Affiliate Faculty (Professor – Bioinformatics)
Bimolecular Systems Laboratory
The Bimolecular Systems Laboratory develops and applies computational/mathematical methods, and high throughput experimental methods, to analyze changes in gene and protein expression profiles of cells in response to various endogenous and exogenous signals. In collaboration with the Fraunhofer Center for Manufacturing Innovation, and the Departments of Chemistry and Physics, we are developing and applying new DNA and peptide microarray technologies for fingerprinting the complete molecular state of a cell. Examples include the response to ligands (drugs, toxins, hormones etc), and changes that occur as normal cells mature, differentiate, progress toward disease. The long-range goal is to relate expression patterns to pathways, pathways to networks and networks to function. Our current research is looking into the development and application of experimental and computational methods for high throughput genomic and proteomic analysis. Computational methods for determining protein function and the topology of information processing networks Biological applications range from fundamental (e.g. understanding how specific signals are detected, transduced, amplified, processed and stored) to applied; especially to cancer and immune reactions.