Publications

See the lists below for a selection of peer-reviewed publications by year with two or more Center faculty as authors.

2026

Grifno GN, Kahvecioglu, HA, LeBourdais, Travnik V, Banerji R, Wangsrikun W, Shi L, Bozal SB, Suh H, Raslan AA, Batgidis A, Kang B, Deng F, Dalton C, Tsao A, Castle L, Ligresti G, Mizgerd J, Longest W, Hindle M, Saltzman WM, Butler J, Suki B, Nia HT Real-time single-particle imaging of functional lungs reveals mosaic-like patterns of aerosol deposition in alveoli. Nat. Biomed. Eng (2026). https://doi.org/10.1038/s41551-026-01724-5

Dogru S, Simone N, Haciguzeller HZ, Alba GM, Layne MD, Albro MB. Latent TGF- content of articular cartilage with development and age. Connect Tissue Res, 2026 Jan; 67(1)2-12. https://doi.org/10.1080/03008207.2025.2543383

Saha A, Jones JM, Plummer A, Larkin JW. Formation of a swelling gel underlies a morphological transition in Bacillus subtilis biofilms. bioRxiv, 2026.02.20.707077. https://doi.org/10.64898/2026.02.20.707077

Liu FA, Dawes BA, Torg WJ, Manichelli E, Peter JC, Kamenetska M. “Single Molecule Force Measurements Reveal Energy Stabilization of Theophylline Aptamer RNA Switch Required for Gene Control.” ACS Phys. Chem Au 2026, 6, 2, 301–307. https://doi.org/10.1021/acsphyschemau.5c00109

Hall JK, Deng Y, Kontodimas K, Nia H, Varelas X, Lutchen KR, Bates J, Suki B. A large-scale balloon model of confluent cells validates stress inference from geometry. NPJ Biol Phys Mech. 2026;3(1):1. https://doi.org/10.1038/s44341-025-00031-5

Halvorsen, SC, Mlawer, SJ, Then, RM, Stein T, Connizzo, BK, and Zhang, Y, 2026. Age-Related Biomechanical and Structural Remodeling of Human Middle Cerebral Arteries. Under revision.

2025

2024

Kobeissi H, Gao X, DePalma SJ, Ewoldt JK, Wang MC, Das SL, Jilberto J, Nordsletten D, Baker BM, Chen CS, Lejeune E. MicroBundlePillarTrack: A Python package for automated segmentation, tracking, and analysis of pillar deflection in cardiac micro-bundles. MicroPubl Biol. 2024 Jul 23;2024:10.17912/micropub. biology.001231. doi: 10.17912/micropub.biology.001231. doi: 10.17912/micropub.biology.001231

Aggouras AN, Stowe EJ, Mlawer SJ, Connizzo BK. Aged Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling. J Biomech Eng. 2024 Jul 1;146(7):071009. PMID: 38584416; PMCID: PMC11080950. https://doi.org/10.1115/1.4065270

Wang T, Kim SY, Peng Y, Zheng J, Layne MD, Murphy-Ullrich JE, Albro MB. Autoinduction-Based Quantification of In Situ TGF-b Activity in Native and Engineered Cartilage. Tissue Eng Part C Methods. 2024 Nov; 30(11):522-532. PMID: 39311474

Li L, Griebel ME, Uroz M, Bubli SY, Gagnon KA, Trappmann B, Baker BM, Eyckmans J, Chen CS, A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses. Adv. Funct. Mater. 2024, 34, 2309567. https://doi.org/10.1002/adfm.202309567

Stowe EJ, Keller MR, Connizzo BK. Cellular senescence impairs tendon extracellular matrix remodeling in response to mechanical unloading. Aging Cell. 2024 Nov;23(11):e14278. doi: 10.1111/acel.14278. Epub 2024 Jul 22. PMID: 39039843; PMCID: PMC11561669. https://doi.org/10.1111/acel.14278Digital Object Identifier (DOI)

Zheng Siyi, Banerji R, LeBourdais R, Zhang Sue, DuBois E, O’Shea T, Nia HT. Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke. PNAS Nexus, Volume 3, Issue 4, April 2024, pgae141, https://doi.org/10.1093/pnasnexus/pgae141

Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC and Mizgerd JP (2024). B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front. Immunol. 15:1382638. https://doi.org/10.3389/fimmu.2024.1382638

LeBourdais R, Grifno GN, Banerji R, Regan K, Suki B and Nia HT (2024) Mapping the strain-stiffening behavior of the lung and lung cancer at microscale resolution using the crystal ribcage. Front. Netw. Physiol. 4:1396593. doi: 10.3389/fnetp.2024.1396593 https://doi.org/10.3389/fnetp.2024.1396593

2023

2022

Li HS, Wong NM, Tague E, Ngo JT, Khalil AS, Wong WW. High-performance multiplex drug-gated CAR circuits. Cancer Cell. 2022, 40(11):1294-1305.e4. https://doi.org/10.1016/j.ccell.2022.08.008

Alhousami T, Diny M, Ali F, Shin J, Kumar G, Kumar V, Campbell J, Noonan V, Hanna G, Denis G, Monti S, Kukuuzinska, Varelas X, and Bais M. Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition. Molecular Cancer Research, 2022, 20(5): 712-721. https://doi.org/10.1158/1541-7786.MCR-21-0310

Das SL, Sutherland BP, Lejeune E, Eyckmans J, & Chen CS (2022). Mechanical response of cardiac microtissues to acute localized injury. American Journal of Physiology-Heart and Circulatory Physiology, 323(4), H738–H748. https://doi.org/10.1152/ajpheart.00305.2022

Michas C, Karakan MÇ, Nautiyal P, Seidman JG, Seidman CE, Agarwal A, Ekinci K, Eyckmans J, White AE, & Chen CS. (2022). Engineering a living cardiac pump on a chip using high-precision fabrication. Science Advances, 8(16). https://www.science.org/doi/10.1126/sciadv.abm3791

Tefft JB, Bays JL, Lammers A, Kim S, Eyckmans J, & Chen CS. (2022). Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature. American Journal of Physiology-Cell Physiology, 322(2), C185–C196. https://doi.org/10.1152/ajpcell.00320.2021

Abood A, Mesner L, Rosenow W, Al-Barghouthi BM, Horowitz N, Morgan EF, Gerstenfeld LC, & Farber CR (2022). Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci. Journal of Bone and Mineral Research, 37(8), 1500–1510. https://doi.org/10.1002/jbmr.4622

Al-Barghouthi BM, Rosenow WT, Du KP, Heo J, Maynard R, Mesner L, Calabrese G, Nakasone A, Senwar B, Gerstenfeld L, Larner J, Ferguson V, Ackert-Bicknell C, Morgan, EF, Brautigan D, & Farber CR (2022). Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations. ELife, 11, e77285. https://doi.org/10.1101/2021.10.12.464046

Auger JD, Naik AJ, Murakami AM, Gerstenfeld LC, & Morgan EF (2022). Spatial assessment of femoral neck bone density and microstructure in hip osteoarthritis. Bone Reports, 16, 101155. PMCID: PMC8693349

Bragdon BC, Bennie A, Molinelli A, Liu Y, & Gerstenfeld LC (2022). Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues. Journal of Cellular Physiology, 237(5), 2550–2560. 10.1002/jcp.30728

Nakasone A, Guang, Y, Wise A, Kim L, Babbin J, Rathod S, Mitchell AJ, Gerstenfeld LC, & Morgan EF (2022). Structural features of subchondral bone cysts and adjacent tissues in hip osteoarthritis. Osteoarthritis and Cartilage, 30(8), 1130–1139. https://doi.org/10.1016/j.joca.2022.03.013

Kroupa KR, Wu MI, Zhang J, Jensen M, Wong W, Engiles JB, Schaer TP, Grinstaff MW, Snyder BD, Bergholt MS, & Albro MB (2022). Raman needle arthroscopy for in vivo molecular assessment of cartilage. Journal of Orthopaedic Research, 40(6), 1338–1348. https://doi.org/10.1002/jor.25155

Bacon KL, Felson DT, Jafarzadeh SR, Kolachalama VB, Hausdorff JM, Gazit E, Segal NA, Lewis CE, Nevitt MC, & Kumar D (2022). Relation of gait measures with mild unilateral knee pain during walking using machine learning. Scientific Reports, 12(1), Article 1. https://doi.org/10.1038/s41598-022-21142-2

Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, & Farmer SR (2022). Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Science Alliance, 5(5), e202101286. https://doi.org/10.26508/lsa.202101286

Li, J-S, Tsai T-Y, Clancy MM, Lewis CL, Felson DT, & Li G (2022). Cartilage contact characteristics of the knee during gait in individuals with obesity. Journal of Orthopaedic Research, 40(11), 2480–2487. https://doi.org/10.1002/jor.25288

Yuan Z, Herrmann J, Murthy S, Peters K, Gerard SE, Nia HT, Lutchen KR, & Suki B (2022). A Personalized Spring Network Representation of Emphysematous Lungs From CT Images. Frontiers in Network Physiology, 2, 828157. https://doi.org/10.3389/fnetp.2022.828157

Huyan C, Golden A, Zhu X, Mehta P, & Sgro A (2022). Identifying key network features coordinating robust collective signaling oscillations. ADS, W04.003. https://ui.adsabs.harvard.edu/abs/2022APS..MARW04003H

Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, & Gerstenfeld LC (2022). Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus, 6(2), e10579. https://doi.org/10.1002/jbm4.10579

Zhang S, Passaro R, Regan K, Hadzipasic M, Grifno G, Zheng S, O’Connor L, Chu V, Kim SY, Yang J, Banerji R, Karrobi K, Roblyer D, Grinstaff M, & Nia H (2022). In vivo multiscale measurements of solid stresses in tumors reveal scale-dependent stress transmission [Preprint]. Nature. In Review.
https://doi.org/10.21203/rs.3.rs-1697924/v1

Karagianni A, Matsuura S, Gerstenfeld LC, & Ravid K (2022). Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice with Primary Myelofibrosis. Frontiers in Oncology, 12, 929498. https://doi.org/10.3389/fonc.2022.929498

Milkovich N, Gkousioudi A, Seta F, Suki B, & Zhang Y (2022). Harmonic Distortion of Blood Pressure Waveform as a Measure of Arterial Stiffness. Frontiers in Bioengineering and Biotechnology, 10.
https://www.frontiersin.org/articles/10.3389/fbioe.2022.842754

Bunde KA, Stamenović D, & Smith M L (2022). Pattern Generation for Micropattern Traction Microscopy. Journal of Visualized Experiments, 180, 63628. https://doi.org/10.3791/63628

Figueiredo J, Ferreira RM, Xu H, Gonçalves M, Barros-Carvalho A, Cravo J, Maia AF, Carneiro P, Figueiredo C, Smith ML, Stamenović D, Morais-de-Sá E, & Seruca R (2022). Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric Cancer, 25(1), 124–137. https://doi.org/10.1007/s10120-021-01239-9

Xu H, Bunde KA, Figueiredo J, Seruca R, Smith ML, & Stamenović D (2022). Differential Impacts on Tensional Homeostasis of Gastric Cancer Cells Due to Distinct Domain Variants of E-Cadherin. Cancers, 14(11), Article 11. https://doi.org/10.3390/cancers14112690

Bartolák-Suki E, Mondoñedo JR, & Suki B (2022). Mechano-inflammatory sensitivity of ACE2: Implications for the regional distribution of SARS-CoV-2 injury in the lung. Respiratory Physiology & Neurobiology, 296, 103804.
https://doi.org/10.1016/j.resp.2021.103804

Shi L, Herrmann J, Bou Jawde S, Bates JHT, Nia HT, & Suki B (2022). Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure–volume curves. Scientific Reports, 12(1), 12280. https://doi.org/10.1038/s41598-022-16650-0

Gkousioudi A, Yu X, Ferruzzi J, Qian J, Wainford RD, Seta F, & Zhang Y (2022). Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging. Frontiers in Bioengineering and Biotechnology, 10, 862996. https://doi.org/10.3389/fbioe.2022.862996

2021

Kroupa K, Wu MI, Zhang J, Jensen M, Wong W, Engiles J, Schaer T, Grinstaff M, Snyder B, Bergholt M, and Albro M. Raman needle arthroscopy for in vivo molecular assessment of cartilage. Journal of Orthopaedic Research, 2021, 40(6):1338-1348. https://doi.org/10.1002/jor.25155

