatory proximal step in raditation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors. Proceedings of the National Academy of Sciences USA 90 252-256

Udagawa N, Kotake S, Kamatani N, Takahashi N and Suda T (2002) The molecular mechanism of osteoclastogenesis in rheumatoid arthritis. Arthritis Research 4 281-289

Udagawa N, Takahashi N, Yasuda H, Mizuno A, Itoh K, Ueno Y, Shinki T, Gillespie MT, Martin TJ, Higashio K and Suda T (2000) Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology 141 3478-3484

Udalova IA, Knight JC, Vidal V, Nedospasov SA and Kwiatkowski D (1998) Complex NF-kB interactions at the distal tumor necrosis factor promoter region in human monocytes. Journal of Biological Chemistry 273 21178-21186

Udalova IA and Kwiatkowski D (2001) Interaction of AP-1 with a cluster of NF-kB binding elements in the human TNF promoter region. Biochemical and Biophysical Research Communications 289 25-33

Udalova IA, Mott R, Field D and Kwiatkowski D (2002) Quantitative prediction of NF-kB DNA-protein interactions. Proceedings of the National Academy of Sciences USA 99 8167-8172

Udalova IA, Richardson A, Denys A, Smith C, Ackerman H, Foxwell B and Kwiatkoski D (2000) Functional consequences of a plymorphism affecting NF-kB p50-p50 binding to the TNF promoter region. Molecular and Cellular Biology 20 9113-9119

Udalova IA, Richardson A, Ackerman H, Wordsworth P and Kwiatkowski D (2002) Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kB binding to the TNF promoter region. Rheumatology 41 830-831

Udalova IA, Turetskaia RL, Kuprash DV and Nedospasov SA (1995) [Two steps in activating human tumor necrosis factor gene transcription in macrophages. The role of proteins from the NF-kB/Rel family in the effect of lipopolysaccharide]. Dokl Akad Nauk 342 413-417

Udalova IA, Vidal V, Scragg IG and Kwiatkowski D (2000) Direct evidence for involvement of NF-kB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein. Infection & Immunity 68 5447-5449

Uddin J, Garcia HH, Gilman RH, Gonzalez AE and Friedland JS (2005) Monocyte-astrocyte networks and the regulation of chemokine secretion in neurocysticercosis. Journal of Immunology175 3273-3281

Uddin J, Gonzalez AE, Gilman RH, Garcia HH, Verastegui M, Moore LJ, Evans CA, Read RC and Friedland JS (2006) Neurocysticercal antigens stimulate chemokine secretion from human monocytes via an NF-kB-dependent pathway. Microbes and Infection 8 1732-1740

Uebelhart D (2008) Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis and Cartilage 16 S19-S21

Ueberla K, Lu Y, Chung E and Haseltine WA (1993) The NF-kB p65 promoter. Journal of Acquired Immune Deficiency Syndromes 6 227-230

Ueda A, Ishigatsubo Y, Okubo T and Yoshimura T (1997) Transcriptional regulation of the human monocyte chemoattractant protein-1 gene: cooperation of two NF-kB sites and NF-kB/Rel subunit specificity. Journal of Biological Chemistry 272 31092-31099

Ueda A, Okuda K, Ohno S, Shirai A, Igarashi T, Matsunaga K, Fukushima J, Kawamoto S Ishigatsubo Y and Okubo T (1987) (MCP-1 gene and NF-kB). Journal of Immunology 153 2052-2063

Ueda M, Kokura S, Imamoto E, Naito Y, Handa O, Takagi T, Yoshida N and Yoshikawa T (2003) Blocking of NF-kB activation enhances the tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line. Cancer Letters 193 177-182

Ueda T, Akiyama N, Sai H, Oya N, Noda M, Hiraoka M and Kizaka-Kondoh S (2001) c-IAP2 is induced by ionizing radiation through NF-kB binding sites. FEBS Letters 491 40-44

Ueda Y, Nakagawa T, Kubota T, Ido K and Sato K (2005) Glioma cells under hypoxic conditions block the brain microvascular endothelial cell death induced by serum starvation. Journal of Neurochemistry 95 99-110

Ueda Y and Richmond A (2006) NF-kB activation in melanoma.Pigment Cell Research 19 112-124

Ueda Y, Su Y and Richmond A (2007) CCAAT displacement protein regulates nuclear factor-kappaB-mediated chemokine transcription in melanoma cells. Melanoma Research 17 91-103

Ueffing N, Schuster M, Keil E, Schulze-Osthoff K and Schmitz I (2008) Upregulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood in press

