Integrating Racial, Metabolic and Neighborhood Factors Associated with Prostate Cancer Progression and Outcome
Prostate cancer incidence and mortality have consistently been higher in Black men than White men. Recent statistics from U.S. Surveillance, Epidemiology and End Results registry data show that Black men have a 66 percent higher incidence and twice the death rate than white men. This pattern was observed well before... More
Novel Plasma Exosome Biomarkers for Prostate Cancer Progression in Co-Morbid Metabolic Disease
New diagnostic tools to assess risk of metastasis, chemoresistance and relapse in patients with prostate cancer are needed because cancer patient metabolism and metabolic medications are typically not considered clinically in evaluating these risks in prostate cancer. Investigators at Boston Medical Center led by medical oncologist Gretchen Gignac, MD, previously... More
Evaluating New, Improved Methods for Detecting Prostate Cancer
Detection options: MRI-targeted biopsy with ultrasound verses the 12 core approach. More
2021 Shipley Pilot Grant Awards
Congratulations Drs. Jonathan Wisco, Rachel L. Flynn and Alla Grishok! More
New Target to Prevent Castration-resistant Prostate Cancer Metastases
BRD4, a member of the BET bromodomain protein family, could be an important new target to prevent castration-resistant prostate cancer metastases. More
ORIOLE Trial Update
From this Phase 2 trial result, it is reasonable to conclude that Stereotactic ablative radiotherapy (SABR) is a promising treatment approach for men with recurrent hormone-sensitive oligometastatic prostate cancer who wish to delay initiation of androgen deprivation therapy. More
STAMPEDE Trial Update
One of the important and emerging questions in cancer metastasis is: how does the primary prostate tumor engage in cellular and molecular communication with potential locations for a metastasis, distant from the primary tumor, often in skeletal bone. This distant location requires preparation so that the arriving tumor cells can... More
Protein that Promotes Advancement of Prostate Cancer Identified
Researchers at Boston University School of Medicine (BUSM) have discovered that blocking a specific protein, may be a promising strategy to prevent the spread of castration-resistant prostate cancer (CRPC). Under the direction of BUSM’s Gerald V. Denis, PhD, researchers have long studied a family of three closely related proteins, called BET... More
What’s the Impact of Updated Prostate Cancer Genetic Testing Recommendations?
The National Comprehensive Cancer Network (NCCN) issued updated prostate cancer guidelines that include new information about the role of genetic testing for those with prostate cancer1. These updates expand the criteria to include more people with prostate cancer or people with family histories of prostate cancer who may be eligible... More
MRI/Ultrasound Fusion Prostate Biopsy: New Option for Diagnosis
When concern arises that a man may have prostate cancer, the current recommendation is to perform an ultrasound (US) guided biopsy. Using sound waves, we are able to visualize the prostate for sampling of various areas of the gland. However, since we are not able to visualize areas concerning for... More