Das S, Bose P, Lejeune E, Reich DH, Chen C, & Eyckmans J (2021). Extracellular matrix alignment directs provisional matrix assembly and three-dimensional fibrous tissue closure. Tissue Engineering Part A, 27(23–24), 1447–1457. https://doi.org/10.1089/ten.tea.2020.0332

Kim S, Uroz M, Bays JL, & Chen CS (2021). Harnessing mechanobiology for tissue engineering. Developmental Cell, 56(2), 180–191. https://doi.org/10.1016/j.devcel.2020.12.017

Song J, Michas C, Chen CS, White,AE, & Grinstaff MW (2021). Controlled cell alignment using two-photon direct laser writing-patterned hydrogels in 2D and 3D. Macromolecular Bioscience, 21(5), 2100051. https://doi.org/10.1002/mabi.202100051

Tefft JB, Chen CS & Eyckmans J (2021). Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure. APL Bioengineering, 5(1), 016102. https://doi.org/10.1063/5.0028651

Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O’Neill EB, Eyckmans J, Chen CS, Fu J, & Schlaepfer DD (2021). Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nature Communications, 12(1), 2359. https://doi.org/10.1038/s41467-021-22602-5

Zeng J, Weng J, Zhang Y, Xia F, Cui Q, & Xu X (2021). Conformational Features of Ras: Key Hydrogen-Bonding Interactions of Gln61 in the Intermediate State during GTP Hydrolysis. The Journal of Physical Chemistry B, 125(31), 8805–8813. https://doi.org/10.1021/acs.jpcb.1c04679

Zhang Y, Dahal U. Feng ZV, Rosenzweig Z, Cui Q, & Hamers RJ (2021). Influence of surface ligand molecular structure on phospholipid membrane disruption by cationic nanoparticles. Langmuir, 37(24), 7600–7610. https://doi.org/10.1021/acs.langmuir.1c01146

Das, SL, Bose, P, Lejeune, E, Reich, DH, Chen, C, & Eyckmans, J (2021). Extracellular matrix alignment directs provisional matrix assembly and three-dimensional fibrous tissue closure. Tissue Engineering Part A, 27(23–24), 1447–1457. https://doi.org/10.1089/ten.tea.2020.0332

Cheng R, Lai R, Peng C, Lopez J, Li Z, Naowarojna N, Li K, Wong C, Lee N, Whelan SA, Qiao L, Grinstaff MW, Wang J, Cui Q, & Liu P (2021). Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C–S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis. ACS Catalysis, 11(6), 3319–3334. https://doi.org/10.1021/acscatal.0c04886

Song J, Korunes-Miller J, Banerji R, Wu Y, Fazeli S, Zheng H, Orr B, Morgan E, Andry C, Henderson J, Miller NS, White A, & Grinstaff MW (2021). On-Site, On-Demand 3D-Printed Nasopharyngeal Swabs to Improve the Access of Coronavirus Disease-19 Testing. Global Challenges, 5(11), 2100039. https://doi.org/10.1002/gch2.202100039

Song J, Michas C, Chen CS, White AE, & Grinstaff MW (2021). Controlled Cell Alignment Using Two-Photon Direct Laser Writing-Patterned Hydrogels in 2D and 3D. Macromolecular Bioscience, 21(5), 2100051. https://doi.org/10.1002/mabi.202100051

Sonnenberg AH, Taylor E, Mondoñedo JR, Jawde SB, Amin SD, Song J, Grinstaff MW & Suki B (2021). Breath Hold Facilitates Targeted Deposition of Aerosolized Droplets in a 3D Printed Bifurcating Airway Tree. Annals of Biomedical Engineering, 49(2), 812–821. https://doi.org/10.1007/s10439-020-02623-9

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul, I, Phanse, S, Youssef, A, Alysandratos, Varelas X, Layne MD… Emili, A (2021). Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell, 81(1), 212. https://doi.org/10.1016/j.molcel.2020.12.028

Corrigan P, Felson DT, Lewis CL, Gross K, Nevitt, M., Lewis, CE, Torner, JC, & Stefanik JJ (2021). Influence of peak impact force magnitude and symmetry on the progression from unilateral to bilateral knee pain: The most study. Osteoarthritis and Cartilage, 29, S184. https://doi.org/10.1016/j.joca.2021.02.251