Uehara A, Hirabayashi Y and Takada H (2008) Antibodies to proteinase 3 (PR3-ANCA) prime human oral, lung, and kidney epithelial cells through protease-activated receptor-2 to secrete proinflammatory cytokines upon stimulation with agonists to various Toll-like receptors, NOD1 and NOD2. Clinical Vaccine Immunology in press

Uehara A, Iwashiro A, Sato T, Yokota S and Takada N (2007) Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kB for Toll-like receptor- and NOD-dependent activation. Molecular Immunology 44 3552-3562

Uehara A, Muramoto K, Imamura T, Nakayama K,Potempa J, Travis J, Sugawara S and Takada H (2005) Arginine-specific gingipains from porphyromonas Gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture. Journal of Immunology 175 6076-6084

Uehara A, Naito M, Imamura T, Potempa J, Travis J, Nakayama K and Takada H (2008) Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis. Journal of Medical Microbiology 57 500-507

Uehara A, Sugawara Y, Kurata S, Fujimoto Y, Fukase K, Kusumoto S, Satta Y, Sasano T, Sugawara S and Takada H (2005) Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.Cellular Microbiology 7 675-686

Uehara A, Sugawara Y, Sasano T, Takada H and Sugawara S (2004) Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2. Journal of Immunology 173 4179-4189

Uehara A and Takada H (2007) Functional TLRs and NODs in human gingival fibroblasts. Journal of Dental Research 86 249-254

Uehara A adn Takada H (2008) Synergism between TLRs and NOD1/2 in oral epithelial cells. Journal of Dental Research 87 682-686

Uehara A, Yang S, Fujimoto Y, Fukase K, Kusumoto S, Shibata K, Sugawara S and Takada H (2005) Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cellular Microbiology 7 53-61

Uehara K, Miura S, Takeuchi T, Taki T, Nakashita M, Adachi M, Inamura T, Ogawa T, Akiba Y, Suzuki H, Nagata H and Ishii H (2003) Significant role of ceramide pathway in experimental gastric ulcer formation in rats. J Pharmacol Exp Ther 305 232-239

Uehara T, Matsuno J, Kaneko M, Nishiya T, Fujimuro M, Yokosawa H and Nomura Y (1999) Transient nuclear factor kB (NF-kB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkBa molecule, in C6 glioma cells. Regulation of NF-kB linked to chemokine production. Journal of Biological Chemistry 274 15875-15882

Uehara Y (2004) PGD(2)/L-PGDS system in hypertension and renal injury. Nippon Yakurigaku Zasshi 123 23-33

Uehori J, Matsumoto M, Tsuji S, Akazawa T, Takeuchi O, Akira S, Kawata T, Azuma I, Toyoshima K and Seya T (2003) Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis Bacillus calmette-guerin peptidoglycan. Infection & Immunity 71 4238-4249

Ueki S, Yamashita K, Aoyagi T, Haga S, Suzuki T, Itoh T, Taniguchi M, Shimamura T, Furukawa H, Ozaki M, Umezawa K and Todo S (2007) Control of allograft rejection by applying a novel nuclear factor-kB inhibitor, dehydroxymethylepoxyquinomicin.Transplantation 82 1720-1727

Uematsu S and Akira S (2007) Toll-like receptors adn type I interferons. Journal of Biological Chemistry 282 15319-15323

Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O and Akira S (2005) Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-a induction. Journal of Experimental Medicine 201 915-923

Uemura H, Yasui T, Miyatani Y, Yamada M, Hiyoshi M Ansawa K and Irahara M (2008) Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor kB ligand in post-menopausal women. Journal of Endocrinology Investigation 31 163-168

Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K and Ninomiya-Tsuji J (2006) TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kB. Journal of Biological Chemistry 281 7863-7872

Uemura Y, Kobayashi M, Nakata H, Harada R, Kubota T and Taguchi H (2004) Effect of serum deprivation on constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells. International Journal of Cancer 109 826-832

Uen YH, Liu DZ, Weng MS, Ho YS and Lin SY (2007) NF-kB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells. Journal of Cellular Biochemistry in press

Ueno C, Fukatsu K, Kang W, Maeshima Y, Moriya T, Hara E, Nagayoshi H, Omata J, Saito H, Hiraide H and Mochizuki H (2005) Route and type of nutrition influence nuclear factor kB activation in peritoneal resident cells. Shock 24 382-387

