Lucia Pastorino

Lucia Pastorino is a Master Lecturer in Neuroscience at Boston University, College of Arts and Sciences. She earned a BS in Medicinal Chemistry and a Ph.D. in Neuropharmacology from the University of Milan, Italy. Prior to joining BU, she conducted research in the field of the biology of Alzheimer’s disease at research institutions in the United States and in Europe. She was also an adjunct faculty at Brandeis University, and an Instructor at Harvard Medical School and Harvard University/Harvard Extension School. She currently designs and teaches research-based laboratories and lecture courses in her field of expertise, including NE/BI 561 Proteostasis in the Biology of Neurodegenerative Diseases, NE/BI 525 Biology of Neurodegenerative Diseases, NE/BI 535 Translational Research in Alzheimer’s Disease, NE102 Introduction to Cell and Molecular Biology, and has also co-taught CC212 Reality, Science and the Modern World.

Selected Publications:

(for a complete list of publications visit Google Scholar)

Lucia Pastorino*, Suk Ling Ma, Martin Balastik, Pengyu Huang, Darshan Pandya, Linda Nicholson and Kun Ping Lu. Alzheimer’s disease-related loss of Pin1 function influences the intracellular localization and the processing of AbPP. Journal of Alzheimer’s Disease, 2012; 30(2):277-97.

L.Pastorino*, A. Kondo, X.Z. Zhou and K.P. Lu Pin1 protects against Alzheimer’s disease: one goal, multiple mechanisms. Book Chapter in “Alzheimer’s Disease” edited by Inga Zarr. Intech Publishing Company, 2012.

Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides. Neuron, 2012; 75. 5: 824-37.

L. Pastorino, A.Sun, P.J. Lu, X. Z. Zhou, M. Balastik, G. Finn, G. Wulf, J. Lim, S.H. Li, X. Li, W. Xia, L. K. Nicholson and K. P. Lu. Pin1-catalyzed prolyl isomerization regulates amyloid precursor protein processing and Abeta production. Nature 2006;440(7083):528-34.

L. Pastorino, A.F. Ikin, S. Lambrianou, N. Vacaresse, J.P. Revelli, K. Platt, P. Paganetti, P. M. Mathews, S. Harroch, and J.D. Buxbaum. BACE (b-secretase) modulates the processing of APLP2 in vivo. Mol. Cell. Neurosci. 2004;25:624-649.

Pastorino L, Ikin AF, Nairn AC, Pursnani A, Buxbaum J.D. The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol. Cell. Neurosci. 2002;19:175-85.

Knight M, Pastorino L, Lee S, Spilios K, Co E, McIntyre M, and Lipton PA. Re-envisioining the Introductory Science Course as a Cognitive Apprenticeship. Journal of College Science Teaching, 2015.