Clinical Core
The Clinical Core is led by Jesse Mez, MD, MS, and Michael Alosco, Ph.D. The Clinical Core oversees assessments for participants in the HOPE Study. There are approximately 400 participants over age 50 who span the cognitive spectrum (normal cognition, mild cognitive impairment, and dementia). Each year, all participants are interviewed, answer questionnaires, undergo neuropsychological testing and physical exam, and have blood drawn. Additional assessments including brain imaging, lumbar puncture, and engagement with smart technology occur intermittently. Participants are followed for their entire lives and donate their brains to research after death. A major focus of the BU ADRC is understanding how repetitive head impacts from contact sports, military service, and intimate partner violence leads to late life effects, including chronic traumatic encephalopathy (CTE). Approximately 1/3 of the participants have had these types of exposures.
Clinical Data Requests
If you are interested in obtaining data from the BU ADRC Clinical Core, please see the Information for Investigators page.
Core Leaders
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Jesse Mez
Associate Director, BU ADRC
Associate Professor of Neurology
Co-Director, Clinical Research, BU CTE Center
Leader, Clinical Core, BU ADRC
Investigator, BU CTE Center
Co-leader, Framingham Heart Study Brain Aging Program Clinical Core -
Michael Alosco
Director, Boston University Alzheimer’s Disease Research Center Clinical Core
Co-Director, Clinical Research, BU CTE Center
Associate Professor of Neurology, Chobanian & Avedisian SOM