Ueno H, Kajihara H, Nakamura H, Yodoi J and Nakamuro K (2007) Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kB DNA-binding promoted by selenite. Antioxidant and Redox Signaling 9 115-121

Ueno H, Pradhan S, Schlessel D, Hirasawa H and Sumpio BE (2006) Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kB, and AP-1. Cardiovascular Toxicology 6 39-50

Ueno M, Sonoda Y, Funakoshi M, Mukaida N, Nose K and Kasahara T (2000) Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW 264.7: role of kB-3 binding protein. Cytokine 12 207-219

Ueno N, Taketomi Y, Koga K, Atsumi Y, Kikuchi-Yanoshita R, Kudo I and Murakami M (2008) A negative regulator of delayed prostaglandin D(2) production in mouse mast cells. Biochimica et Biophysica Acta in press

Ueno S, Aoki D, Kubo F, Hiwatashi K, Matsushita K, Oyama T, Maruyama I and Aikou T (2005) Roxithromycin inhibits constitutive activation of nuclear factor kB by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Clincal Cancer Research 11 5645-5650

Ueno S, Campbell J and Fausto N (2006) Reactive oxygen species derived from NADPH oxidase system is not essential for liver regeneration after partial hepatectomy. Journal of SurgicalResearch in press

Ueno Y, Sakurai H, Matsuo M, Choo MK, Koizumi K and Saiki I (2005) Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib. British Journal of Cancer 92 1690-1695

Ueshima Y, Bird ML, Vardiman JW and Rowley JD (1985) A 14;19 translocation in B-cell chronic lymphocytic leukemia: a new recurring chromosome aberration. International Journal of Cancer 36 287-290

Uesugi M, Nyanguile O, Lu H, Levine AJ and Verdine GL (1997) Induced a helix in the VP16 activation domain upon binding to a human TAF. Science 277 1310-1313

Uesugi T, Froh M, Arteel GE, Bradford BU, Gabele E, Wheeler MD and Thurman RG (2001) Delivery of IkB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. Hepatology 34 1149-1157

Ueta M, Hamuro J, Kiyono H and Kinoshita S (2005) Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochemical and Biophysical Research Communications 331 285-294

Ueta M, Hamuro J, Yamamoto M, Kaseda K, Akira S and Kinoshita S (2005) Spontaneous ocular surface inflammation and goblet cell disappearance in IkBz gene-disrupted mice. Invest Ophthalmol Vis Sci 46 579-588

Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S and Kiyono H (2004) Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. Journal of Immunology 173 3337-3347

Uetama T, Ohno-Matsui K, Nakahama K, Morita I and Mochizuki M (2003) Phenotypic change regulates monocyte chemoattractant protein-1 (MCP-1) gene expression in human retinal pigment epithelial cells. Journal of Cell Physiology 197 77-85

Uetani K, Arroliga ME and Erzurum SC (2001) Double-stranded rna dependence of nitric oxide synthase 2 expression in human bronchial epithelial cell lines BET-1A and BEAS-2B. Am J Respir Cell Mol Biol 24 720-726

Uetsuka H, Haisa M, Kimura M, Gunduz M, Kaneda Y, Ohkawa T, Takaoka M, Murata T, Nobuhisa T, Yamatsuji T, Matsuoka J, Tanaka N and Naomoto Y (2003) Inhibition of inducible NF-kB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line. Experimental Cell Research 289 27-35

Uffort DG, Grimm EA and Ellerhorst JA (2008) NF-kB mediates mitogen-activated protein kinase pathway-dependent iNOS expression in human melanoma. Journal of Investigative Dermatology in press

Uhl EW, Giguere S, Jack TJ and Hodge T (2002) Increased pulmonary activation of nuclear factor-kB (NF-kB) in foals inoculated with Rhodococcus equi is associated with increased expression of inflammatory cytokines. Veterinary Pathology 39 132-136

Uhlig U, Fehrenbach H, Lachmann RA, Goldmann T, Lachmann B, Vollmer E and Uhlig S (2004) Phosphoinositide 3-OH kinase inhibition prevents ventilation-induced lung cell activation. Am J Respir Crit Care Med 169 201-208

Uhlig U, Haitsma JJ, Goldmann T, Poelma DL, Lachmann B and Uhlig S (2002) Ventilation-induced activation of the mitogen-activated protein kinase pathway. Eur Respir J 20 946-956

Uhlik M, Good LF, Xiao G, Harhaj EW, Zandi E, Karin M and Sun S-C (1998) NF-kB-inducing kinase and IkB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kB activation. Journal of Biological Chemistry 273 21132-21136