Corrigan P, Felson DT, Lewis CL, Neogi T., LaValley MP, Gross KD, Nevitt MC, Lewis, CE, Torner JC, & Stefanik JJ (n.d.). Relation of Temporal Asymmetry During Walking to Two-Year Knee Pain Outcomes in Those with Mild-to-Moderate Unilateral Knee Pain: An Exploratory Analysis From the Multicenter Osteoarthritis Study. Arthritis Care & Research, n/a(n/a). https://doi.org/10.1002/acr.25050

Costello KE, Felson DT, Neogi T, Segal NA, Lewis CE, Gross KD, Nevitt MC, Lewis CL, & Kumar D (2021). Ground reaction force patterns in knees with and without radiographic osteoarthritis and pain: Descriptive analyses of a large cohort (the Multicenter Osteoarthritis Study). Osteoarthritis and Cartilage, 29(8), 1138-1146. https://doi.org/10.1016/j.joca.2021.03.009

Stefanik JJ, Felson DT, Rabasa G, Guermazi A, Roemer F, Lynch J, Lewis CE, Torner J, & Lewis CL (2021). Relation of hip abductor strength to worsening cartilage damage in the knee: The multicenter osteoarthritis study. Osteoarthritis and Cartilage, 29, S399. https://doi.org/10.1016/j.joca.2021.02.517

Jawde SB, Karrobi K, Roblyer D, Vicario F, Herrmann J, Casey D, Lutchen KR, Stamenović D, Bates JH, & Suki B (2021). Inflation instability in the lung: An analytical model of a thick-walled alveolus with wavy fibres under large deformations. Journal of the Royal Society Interface, 18(183), 20210594. https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2021.0594?download=true

Huyan C, Golden A, Zhu X, Mehta P, & Sgro AE (2021). Robust coordination of collective oscillatory signaling requires single-cell excitability and fold-change detection (p. 2021.09.02.457527). bioRxiv. https://doi.org/10.1101/2021.09.02.457527

Papadakis L, Kanakousaki D, Bakopoulou A, Tsouknidas A, & Michalakis K (2021). A finite element model of an osteoblast to quantify the transduction of exogenous forces to cellular components. Medical Engineering & Physics, 94, 61–69. https://doi.org/10.1016/j.medengphy.2021.06.010

Morgan EF & Gerstenfeld LC (2021). Chapter 2 – The bone organ system: Form and function. In D. W. Dempster, J. A. Cauley, M. L. Bouxsein, & F. Cosman (Eds.), Marcus and Feldman’s Osteoporosis (Fifth Edition) (pp. 15–35). Academic Press. https://doi.org/10.1016/B978-0-12-813073-5.00002-2

Song J, Korunes-Miller J, Banerji R, Wu Y, Fazeli S, Zheng H, Orr B, Morgan EF, Andry C., Henderson J, Miller NS, White A, & Grinstaff MW (2021). On-Site, On-Demand 3D-Printed Nasopharyngeal Swabs to Improve the Access of Coronavirus Disease-19 Testing. Global Challenges, 5(11), 2100039. https://doi.org/10.1002/gch2.202100039

Valisno JAC, May J, Singh K, Helm EY, Venegas L, Budbazar E, Goodman JB, Nicholson CJ, Avram D, Cohen RA, Mitchell GF, Morgan KG, & Seta F (2021). BCL11B Regulates Arterial Stiffness and Related Target Organ Damage. Circulation Research, 128(6), 755–768. https://doi.org/10.1161/CIRCRESAHA.120.316666

Wang Y, Taylor E, Zikopoulos B, Seta F, Huang N, Hamilton JA, Kantak KM, & Morgan KG (2021). Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects. Neurobiology of Aging, 100, 39–47. https://doi.org/10.1016/j.neurobiolaging.2020.11.017

Zeldich D, Bou Jawde S, Herrmann J, Arnaout L, Griffin M, Grunfeld N, Zhang Y, Krishnan R, Bartolák-Suki E, & Suki B (2021). Stabilizing breathing pattern using local mechanical vibrations: Comparison of deterministic and stochastic stimulations in rodent models of apnea of prematurity. Biomedical Engineering Letters, 11(4), 383–392. https://doi.org/10.1007/s13534-021-00203-x