Uhrig A, Banafsche R, Kremer M, Hegenbarth S, Hamann A, Neurath M, Gerken G, Limmer A and Knolle PA (2005) Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver. Journal of Leukocyte Biology 77 626-633

Ukai T, Yumoto H, Gibson 3rd FC and Genco CA (2007) Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2 dependent tumor necrosis factor-a production. Infection and Immunity 76 812-819

Ukil A, Biswas A, Das T and Das PK (2005) 18beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral Leishmaniasis associated with the activation of NF-kB. Journal of Immunology 175 1161-1169

Ukil A, Maity S and Das PK (2006) Protection from experimental colitis by theaflavin-3,3′-digallate correlates with inhibition of IKK and NF-kB activation. British Journal of Pharmacology in press

Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR and Das PK (2003) Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. British Journal of Pharmacology 139 209-218

Ukon K, Tanimoto K, Shimokuni T, Noguchi T, Hiyama K, Tsujimoto H, Fukushima M, Toge T and Nishiyama M (2005) Activator protein accelerates dihydropyrimidine dehydrogenase gene transcription in cancer cells. Cancer Research 65 1055-1062

Ulanova M, Marcet-Palacios M, Munoz S, Asfaha S, Kim MK, Schreiber AD and Befus AD (2006) Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells.
Biochemical and Biophysical Research Communications 351 431-437

Ulbrich C, Westphal K, Baatout S, Wehland M, Bauer J, Flick B, Infanger M, Kreutz R, Vadrucci S, Egli M, Cogoli A, Derradji H, Pietsch J, Paul M and Grimm D (2008) Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity. Journal of Cellular Biochemistry in press

Ulevitch RJ (2001) New therapeutic targets revealed through investigations of innate immunity. Critical Care Medicine 29 S8-S12

Ulfhammer E, Larsson P, Karlsson L, Hrafnkelsdottir T, Bokarewa M Tarkowski A and Jern S (2006) TNF-a mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kB- and p38 MAPK-dependent. Journal of Thrombosis and Haemostosis 4 1781-1789

Ulivi V, Tutolo G, Mallein-Gerin F, Daga A, Cancedda R and Cancedda FD (2005) A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes. Journal of Cell Physiology 206 728-737

Ulleras E, Karlberg M, Moller Westerberg C, Alfredsson J, Gerondakis S, Strasser A and Nilsson G (2008) NFAT but not NF-kB is critical for transcriptional induction of the pro-survival gene A1 following IgE receptor activation in mast cells. Blood in press

Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP and Tracey KJ (2002) Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proceedings of the National Academy of Sciences USA 99 12351-12356

Ulloa L and Wang P (2007) The neuronal strategy for inflammation. Novartis Foundation Symposium 280 223-233

Ullrich O, Diestel A, Eyupoglu IY and Nitsch R (2001) Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1. Nature Cell Biology 3 1035-1042

Ulrich E, Boehmelt G, Bird A and Beug H (1992) Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation. Genes & Development 6 876-887

Um HR, Lim WC, Chae SY, Park JH and Cho H (20060 Raf-1 and protein kinase B regulate cell survival through the activation of NF-kB in hepatitis B virus X-expressing cells. Virus Research in press

Um JH, Kang CD, Lee BG, Kim SW, Chung BS and Kim SH (2001) Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance. Oncogene 20 6048-6056

Um JH, Kwon JK, Kang CD, Kim MJ, Ju DS, Bae JH, Kim DW, Chung BS and Kim SH (2004) Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade. Journal of Pharmacology and Experimental Therapeutics 311 1062-1070

Um M and Lodish HF (2006) Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. Journal of Biological Chemistry 281 5648-5656

Umannova L, Zatloukalova J, Machala M, Krcmar P, Majkova Z, Hennig B, Kozubik A and Vondracek J (20070 Tumor necrosis factor-a modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver ‘stem-like’ cells. Toxicological Sciences in press

Umansky V, Hehner SP, Dumont A, Hofmann TG, Schirrmacher V, Droge W and Schmitz ML (1998) Co-stimulatory effect of nitric oxide on endothelial NF-kB implies a physiological self-amplifying mechanism. European Journal of Immunology 28 2276-2282

Umar S, Sarkar S, Cowey S and Singh P (2008) Activation of NF-kB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo. Oncogene in press

Umezawa K (2006) Inhibition of tumor growth by NF-kB inhibitors. Cancer Science 97 990-995

Umezawa K, Ariga A and Matsumoto N (2000) Naturally occurring and synthetic inhibitors of NF-kB functions. Anti-Cancer Drug Design 15 239-244

Umezawa K and Chaicharoenpong C (2002) Molecular design and biological activities of NF-kB inhibitors. Molecules and Cells 14 163-167

Umland O, Heine H, Miehe M, Marienfeld K, Staubach KH and Ulmer AJ (2004) Induction of various immune modulatory molecules in CD34+ hematopoietic cells. Journal of Leukocyte Biology 75 671-679

Umland SP, Schleimer RP and Johnston SL (2002) Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma. Pulm Pharmacol Ther 15 35-50

Underhill DM (2003) Macrophage recognition of zymosan particles. Journal of Endotoxin Research 9 176-180

Underhill DM, Ozinsky A, Smith KD and Aderem A (1999) Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proceedings of the National Academy of Sciences USA 96 14459-14463

Underhill GH, George D, Bremer EG and Kansas GS (2003) Gene expression profiling reveals a highly specialized genetic program of plasma cells. Blood 101 4013-4021

Ungvari Z, Wolin MS and Csiszar A (2006) Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling? Antioxidant andRedox Signaling 8 1121-1129

Ungvari ZI, Orosz Z, Labinskyy N, Rivera Z, Xiangmin Z, Smith KE and Csiszar A (2007) Increased mitochondrial H2O2 production promotes endothelial NF-kB activation in aged rat arteries.American Journal of Physiology: Heart and Circulatory Physiology in press

Unlap T, Jope RS (1995) Inhibition of NFkB DNA binding activity by glucocorticoids in rat brain. Neuroscience Letters 198 41-44

Unlap T and Jope RS (1995) Glucocorticoids attenuate AP-1 and NFkB DNA binding activities in rat brain: implication of glucocorticoids in neuronal degeneration. Abstract of the American Society for Cell Biology, Molecular Biology of the Cell 241a 1397

Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, Heins G, Ehrhardt C and Wolff T (2005) Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kB activator (TANK)-binding kinase-1. Proceedings of the National Academy of Sciences USA 102 13640-13645

Upadhyay AK, Singh S, Chhipa RR, Vijayakumar MV, Ajay AK and Bhat MK (2006) Methyl-beta-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: Involvement of Akt, NF-kB and Bcl-2. Toxicology and Applied Pharmacology 216 177-185

Urashima M, Sakuma M, Teramoto S, Fuyama Y, Eto Y, Kondo K and Tanaka T (2005) Gene expression profiles of peripheral and cord blood mononuclear cells altered by thymic stromal lymphopoietin. Pediatric Research 57 563-569

Urban MB and Baeuerle PA (1991) The role of the p50 and p65 subunits of NF-kB in the recognition of cognate sequences. The New Biologist 3 279-288

Urban MB, Schreck R and Baeuerle PA (1991) NF-kB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO Journal 10 1817-1825

Urban TA, Griffith A, Torok AM, Smolkin ME, Burns JL and Goldberg JB (2004) Contribution of Burkholderia cenocepacia flagella to infectivity and inflammation. Infection and Immunity 72 5126-5134

Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M and Rusnati M (2005) {alpha}v{beta}3-integrin-dependent activation of focal adhesion kinase mediates NF-{kappa}B activation and motogenic activity by HIV-1 Tat in endothelial cells. Journal of Cell Science 118 3949-3958

Urbinati C, Mitola S, Tanghetti E, Kuman C, Waltenberger J, Ribatti D, Presta Mand Rusnati M (2005) Integrin alphaVbeta3 as a target for blocking HIV-1 Tat-induced endothelial cell activation in vitro and angiogenesis in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology 25 2315-2320

Urnowey S, Ansai T, Bitko V, Nakayama K, Takehara T and Barik S (2006) Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: potential role of bacterial proteases in host signalling. BMC Microbiology 6 26

Ursini-Siegel J, Zhang W, Altmeyer A, Hatada EN, Do RK, Yagita H and Chen-Kiang S (2002) TRAIL/Apo-2 ligand induces primary plasma cell apoptosis. Journal of Immunology 169 5505-5513

Uskokovic A, Dinic S, Mihailovic M, Grigorov I,Ivanovic-Matic S, Bogojevic D, Grdovic N, Arambasic J, Vidakovic M, Martinovic V, Petrovic V, Petrovic M and Poznanovic G (2007) STAT3/NFkB interplay in the regulation of alpha(2)-macroglobulin gene expression during rat liver development and the acute phase response. IUBMB Life 59 170-178

Usluoglu N, Pavlovic J, Moelling K and Radziwill G (2007) RIP2 mediates LPS-induced p38 and IkBa signaling including IL-12 p40 expression in human monocyte-derived dendritic cells.
European Journal of Immunology in press

Ustyugova IV, Frost LL, Vandyke K, Brundage KM, Schafer R and Barnett JB (2007) 3,4-dichloropropionaniline suppresses normal macrophage function. Toxicological Sciences 97 364-374

Usui H, Shikata K, Matsuda M, Okada S, Ogawa D, Yamashita T, Hida K, Satoh M, Wada J and Makino H (2003) HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats. Nephrology, Dialysis and Transplantation 18 265-272

Usui M, Egashira K, Tomita H, Koyanagi M, Katoh M, Shimokawa H, Takeya M, Yoshimura T, Matsushima K and Takeshita A (2000) Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats. Circulation 101 305-310

Utaisincharoen P, Arjcharoen S, Lengwehasatit I, Limposuwan K and Sirisinha S (2005) Burkholderia pseudomallei invasion and activation of epithelial cells requires activation of p38 mitogen-activated protein kinase. Microbial Pathogenesis 38 107-112

Uto T, Fujii M and Hou DX (2005) Inhibition of lipopolysaccharide-induced cyclooxygenase-2 transcription by 6-(methylsulfinyl) hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages. Biochemical Pharmacology 70 1772-1784

Uto T, Fujii M and Hou DX (2007) Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-gamma and 12-O-tetradecanoylphorbol-13-acetate. Oncology Reports 17 233-238

Uto T, Wang X, Sato K, Haraguchi M, Akagi T, AKashi M and Baba M (2007) Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity. Journal of Immunology 178 2979-2986

Utsugi M, Dobashi K, Ishizuka T, Kawata T, Hisada T, Shimizu Y, Ono A and Mori M (2006) Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kB p65 trans activation plays a novel role. Journal of Immunology 177 4550-4557

Uvell H and Engstrom Y (2007) A multilayered defense against infection: combinatorial control of insect immune genes.
Trends in Genetics in press

Uwagawa T, Li Z, Chang Z, Xia Q, Peng B, Sclabas GM, Ishiyama S, Hung MC, Evans DB, Abbruzzese JL and Chiao PJ (2007) Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death. Cancer 109 2142-2153

Uv AE, Roth P, Xylourgidis N, Wickberg A, Cantera R and Samakovlis C (2000) members only encodes a drosophila nucleoporin required for rel protein import and immune response activation. Genes & Development 14 1945-1957

Uvell H and Engstrom Y (2003) Functional characterization of a novel promoter element required for an innate immune response in Drosophila. Molecular and Cellular Biology 23 8272-8281

Uwe S (2007) Anti-inflammatory interventions of NF-kB signaling: potential applications and risks. Biochemical Pharmacology in press

Uy GL, Trivedi R, Peles S, Fisher NM, Zhang QJ, Tomasson MH, Dipersio JF and Vij R (2007) Bortezomib inhibits osteoclast activity in patients with multiple myeloma. Clinical Lymphoma and Melanoma 7 587-589

Uzel G (2005) The range of defects associated with nuclear factor kB essential modulator. Current Opinion in Allergy and Clinical Immunology 5 513-518

Uzel G and Holland SM (2002) White blood cell defects: molecular discoveries and clinical management. Current Allergy and Asthma Reports 2 385-391

Uzun O and Demiryurek AT (2003) Nuclear factor-kB inhibitors abolish hypoxic vasoconstriction in sheep-isolated pulmonary arteries. European Journal of Pharmacology 458 171-174

Uzzo RG, Crispen PL, Golovine K, Makhov P, Horwitz EM and Kolenko VM (2006) Diverse effects of zinc on NF-kB and AP-1 transcription factors: implications for prostate cancer progression. Carcinogenesis 27 1980-1990

Uzzo RG, Leavis P, Hatch W, Gabai VL, Dulin N, Zvartau N and Kolenko VM (2002) Zinc inhibits nuclear factor-kB activation and sensitizes prostate cancer cells to cytotoxic agents. Clincal Cancer Research 8 3579-3583

Uzzo RG, Rayman P, Kolenko V, Clark PE, Cathcart MK, Bloom T, Novick AC, Bukowski RM, Hamilton T and Finke JH (1999) Renal cell carcinoma-derived gangliosides suppress nuclear factor-kB activation in T cells. Journal of Clinical Investigation 104 769-776